Congratulations to IHA MRes students Michael Shannack, Nattaphong Rattanavirotkul, Adam Summerfield and Parina Patel. All four received a well-deserved Distinction in their Masters course. We wish them all the best for the future. More...
Published: Sep 19, 2014 3:20:37 PM
In their recent paper in PLOS Genetics Alic and co-workers explore the complex relationship between Drosophila foxo, a transcription factor with evolutionarily conserved role in ageing, and Anterior open, an ETS-family transcription factor that is a direct target of dFOXO in the adult gut and whose activation can extend lifespan.
The paper is entitled, "Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster"
View the article here: http://tinyurl.com/off4cqq More...
Published: Sep 19, 2014 9:58:55 AM
Congratulations to Jennifer Tullet (again!)
In September, Dr Jennifer Tullet will cease to be a postdoc, and take up
a Principle Investigator position running her own lab at the University
of Kent, where she will continue her investigations of ageing in C.
elegans. Jennifer also recently spoke at the American Aging Association
meeting in San Antonio, Texas, and recently published a paper entitled
“DAF-16 target identification in C. elegans: past, present and future”
in the journal Biogerontology.
Congratulations to Dr Yila de la Guardia!
Yila de la Guardia recently passed her Ph.D. viva (examiners, Prof Bart
Braeckman from the University of Ghent, and Dr Lazaros Foukas from the
IHA). Yila has now returned to Panama, and she is much missed.
New members of the lab
The lab welcomes three new members! Dr Yuan Zhao moved to the lab from
Cancer Research UK, London, where she worked on telomeres in fission
yeast with Dr Julie Cooper; and Dr Evgeniy Galimov from the National
Research Centre for Preventive Medicine, Moscow, where he worked on ROS
signalling and p66shc with Prof Viktor Skulachev. Both positions are
funded by the Wellcome Trust. Welcome also to Thanet Sornda who recently
started Ph.D. research in the lab. Thanet previously did a Master’s
degree at the Institute of Ageing and Health, Newcastle University, and
is funded by the state of Thailand.
News about David Gems
David gave various talks, e.g. at the Genetics of Aging and Longevity
meeting in Sochi (April), Russia, the British Society for Research on
Ageing meeting in Liverpool (July), and at Oxford and Cambridge
universities. He recently published two essays: 'What is an anti-aging
treatment?' Exp. Gerontol. (2014) 58: 14-18; and 'Evolution of sexually
dimorphic longevity in humans.' Aging (2014) 6: 84-91.
Published: Sep 4, 2014 5:02:16 PM
dr lazaros foukas
Ageing is a process of gradual decline in the physiological functions of the organism. Amongst other derangements, ageing is associated with dysfunction in carbohydrate and lipid homeostatic regulatory mechanisms. Consequently, middle-aged and old individuals have a higher risk of suffering from metabolic disorders. The rapidly increasing incidence of obesity and type-2 diabetes necessitates the development of novel therapeutic agents to combat these conditions and their numerous debilitating complications.
Cell signalling pathways have been successfully targeted in the therapy of major diseases, such as cancer and inflammation. Signalling pathways that sense nutrient availability and regulate metabolic responses represent potential points of intervention for treatment of metabolic disorders. Key signalling pathways in metabolic regulation are the PI 3-Kinase (PI3K) and Target of Rapamycin (TOR) pathways.
We aim to study the mechanisms by which growth factor and nutrient sensing signalling pathways regulate metabolism and the impact of their perturbation on health in the context of ageing. We use a combination of mammalian genetics, cell based models and pharmacological approaches to identify components of cell signalling pathways which can be targeted in prevention or therapy of age-related diseases.
- Cell signalling
- age-related disease
- metabolic regulation
- type-2 diabetes
Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse.
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration
eIF4E binding protein 1 and H-Ras are novel substrates for the protein kinase activity of class-I phosphoinositide 3-kinase.
Direct interaction of major histocompatibility complex class II-derived peptides with class Ia phosphoinositide 3-kinase results in dose-dependent stimulatory effects.
2003PhDDoctor of PhilosophyUniversity College London
1997MSMaster of ScienceUniversity of Patras
1995Dip.DiplomaUniversity of Patras
Lazaros Foukas obtained a PhD in Biochemistry from University College London. He then
went on to conduct postdoctoral research in Bart Vanhaesebroeck’s lab in the
Ludwig Institute for Cancer Research and then in Barts Cancer Institute, Queen
Mary University of London. He joined the Institute of Healthy Ageing at UCL as
a principal investigator in 2009. His research focuses on the role of
signalling pathways in age related pathologies, such as cancer and metabolic disease.
- prof dame linda partridge
- prof david gems
- dr eugene schuster
- dr brian king
- prof mika kivimaki
- dr daniel pearce
- prof meena kumari
- prof michael duchen
- dr hynek pikhart
- dr sally dawson
- dr babis rallis
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