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IHA News

IHA Race for Life teams kicks off with Bake Sale

The ladies of the IHA who this year will be participating in Cancer Research UK's 'Race for Life' successfully held a bake sale on Wednesday and raised an impressive £290 towards their total goal! A huge variety of delicious cakes, generously baked by the team and their friends from the IHA, were snapped up by hungry staff and students alike. Thanks team and well done! If you would like to make a donation to this worthy cause please visit the team's JustGiving page at: http://www.raceforlifesponsorme.org More...

Published: May 10, 2013 10:26:26 AM

Giovanna Vinti awarded UCL Green Impact Award

We are delighted to announce that the 'Green-Darwin' Green Impact Team has won two Bronze Awards which were presented by the Provost at an Awards Ceremony held last week. The IHA's Giovanna Vinti secured the first award for 'Green-Darwin Labs' and the 'Green Darwin' team won a second.

These fantastic achievements form part of the efforts of the wider UCL community in pressing forward the green agenda. Awards went to teams across UCL for work that included putting up awareness-raising notices and posters encouraging people to switch off lights and equipment when not needed, potentially saving 7,038kg CO2 per year; and likewise to print and photocopy double-sided, potentially saving 108,594kg CO2 and £40,220 on resource costs this year across the institution. More...

Published: Apr 30, 2013 10:37:33 AM

Carolina Soto Palma to attend The Times Cheltenham Science Festival

Congratulations to Carolina Soto Palma, an MRes student under the supervision of Dr. Gene Schuster, who has been awarded one of only ten UCL Graduate School bursaries to attend The Times Cheltenham Science Festival. More...

Published: Apr 24, 2013 3:37:38 PM


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Gene Schuster

dr eugene schuster

Profile Image
Contacts
  • Dr
  • Eugene
  • Francis
  • Schuster
  • Dr Eugene Schuster
  • Tel: 020 7679 2468
  • Fax: 020 7679 7096
  • e.schuster@ucl.ac.uk
  • https://iris.ucl.ac.uk/iris/extResource/image/01/ESCHU11
  • 2009-02-25
Address
  • 3152
  • 118B
  • Darwin Building
  • Gower Street
  • London
  • WC1E 6BT
Appointment
  • RESSRF
  • 2009-02-25
  • 1
  • Senior Research Fellow
  • GEE
  • Genetics, Evolution & Environment
  • F1
  • Div of Biosciences
Joined UCL
  • 2009-02-25

Research Summary

Recent ageing studies have revealed a very surprising finding:  Ageing can be regulated.  Even more surprising is that many of the classic signaling pathways that have been exhaustively studied for many years are involved in the regulation of ageing.  Down regulation of the insulin/IGF-1 signaling (IIS) pathway can result in long-lived worms, flies, mice and possibly humans.  Mutations in insulin/insulin-like ligand receptors disrupt a downstream phosphorylation cascade resulting in the nuclear localization of a foxO forhead transcription factor, gene expression changes in hundreds to thousands of genes and long –lived animals.  Our main focus is to understand the mechanisms of foxO gene regulation in long-lived worms and to determine the extent of conversation of these mechanism across a wide range of species.
Research Activities
  • 853
  • Cell signalling
  • 3224
  • Regulation of Ageing
1 - 10 of 23 Publications Page: 1 of 2 Next »

Metformin retards aging in C.elegans by altering microbial folate and methionine metabolism
Journal article
Ref Type: Journal article

Sex peptide of Drosophila melanogaster males is a global regulator of reproductive processes in females
Journal article
Ref Type: Journal article

Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling
Journal article
Ref Type: Journal article
Publisher: EMBO and Macmillan Publishers Limited

DamID in C-elegans reveals longevity-associated targets of DAF-16/FoxO
Journal article
Ref Type: Journal article
Publisher: NATURE PUBLISHING GROUP

DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO
Journal article
Ref Type: Journal article

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Journal article
Ref Type: Journal article

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
Journal article
Ref Type: Journal article

Correcting for sequence biases in present/absent calls
Journal article
Ref Type: Journal article
Publisher: BIOMED CENTRAL LTD

Evolutionarily conservation of regulated longevity assurance mechanisms
Journal article
Ref Type: Journal article

Estimation and correction of non-specific binding in a large-scale spike-in experiment
Journal article
Ref Type: Journal article
Publisher: BIOMED CENTRAL LTD

Academic Background

  • Award Year
    Qualification
     
    Institution
  • 2004
    PhD
    Doctor of Philosophy
    King's College London
  • 1994
    BSc
    Bachelor of Science
    Massachusetts Institute of Technology

Biography

Dr. Eugene Schuster is a MRC Career Development Fellow at UCL in the Institute of Healthy Ageing and G.E.E. Dept.  After a BSc at MIT, he started a PhD at KCL studying DNA methylation relating to Fragile-X Syndrome.  He then spent five years working at the European Bioinformatics Institute as part of the Functional Genomics of Ageing Consortium, working on conserved genes/pathways that regulate lifespan in worms, flies and mice.  He is currently heading a multi-disciplinary team (experimental and computational) that is attempting to develop high-throughput techniques to better understand how certain transcription factors regulate lifespan and influence RNA expression.

Additional Information
  • Bioinformatics
  • C. elegans
  • Functional Genomics
  • Gene Regulation
  • Transcriptome
Collaborators
  • LPART24
  • prof linda partridge
  • DGEMS65
  • prof david gems
  • DJPEA06
  • dr daniel pearce
  • MRDUC42
  • prof michael duchen
  • RCHAR53
  • dr babis rallis
  • LFOUK88
  • dr lazaros foukas

Page last modified on 09 aug 11 11:19