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Matt's bio & selected papers
Education and Professional Experience
|2010 – present||Royal Society University Research Fellow, UCL|
|2002 - 2010||Wellcome Trust Postdoctoral Research Fellow, UCL|
|2001 – 2002||Tenure-track researcher, Technical University of Delft, The Netherlands|
|1997 - 2001||PhD in Biochemistry and Molecular Genetics, UNSW, Australia|
|1996||Honours [First Class] Molecular Genetics, UNSW, Australia|
|1993 - 1995||Bachelor of Science, University of Adelaide, Australia|
|2012||Wellcome Trust||Wellcome Trust People Awards|
|2012||UCL Crucible Centre||Art/science collaboration|
|2012||AGE UK||Art/science collaboration|
|2012 - 2015||Royal Society||URF research grant|
|2011 - 2016||Royal Society||University Research Fellowship|
|2011 - 2014||BBSRC||New Investigator Award|
|2011 - 2015||UCL Crucible Centre (Medical Research Council)||4y PhD studentship|
Cell Metabolism, 14:154-160
Moderate dietary restriction has been shown to extend lifespan in numerous organisms. Occasionally, contradictory reports arise. Why is this?
This article demonstrates how lifespan responds to nutrient balance and that terms like 'dietary restriction' or 'calorie restriction' are inadequate to explain the phenomenon.
What's more, we show how small changes in the environment or the genetic make up of the organism being studied, can dramatically affect the outcome and interpretation of dietary restriction experiments.
A great deal of research has been performed to uncover the nutrients critical for how dietary restriction might extend lifespan.
Using the fruit fly as a model organism, we show that small changes in the balance of dietary amino acids can fully account for the effects of dietary restriction to extend lifespan and reduce fecundity.
Cell Metabolism, 8:99-104
PLoS Genetics, 3:e57
J Gerontology, 62A:1071-1081
J Biol Chem, 278:3265-3274
J Biol Chem, 277, 37001-37008