A A A

IHA News

Science Paper published

A recent Science article published by a team of UCL researchers including the IHA's Dr Teresa Niccoli sheds light into toxicity mechanisms. View the article here: http://goo.gl/2sgNCb More...

Published: Aug 19, 2014 10:24:04 AM

Knudra Transgenics prize success for IHA

In a recent competition organised by the biotech company KNUDRA TRANSGENICS three members of the IHA were awarded prizes to make custom transgenic animals.

Second prize $3000 to Nuria Vergara to develop the project "Can human FOXO3a replace DAF-16 to promote longevity in C. elegans?" using CRSPR technology.

Third prize £1500 to Jennifer Tullet to investigate "How do translational errors affect longevity and health in C. elegans?"

Sixth prize $500 to Lamia Mestek to expand our knowledge in "Understanding the role of DAF-16 transcription factor in longevity"

The results of the competition can be checked in the following link: http://knudragrants.knudra.com/?page_id=39

Congratulations to all the winners!!!
More...

Published: Aug 19, 2014 10:10:57 AM

New Wellcome Trust video 'Until' features IHA scientists

The Wellcome Trust’s online publication, Mosaic, have released a new video ‘Until’, an exploration of ageing which asks the question, ‘how long would you like to live?’. The video includes interviews with leading ageing scientists (including the IHA's David Gems and Linda Partridge), transhumanists, elderly people and the young children and asks them when they think would be an appropriate time to die, if they had the choice. It also explores the possibilities and realities of extended lifespans in the future. The video can be found here: http://youtu.be/BsUZHyh4n-c More...

Published: Aug 6, 2014 11:44:15 AM


dr eugene schuster

Profile Image
Contacts
  • Dr
  • Eugene
  • Francis
  • Schuster
  • Dr Eugene Schuster
  • Tel: 020 7679 2468
  • Ex: 32468
  • Fax: 020 7679 7096
  • e.schuster@ucl.ac.uk
  • https://iris.ucl.ac.uk/iris/extResource/image/01/ESCHU11
  • 2009-02-25
Address
  • 3152
  • 118B
  • Darwin Building
  • Gower Street
  • London
  • WC1E 6BT
Joined UCL
  • 2009-02-25

Research Summary

Recent ageing studies have revealed a very surprising finding:  Ageing can be regulated.  Even more surprising is that many of the classic signaling pathways that have been exhaustively studied for many years are involved in the regulation of ageing.  Down regulation of the insulin/IGF-1 signaling (IIS) pathway can result in long-lived worms, flies, mice and possibly humans.  Mutations in insulin/insulin-like ligand receptors disrupt a downstream phosphorylation cascade resulting in the nuclear localization of a foxO forhead transcription factor, gene expression changes in hundreds to thousands of genes and long –lived animals.  Our main focus is to understand the mechanisms of foxO gene regulation in long-lived worms and to determine the extent of conversation of these mechanism across a wide range of species.
Research Activities
  • 853
  • Cell signalling
  • 3224
  • Regulation of Ageing
1 - 10 of 27 Publications Page: 1 of 3 Next »

Ref Type: Journal article
Publisher: EMBO and Macmillan Publishers Limited

Ref Type: Journal article
Publisher: NATURE PUBLISHING GROUP

Academic Background

  • Award Year
    Qualification
     
    Institution
  • 2004
    PhD
    Doctor of Philosophy
    King's College London
  • 1994
    BSc
    Bachelor of Science
    Massachusetts Institute of Technology

Biography

Dr. Eugene Schuster is a MRC Career Development Fellow at UCL in the Institute of Healthy Ageing and G.E.E. Dept.  After a BSc at MIT, he started a PhD at KCL studying DNA methylation relating to Fragile-X Syndrome.  He then spent five years working at the European Bioinformatics Institute as part of the Functional Genomics of Ageing Consortium, working on conserved genes/pathways that regulate lifespan in worms, flies and mice.  He is currently heading a multi-disciplinary team (experimental and computational) that is attempting to develop high-throughput techniques to better understand how certain transcription factors regulate lifespan and influence RNA expression.

Additional Information
  • Bioinformatics
  • C. elegans
  • Functional Genomics
  • Gene Regulation
  • Transcriptome
Collaborators
  • LPART24
  • prof dame linda partridge
  • DGEMS65
  • prof david gems
  • DJPEA06
  • dr daniel pearce
  • MRDUC42
  • prof michael duchen
  • RCHAR53
  • dr babis rallis
  • LFOUK88
  • dr lazaros foukas

Page last modified on 03 jul 13 14:22