Congratulatsions to Adam Dobson and Nazif Alic whose paper, "Nutritional Programming of Lifespan by FOXO Inhibition on Sugar-Rich Diets," has just been published in Cell Reports. Their study shows that a history of feeding on a high sugar-diet shortens lifespan and changes gene expression. These changes appear to be mediated by FoxO/Daf16 in both flies and worms More...
Published: Jan 11, 2017 10:42:21 AM
The IHA extends a warm welcome to Matías Fuentealba who joins Linda Partridge’s group this week as a PhD student. Matias recently completed his Masters in Biological Sciences at the Universidad de Chile, where his work comprised a “study of the energetics and structural characteristics of NAD and NADP binding sites through statistical potentials.” Welcome to London Matías!
Published: Jan 10, 2017 11:44:35 AM
On Saturday, November 26 2016 BBC Radio 4 broadcast a 1 hr programme entitled "Logan's Run and Intergenerational War", presented by Ed Howker, with extensive contributions from IHA Co-Director Professor David Gems. The programme included in depth discussion of the impact of the ageing of populations, and the prospects for treatments for ageing to improve late-life health. Among other contributors to the programme were former Universities and Science minister David Willetts and the actress Jenny Agutter.
The programme is available for a short period via the BBC iPlayer at http://www.bbc.co.uk/programmes/b083j672#play
Published: Nov 30, 2016 12:53:17 PM
dr lazaros foukas
Ageing is a process of gradual decline in the physiological functions of the organism. Amongst other derangements, ageing is associated with dysfunction in carbohydrate and lipid homeostatic regulatory mechanisms. Consequently, middle-aged and old individuals have a higher risk of suffering from metabolic disorders. The rapidly increasing incidence of obesity and type-2 diabetes necessitates the development of novel therapeutic agents to combat these conditions and their numerous debilitating complications.
Cell signalling pathways have been successfully targeted in the therapy of major diseases, such as cancer and inflammation. Signalling pathways that sense nutrient availability and regulate metabolic responses represent potential points of intervention for treatment of metabolic disorders. Key signalling pathways in metabolic regulation are the PI 3-Kinase (PI3K) and Target of Rapamycin (TOR) pathways.
We aim to study the mechanisms by which growth factor and nutrient sensing signalling pathways regulate metabolism and the impact of their perturbation on health in the context of ageing. We use a combination of mammalian genetics, cell based models and pharmacological approaches to identify components of cell signalling pathways which can be targeted in prevention or therapy of age-related diseases.
- Cell signalling
- age-related disease
- metabolic regulation
- type-2 diabetes
Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse.
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration
eIF4E binding protein 1 and H-Ras are novel substrates for the protein kinase activity of class-I phosphoinositide 3-kinase.
Direct interaction of major histocompatibility complex class II-derived peptides with class Ia phosphoinositide 3-kinase results in dose-dependent stimulatory effects.
2003PhDDoctor of PhilosophyUniversity College London
1997MSMaster of ScienceUniversity of Patras
1995Dip.DiplomaUniversity of Patras
Lazaros Foukas obtained a PhD in Biochemistry from University College London. He then
went on to conduct postdoctoral research in Bart Vanhaesebroeck’s lab in the
Ludwig Institute for Cancer Research and then in Barts Cancer Institute, Queen
Mary University of London. He joined the Institute of Healthy Ageing at UCL as
a principal investigator in 2009. His research focuses on the role of
signalling pathways in age related pathologies, such as cancer and metabolic disease.
- prof dame linda partridge
- prof david gems
- dr brian king
- prof mika kivimaki
- prof meena kumari
- prof michael duchen
- dr hynek pikhart
- dr sally dawson
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