A A A

IHA News

Former IHA students start PhD's at Cambridge University

The IHA is pleased to announce that former students Michael Shannack and Nattaphong Rattanavirotkul will both be starting PhD courses at Cambridge University this year. We wish them the best of luck in their studies! More...

Published: Sep 30, 2014 11:57:06 AM

IHA MRes students to receive Distinctions in their degrees!

Congratulations to IHA MRes students Michael Shannack, Nattaphong Rattanavirotkul, Adam Summerfield and Parina Patel. All four received a well-deserved Distinction in their Masters course. We wish them all the best for the future. More...

Published: Sep 19, 2014 3:20:37 PM

Dr Nazif Alic paper published in PLOS Genetics

In their recent paper in PLOS Genetics Alic and co-workers explore the complex relationship between Drosophila foxo, a transcription factor with evolutionarily conserved role in ageing, and Anterior open, an ETS-family transcription factor that is a direct target of dFOXO in the adult gut and whose activation can extend lifespan.

The paper is entitled, "Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster"

View the article here: http://tinyurl.com/off4cqq More...

Published: Sep 19, 2014 9:58:55 AM

Lazaros Foukas


Foukas Lab Website


dr lazaros foukas

Contacts
  • Dr
  • Lazaros
  • Foukas
  • Dr Lazaros Foukas
  • Ex: 51612
  • l.foukas@ucl.ac.uk
  • Website
  • https://iris.ucl.ac.uk/iris/extResource/image/01/LFOUK88
  • 2009-04-01
Address
  • 7815
  • London
Joined UCL
  • 2009-04-01

Research Summary

Ageing is a process of gradual decline in the physiological functions of the organism. Amongst other derangements, ageing is associated with dysfunction in carbohydrate and lipid homeostatic regulatory mechanisms. Consequently, middle-aged and old individuals have a higher risk of suffering from metabolic disorders. The rapidly increasing incidence of obesity and type-2 diabetes necessitates the development of novel therapeutic agents to combat these conditions and their numerous debilitating complications.



Cell signalling pathways have been successfully targeted in the therapy of major diseases, such as cancer and inflammation. Signalling pathways that sense nutrient availability and regulate metabolic responses represent potential points of intervention for treatment of metabolic disorders. Key signalling pathways in metabolic regulation are the PI 3-Kinase (PI3K) and Target of Rapamycin (TOR) pathways.



We aim to study the mechanisms by which growth factor and nutrient sensing signalling pathways regulate metabolism and the impact of their perturbation on health in the context of ageing. We use a combination of mammalian genetics, cell based models and pharmacological approaches to identify components of cell signalling pathways which can be targeted in prevention or therapy of age-related diseases.

Research Activities
  • 853
  • Cell signalling
  • 1335
  • age-related disease
  • 1016
  • ageing
  • 1177
  • cancer
  • 1017
  • metabolic regulation
  • 1497
  • obesity
  • 1498
  • type-2 diabetes

Academic Background

  • Award Year
    Qualification
     
    Institution
  • 2003
    PhD
    Doctor of Philosophy
    University College London
  • 1997
    MS
    Master of Science
    University of Patras
  • 1995
    Dip.
    Diploma
    University of Patras

Biography

Lazaros Foukas obtained a PhD in Biochemistry from University College London. He then
went on to conduct postdoctoral research in Bart Vanhaesebroeck’s lab in the
Ludwig Institute for Cancer Research and then in Barts Cancer Institute, Queen
Mary University of London. He joined the Institute of Healthy Ageing at UCL as
a principal investigator in 2009. His research focuses on the role of
signalling pathways in age related pathologies, such as cancer and metabolic disease.

Collaborators
  • LPART24
  • prof dame linda partridge
  • DGEMS65
  • prof david gems
  • BFKIN15
  • dr brian king
  • MJKIV95
  • prof mika kivimaki
  • DJPEA06
  • dr daniel pearce
  • MKUMA95
  • prof meena kumari
  • MRDUC42
  • prof michael duchen
  • HPIKH73
  • dr hynek pikhart
  • SJDAW90
  • dr sally dawson
  • RCHAR53
  • dr babis rallis

Page last modified on 28 oct 13 16:14