The death fluorescence study provoked some interest from the news media,
both nationally and internationally. At home, it was covered by New
Scientist (online), and small items appeared in the Daily Mail, and
Metro (London). There was more interest in the USA, where David Gems was
interviewed for the National Public Radio programme “All Things
Considered” (similar to the Today programme on R4), and the story was
covered by Scientific American (online) and The Scientist. More widely,
the story was covered by news media in France, Canada (in the
publication "Vice"), Sweden, Romania (where there was a colourful TV
news item), Ghana, China and Indonesia. More...
Published: Sep 9, 2013 4:22:23 PM
Sunday Times Magazine, August 25th 2013.
Published: Aug 27, 2013 12:18:45 PM
We are pleased to announce that the Epigenetics journal have accepted Daniel Pearce, Stephan Beck and Tosin Taiwo's paper for publication. The article's title is "DNA methylation analysis of murine haematopoietic side population cells during ageing." For more information please contact Dr Pearce.
Published: Aug 6, 2013 11:02:17 AM
dr lazaros foukas
Ageing is a process of gradual decline in the physiological functions of the organism. Amongst other derangements, ageing is associated with dysfunction in carbohydrate and lipid homeostatic regulatory mechanisms. Consequently, middle-aged and old individuals have a higher risk of suffering from metabolic disorders. The rapidly increasing incidence of obesity and type-2 diabetes necessitates the development of novel therapeutic agents to combat these conditions and their numerous debilitating complications.
Cell signalling pathways have been successfully targeted in the therapy of major diseases, such as cancer and inflammation. Signalling pathways that sense nutrient availability and regulate metabolic responses represent potential points of intervention for treatment of metabolic disorders. Key signalling pathways in metabolic regulation are the PI 3-Kinase (PI3K) and Target of Rapamycin (TOR) pathways.
We aim to study the mechanisms by which growth factor and nutrient sensing signalling pathways regulate metabolism and the impact of their perturbation on health in the context of ageing. We use a combination of mammalian genetics, cell based models and pharmacological approaches to identify components of cell signalling pathways which can be targeted in prevention or therapy of age-related diseases.
- Cell signalling
- age-related disease
- metabolic regulation
- type-2 diabetes
Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse.
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration
eIF4E binding protein 1 and H-Ras are novel substrates for the protein kinase activity of class-I phosphoinositide 3-kinase.
Direct interaction of major histocompatibility complex class II-derived peptides with class Ia phosphoinositide 3-kinase results in dose-dependent stimulatory effects.
2003PhDDoctor of PhilosophyUniversity College London
1997MSMaster of ScienceUniversity of Patras
1995Dip.DiplomaUniversity of Patras
Lazaros Foukas obtained a PhD in Biochemistry from University College London. He then
went on to conduct postdoctoral research in Bart Vanhaesebroeck’s lab in the
Ludwig Institute for Cancer Research and then in Barts Cancer Institute, Queen
Mary University of London. He joined the Institute of Healthy Ageing at UCL as
a principal investigator in 2009. His research focuses on the role of
signalling pathways in age related pathologies, such as cancer and metabolic disease.
- dr emmanouil stamatakis
- prof linda partridge
- prof david gems
- dr eugene schuster
- dr brian king
- prof mika kivimaki
- dr daniel pearce
- dr meena kumari
- prof michael duchen
- dr hynek pikhart
- dr sally dawson
- dr babis rallis
Page last modified on 28 oct 13 16:14