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IHA News

Race for Life!

Congratulations and many thanks to Caroline Araiz and Melissa Cabecinha who recently competed in CRUK's 10k Race for Life in London. Not only did they exceed their £300 fundraising target but Caroline was the first runner to cross the line with an amazing time of 44m 21s and Melissa ran her first ever 10k!
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Published: Jul 8, 2014 4:42:56 PM

Sahar Emran has paper published in Aging

Congratulations to the IHA's Sahar Emran who recently had a paper published in the journal Aging. Her paper shows how the drug rapamycin can overcome the lifespan shortening effects of eating a diet high in amino acids. The article can be viewed here.

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Published: May 29, 2014 4:20:34 PM

Prof David Gems on BBC1's 'Bang Goes The Theory' 31/03/2014

The IHA's David Gems will feature in the upcoming episode of  ‘Bang Goes the Theory’ which airs on Monday 31st March at 7.30pm on BBC1 and iPlayer. The episode focuses on ageing. http://www.bbc.co.uk/programmes/b00lwxj1 More...

Published: Mar 27, 2014 4:38:10 PM


dr eugene schuster

Profile Image
Contacts
  • Dr
  • Eugene
  • Francis
  • Schuster
  • Dr Eugene Schuster
  • Tel: 020 7679 2468
  • Ex: 32468
  • Fax: 020 7679 7096
  • e.schuster@ucl.ac.uk
  • https://iris.ucl.ac.uk/iris/extResource/image/01/ESCHU11
  • 2009-02-25
Address
  • 3152
  • 118B
  • Darwin Building
  • Gower Street
  • London
  • WC1E 6BT
Joined UCL
  • 2009-02-25

Research Summary

Recent ageing studies have revealed a very surprising finding:  Ageing can be regulated.  Even more surprising is that many of the classic signaling pathways that have been exhaustively studied for many years are involved in the regulation of ageing.  Down regulation of the insulin/IGF-1 signaling (IIS) pathway can result in long-lived worms, flies, mice and possibly humans.  Mutations in insulin/insulin-like ligand receptors disrupt a downstream phosphorylation cascade resulting in the nuclear localization of a foxO forhead transcription factor, gene expression changes in hundreds to thousands of genes and long –lived animals.  Our main focus is to understand the mechanisms of foxO gene regulation in long-lived worms and to determine the extent of conversation of these mechanism across a wide range of species.
Research Activities
  • 853
  • Cell signalling
  • 3224
  • Regulation of Ageing
1 - 10 of 27 Publications Page: 1 of 3 Next »

Ref Type: Journal article
Publisher: EMBO and Macmillan Publishers Limited

Ref Type: Journal article
Publisher: NATURE PUBLISHING GROUP

Academic Background

  • Award Year
    Qualification
     
    Institution
  • 2004
    PhD
    Doctor of Philosophy
    King's College London
  • 1994
    BSc
    Bachelor of Science
    Massachusetts Institute of Technology

Biography

Dr. Eugene Schuster is a MRC Career Development Fellow at UCL in the Institute of Healthy Ageing and G.E.E. Dept.  After a BSc at MIT, he started a PhD at KCL studying DNA methylation relating to Fragile-X Syndrome.  He then spent five years working at the European Bioinformatics Institute as part of the Functional Genomics of Ageing Consortium, working on conserved genes/pathways that regulate lifespan in worms, flies and mice.  He is currently heading a multi-disciplinary team (experimental and computational) that is attempting to develop high-throughput techniques to better understand how certain transcription factors regulate lifespan and influence RNA expression.

Additional Information
  • Bioinformatics
  • C. elegans
  • Functional Genomics
  • Gene Regulation
  • Transcriptome
Collaborators
  • LPART24
  • prof dame linda partridge
  • DGEMS65
  • prof david gems
  • DJPEA06
  • dr daniel pearce
  • MRDUC42
  • prof michael duchen
  • RCHAR53
  • dr babis rallis
  • LFOUK88
  • dr lazaros foukas

Page last modified on 03 jul 13 14:22