Until recently an EU-funded postdoc in David Gems's lab, Alex Benedetto will shortly set up his own laboratory at the University of Lancaster, in the Department of Biomedical and Life Sciences. There he will continue his investigations of the biology of ageing in model organisms, particularly C. elegans. We wish Alex all the best in setting up his new lab! More...
Published: Jul 20, 2016 2:10:01 PM
New report on the origins of age-related disease in C. elegans More...
Published: Jul 20, 2016 2:04:41 PM
Congratulations to Dr Jorge Ivan Castillo Quan whose paper in Cell Reports was published today. His research, which was carried out during his PhD studies at the Institute of Healthy Ageing, demonstrates that fruit flies live 16% longer than average when given low doses of the mood stabiliser lithium. More...
Published: Apr 7, 2016 5:01:10 PM
dr lazaros foukas
Ageing is a process of gradual decline in the physiological functions of the organism. Amongst other derangements, ageing is associated with dysfunction in carbohydrate and lipid homeostatic regulatory mechanisms. Consequently, middle-aged and old individuals have a higher risk of suffering from metabolic disorders. The rapidly increasing incidence of obesity and type-2 diabetes necessitates the development of novel therapeutic agents to combat these conditions and their numerous debilitating complications.
Cell signalling pathways have been successfully targeted in the therapy of major diseases, such as cancer and inflammation. Signalling pathways that sense nutrient availability and regulate metabolic responses represent potential points of intervention for treatment of metabolic disorders. Key signalling pathways in metabolic regulation are the PI 3-Kinase (PI3K) and Target of Rapamycin (TOR) pathways.
We aim to study the mechanisms by which growth factor and nutrient sensing signalling pathways regulate metabolism and the impact of their perturbation on health in the context of ageing. We use a combination of mammalian genetics, cell based models and pharmacological approaches to identify components of cell signalling pathways which can be targeted in prevention or therapy of age-related diseases.
- Cell signalling
- age-related disease
- metabolic regulation
- type-2 diabetes
Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse.
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration
Direct interaction of major histocompatibility complex class II-derived peptides with class Ia phosphoinositide 3-kinase results in dose-dependent stimulatory effects.
2003PhDDoctor of PhilosophyUniversity College London
1997MSMaster of ScienceUniversity of Patras
1995Dip.DiplomaUniversity of Patras
Lazaros Foukas obtained a PhD in Biochemistry from University College London. He then
went on to conduct postdoctoral research in Bart Vanhaesebroeck’s lab in the
Ludwig Institute for Cancer Research and then in Barts Cancer Institute, Queen
Mary University of London. He joined the Institute of Healthy Ageing at UCL as
a principal investigator in 2009. His research focuses on the role of
signalling pathways in age related pathologies, such as cancer and metabolic disease.
- prof dame linda partridge
- prof david gems
- dr brian king
- prof mika kivimaki
- dr daniel pearce
- prof meena kumari
- prof michael duchen
- dr hynek pikhart
- dr sally dawson
Page last modified on 28 oct 13 16:14