Congratulations to the IHA's Dr Jorge Iván Castillo Quan who last week was awarded 1st prize for best poster/presentation at the UCL Faculty of Brain Sciences Symposium. This follows his earlier success at UCL Faculty of Life Sciences Research Day held in September 2013, where he also won 1st prize. Well done Jorge!
Published: Feb 25, 2014 3:24:12 PM
PLOS Genetics paper published today "DAF-16/FoxO Directly Regulates an Atypical AMP- Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in Caenorhabditis elegans"
Congratulations to first author Dr Jennifer M. Tullet and her IHA colleagues whose paper was published in PLOS Genetics today.
Published: Feb 7, 2014 11:49:04 AM
Cell Reports today published an article by several of the IHA's researchers, including first author Dr Nazif Alic. The open-access article can be found here: http://www.cell.com/cell-reports/fulltext/S2211-1247%2814%2900032-1 More...
Published: Feb 7, 2014 11:37:42 AM
dr lazaros foukas
Ageing is a process of gradual decline in the physiological functions of the organism. Amongst other derangements, ageing is associated with dysfunction in carbohydrate and lipid homeostatic regulatory mechanisms. Consequently, middle-aged and old individuals have a higher risk of suffering from metabolic disorders. The rapidly increasing incidence of obesity and type-2 diabetes necessitates the development of novel therapeutic agents to combat these conditions and their numerous debilitating complications.
Cell signalling pathways have been successfully targeted in the therapy of major diseases, such as cancer and inflammation. Signalling pathways that sense nutrient availability and regulate metabolic responses represent potential points of intervention for treatment of metabolic disorders. Key signalling pathways in metabolic regulation are the PI 3-Kinase (PI3K) and Target of Rapamycin (TOR) pathways.
We aim to study the mechanisms by which growth factor and nutrient sensing signalling pathways regulate metabolism and the impact of their perturbation on health in the context of ageing. We use a combination of mammalian genetics, cell based models and pharmacological approaches to identify components of cell signalling pathways which can be targeted in prevention or therapy of age-related diseases.
- Cell signalling
- age-related disease
- metabolic regulation
- type-2 diabetes
Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse.
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration
eIF4E binding protein 1 and H-Ras are novel substrates for the protein kinase activity of class-I phosphoinositide 3-kinase.
2003PhDDoctor of PhilosophyUniversity College London
1997MSMaster of ScienceUniversity of Patras
1995Dip.DiplomaUniversity of Patras
Lazaros Foukas obtained a PhD in Biochemistry from University College London. He then
went on to conduct postdoctoral research in Bart Vanhaesebroeck’s lab in the
Ludwig Institute for Cancer Research and then in Barts Cancer Institute, Queen
Mary University of London. He joined the Institute of Healthy Ageing at UCL as
a principal investigator in 2009. His research focuses on the role of
signalling pathways in age related pathologies, such as cancer and metabolic disease.
- prof linda partridge
- prof david gems
- dr eugene schuster
- dr brian king
- prof mika kivimaki
- dr daniel pearce
- dr meena kumari
- prof michael duchen
- dr hynek pikhart
- dr sally dawson
- dr babis rallis
Page last modified on 28 oct 13 16:14