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IHA News

Former IHA students start PhD's at Cambridge University

The IHA is pleased to announce that former students Michael Shannack and Nattaphong Rattanavirotkul will both be starting PhD courses at Cambridge University this year. We wish them the best of luck in their studies! More...

Published: Sep 30, 2014 11:57:06 AM

IHA MRes students to receive Distinctions in their degrees!

Congratulations to IHA MRes students Michael Shannack, Nattaphong Rattanavirotkul, Adam Summerfield and Parina Patel. All four received a well-deserved Distinction in their Masters course. We wish them all the best for the future. More...

Published: Sep 19, 2014 3:20:37 PM

Dr Nazif Alic paper published in PLOS Genetics

In their recent paper in PLOS Genetics Alic and co-workers explore the complex relationship between Drosophila foxo, a transcription factor with evolutionarily conserved role in ageing, and Anterior open, an ETS-family transcription factor that is a direct target of dFOXO in the adult gut and whose activation can extend lifespan.

The paper is entitled, "Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster"

View the article here: http://tinyurl.com/off4cqq More...

Published: Sep 19, 2014 9:58:55 AM


dr eugene schuster

Profile Image
Contacts
  • Dr
  • Eugene
  • Francis
  • Schuster
  • Dr Eugene Schuster
  • Tel: 020 7679 2468
  • Ex: 32468
  • Fax: 020 7679 7096
  • e.schuster@ucl.ac.uk
  • https://iris.ucl.ac.uk/iris/extResource/image/01/ESCHU11
  • 2009-02-25
Address
  • 3152
  • 118B
  • Darwin Building
  • Gower Street
  • London
  • WC1E 6BT
Joined UCL
  • 2009-02-25

Research Summary

Recent ageing studies have revealed a very surprising finding:  Ageing can be regulated.  Even more surprising is that many of the classic signaling pathways that have been exhaustively studied for many years are involved in the regulation of ageing.  Down regulation of the insulin/IGF-1 signaling (IIS) pathway can result in long-lived worms, flies, mice and possibly humans.  Mutations in insulin/insulin-like ligand receptors disrupt a downstream phosphorylation cascade resulting in the nuclear localization of a foxO forhead transcription factor, gene expression changes in hundreds to thousands of genes and long –lived animals.  Our main focus is to understand the mechanisms of foxO gene regulation in long-lived worms and to determine the extent of conversation of these mechanism across a wide range of species.
Research Activities
  • 853
  • Cell signalling
  • 3224
  • Regulation of Ageing
1 - 10 of 28 Publications Page: 1 of 3 Next »

Ref Type: Journal article
Publisher: EMBO and Macmillan Publishers Limited

Ref Type: Journal article
Publisher: NATURE PUBLISHING GROUP

Academic Background

  • Award Year
    Qualification
     
    Institution
  • 2004
    PhD
    Doctor of Philosophy
    King's College London
  • 1994
    BSc
    Bachelor of Science
    Massachusetts Institute of Technology

Biography

Dr. Eugene Schuster is a MRC Career Development Fellow at UCL in the Institute of Healthy Ageing and G.E.E. Dept.  After a BSc at MIT, he started a PhD at KCL studying DNA methylation relating to Fragile-X Syndrome.  He then spent five years working at the European Bioinformatics Institute as part of the Functional Genomics of Ageing Consortium, working on conserved genes/pathways that regulate lifespan in worms, flies and mice.  He is currently heading a multi-disciplinary team (experimental and computational) that is attempting to develop high-throughput techniques to better understand how certain transcription factors regulate lifespan and influence RNA expression.

Additional Information
  • Bioinformatics
  • C. elegans
  • Functional Genomics
  • Gene Regulation
  • Transcriptome
Collaborators
  • LPART24
  • prof dame linda partridge
  • DGEMS65
  • prof david gems
  • DJPEA06
  • dr daniel pearce
  • MRDUC42
  • prof michael duchen
  • RCHAR53
  • dr babis rallis
  • LFOUK88
  • dr lazaros foukas

Page last modified on 03 jul 13 14:22