UCL Division of Infection & Immunity
Kartyk Moganeradj: Project Summary
The Role of the Transposable Element IS6110 in the evolution of successful lineages of Mycobacterium tuberculosis.
Dr Catherine Arnold (UCL & HPA),
Dr Ibrahim Abubakar (UCL & HPA),
Dr Pam Sonnenberg (UCL) and
Dr Tim McHugh (UCL)
Mycobacterium tuberculosis molecular typing is based on detecting a range of elements that vary in composition or location. We propose to analyse the evolutionary relationships between two of these elements, insertion sites (IS) and direct repeat (DR) elements together with the historical origins of clinical isolates to establish a map of the divergence of a common Mycobacterium tuberculosis complex (MTBC) ancestor into the closely related species that make up the complex and then ultimately into the few successful so-called ‘modern’ families such as Beijing, Haarlem LAM and T which make up the vast majority of strain types causing disease globally. Using this information an algorithm will be established for the selection and application of molecular typing targets for informed outbreak investigation and surveillance.
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