Congratulations and many thanks to Caroline Araiz and Melissa Cabecinha who recently competed in CRUK's 10k Race for Life in London. Not only did they exceed their £300 fundraising target but Caroline was the first runner to cross the line with an amazing time of 44m 21s and Melissa ran her first ever 10k!
Published: Jul 8, 2014 4:42:56 PM
Congratulations to the IHA's Sahar Emran who recently had a paper published in the journal Aging. Her paper shows how the drug rapamycin can overcome the lifespan shortening effects of eating a diet high in amino acids. The article can be viewed here.
Published: May 29, 2014 4:20:34 PM
The IHA's David Gems will feature in the upcoming episode of ‘Bang Goes the Theory’ which airs on Monday 31st March at 7.30pm on BBC1 and iPlayer. The episode focuses on ageing. http://www.bbc.co.uk/programmes/b00lwxj1 More...
Published: Mar 27, 2014 4:38:10 PM
dr lazaros foukas
Ageing is a process of gradual decline in the physiological functions of the organism. Amongst other derangements, ageing is associated with dysfunction in carbohydrate and lipid homeostatic regulatory mechanisms. Consequently, middle-aged and old individuals have a higher risk of suffering from metabolic disorders. The rapidly increasing incidence of obesity and type-2 diabetes necessitates the development of novel therapeutic agents to combat these conditions and their numerous debilitating complications.
Cell signalling pathways have been successfully targeted in the therapy of major diseases, such as cancer and inflammation. Signalling pathways that sense nutrient availability and regulate metabolic responses represent potential points of intervention for treatment of metabolic disorders. Key signalling pathways in metabolic regulation are the PI 3-Kinase (PI3K) and Target of Rapamycin (TOR) pathways.
We aim to study the mechanisms by which growth factor and nutrient sensing signalling pathways regulate metabolism and the impact of their perturbation on health in the context of ageing. We use a combination of mammalian genetics, cell based models and pharmacological approaches to identify components of cell signalling pathways which can be targeted in prevention or therapy of age-related diseases.
- Cell signalling
- age-related disease
- metabolic regulation
- type-2 diabetes
Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse.
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration
Direct interaction of major histocompatibility complex class II-derived peptides with class Ia phosphoinositide 3-kinase results in dose-dependent stimulatory effects.
2003PhDDoctor of PhilosophyUniversity College London
1997MSMaster of ScienceUniversity of Patras
1995Dip.DiplomaUniversity of Patras
Lazaros Foukas obtained a PhD in Biochemistry from University College London. He then
went on to conduct postdoctoral research in Bart Vanhaesebroeck’s lab in the
Ludwig Institute for Cancer Research and then in Barts Cancer Institute, Queen
Mary University of London. He joined the Institute of Healthy Ageing at UCL as
a principal investigator in 2009. His research focuses on the role of
signalling pathways in age related pathologies, such as cancer and metabolic disease.
- prof dame linda partridge
- prof david gems
- dr eugene schuster
- dr brian king
- prof mika kivimaki
- dr daniel pearce
- dr meena kumari
- prof michael duchen
- dr hynek pikhart
- dr sally dawson
- dr babis rallis
Page last modified on 28 oct 13 16:14