An IHA team led by lab technician Melissa Cabecinha will be running 5km around Regent's Park on Saturday, May 30th as part of CRUK's Race for Life challenge.
If you would like to support our team by making a donation please visit Melissa's fundraising page at: https://www.justgiving.com/iha-ladies
Thank you! More...
Published: May 5, 2015 11:57:57 AM
IHA Director Professor Linda Partridge is one of the organisers of the new Wellcome Trust Conference on Healthy Ageing being held 18-20 May 2015.
Ageing can lead to declining health and function, and it is the major risk factor for cancer, neurodegenerative and cardiovascular disease. This new Wellcome Trust conference will focus on recent discoveries and current challenges in ageing research, with a focus on translating basic research insights into health improvement for older people. We aim to explore the mechanisms of ageing in cells, tissues and organisms in order to identify interventions that can ameliorate its negative effects. The meeting will also emphasise the connection between discoveries made in model organisms and mechanisms leading to healthy ageing in humans.
The meeting is aimed at scientists, clinicians and drug developers involved in research into ageing and other relevant fields. We welcome the submission of abstracts from all areas relevant to the main themes of the meeting. Several oral presentations will be chosen from the abstracts submitted.
Topics will include: Human ageing Stem cells and cellular senescence, Physiology of homeostasis, Nutrition and metabolism, Genome stability, Epigenetics, Systems biology, Drug developmen. More...
Published: Mar 9, 2015 3:44:49 PM
Congratulations to Dr Nazif Alic whose paper has been published in the Royal Society's flagship biological research journal Proceedings B.
Published: Dec 18, 2014 5:19:24 PM
dr lazaros foukas
Ageing is a process of gradual decline in the physiological functions of the organism. Amongst other derangements, ageing is associated with dysfunction in carbohydrate and lipid homeostatic regulatory mechanisms. Consequently, middle-aged and old individuals have a higher risk of suffering from metabolic disorders. The rapidly increasing incidence of obesity and type-2 diabetes necessitates the development of novel therapeutic agents to combat these conditions and their numerous debilitating complications.
Cell signalling pathways have been successfully targeted in the therapy of major diseases, such as cancer and inflammation. Signalling pathways that sense nutrient availability and regulate metabolic responses represent potential points of intervention for treatment of metabolic disorders. Key signalling pathways in metabolic regulation are the PI 3-Kinase (PI3K) and Target of Rapamycin (TOR) pathways.
We aim to study the mechanisms by which growth factor and nutrient sensing signalling pathways regulate metabolism and the impact of their perturbation on health in the context of ageing. We use a combination of mammalian genetics, cell based models and pharmacological approaches to identify components of cell signalling pathways which can be targeted in prevention or therapy of age-related diseases.
- Cell signalling
- age-related disease
- metabolic regulation
- type-2 diabetes
Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse.
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration
eIF4E binding protein 1 and H-Ras are novel substrates for the protein kinase activity of class-I phosphoinositide 3-kinase.
Direct interaction of major histocompatibility complex class II-derived peptides with class Ia phosphoinositide 3-kinase results in dose-dependent stimulatory effects.
2003PhDDoctor of PhilosophyUniversity College London
1997MSMaster of ScienceUniversity of Patras
1995Dip.DiplomaUniversity of Patras
Lazaros Foukas obtained a PhD in Biochemistry from University College London. He then
went on to conduct postdoctoral research in Bart Vanhaesebroeck’s lab in the
Ludwig Institute for Cancer Research and then in Barts Cancer Institute, Queen
Mary University of London. He joined the Institute of Healthy Ageing at UCL as
a principal investigator in 2009. His research focuses on the role of
signalling pathways in age related pathologies, such as cancer and metabolic disease.
- prof dame linda partridge
- prof david gems
- dr brian king
- prof mika kivimaki
- dr daniel pearce
- prof meena kumari
- prof michael duchen
- dr hynek pikhart
- dr sally dawson
- dr babis rallis
Page last modified on 28 oct 13 16:14