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IHA News

Prof David Gems on BBC1's 'Bang Goes The Theory' 31/03/2014

The IHA's David Gems will feature in the upcoming episode of  ‘Bang Goes the Theory’ which airs on Monday 31st March at 7.30pm on BBC1 and iPlayer. The episode focuses on ageing. http://www.bbc.co.uk/programmes/b00lwxj1 More...

Published: Mar 27, 2014 4:38:10 PM

4 year PhD studentship in the IHA available

A 4 year PhD studentship to study under the supervision of Dr Nazif Alic is now available. The project will examine how genetically or pharmacologically induced changes to gene expression, at the level of transcriptional regulation, extend healthy lifespan in Drosophila melanogaster. To explore this question the student will use a broad range of techniques, including fly genetics and physiology, molecular biology, microscopy, protein chemistry and genomics. The student will gain a broad training in basic biogerontology that will prove relevant to a career in any of the currently relevant aspects of ageing and ageing related-disease. More...

Published: Mar 25, 2014 10:08:50 AM

Dr Jorge Iván Castillo Quan receives Faculty Prize

Congratulations to the IHA's Dr Jorge Iván Castillo Quan who last week was awarded 1st prize for best poster/presentation at the UCL Faculty of Brain Sciences Symposium. This follows his earlier success at UCL Faculty of Life Sciences Research Day held in September 2013, where he also won 1st prize. Well done Jorge!
More...

Published: Feb 25, 2014 3:24:12 PM


dr eugene schuster

Profile Image
Contacts
  • Dr
  • Eugene
  • Francis
  • Schuster
  • Dr Eugene Schuster
  • Tel: 020 7679 2468
  • Ex: 32468
  • Fax: 020 7679 7096
  • e.schuster@ucl.ac.uk
  • https://iris.ucl.ac.uk/iris/extResource/image/01/ESCHU11
  • 2009-02-25
Address
  • 3152
  • 118B
  • Darwin Building
  • Gower Street
  • London
  • WC1E 6BT
Joined UCL
  • 2009-02-25

Research Summary

Recent ageing studies have revealed a very surprising finding:  Ageing can be regulated.  Even more surprising is that many of the classic signaling pathways that have been exhaustively studied for many years are involved in the regulation of ageing.  Down regulation of the insulin/IGF-1 signaling (IIS) pathway can result in long-lived worms, flies, mice and possibly humans.  Mutations in insulin/insulin-like ligand receptors disrupt a downstream phosphorylation cascade resulting in the nuclear localization of a foxO forhead transcription factor, gene expression changes in hundreds to thousands of genes and long –lived animals.  Our main focus is to understand the mechanisms of foxO gene regulation in long-lived worms and to determine the extent of conversation of these mechanism across a wide range of species.
Research Activities
  • 853
  • Cell signalling
  • 3224
  • Regulation of Ageing
1 - 10 of 27 Publications Page: 1 of 3 Next »

Ref Type: Journal article
Publisher: EMBO and Macmillan Publishers Limited

Ref Type: Journal article
Publisher: NATURE PUBLISHING GROUP

Academic Background

  • Award Year
    Qualification
     
    Institution
  • 2004
    PhD
    Doctor of Philosophy
    King's College London
  • 1994
    BSc
    Bachelor of Science
    Massachusetts Institute of Technology

Biography

Dr. Eugene Schuster is a MRC Career Development Fellow at UCL in the Institute of Healthy Ageing and G.E.E. Dept.  After a BSc at MIT, he started a PhD at KCL studying DNA methylation relating to Fragile-X Syndrome.  He then spent five years working at the European Bioinformatics Institute as part of the Functional Genomics of Ageing Consortium, working on conserved genes/pathways that regulate lifespan in worms, flies and mice.  He is currently heading a multi-disciplinary team (experimental and computational) that is attempting to develop high-throughput techniques to better understand how certain transcription factors regulate lifespan and influence RNA expression.

Additional Information
  • Bioinformatics
  • C. elegans
  • Functional Genomics
  • Gene Regulation
  • Transcriptome
Collaborators
  • DGEMS65
  • prof david gems
  • DJPEA06
  • dr daniel pearce
  • MRDUC42
  • prof michael duchen
  • RCHAR53
  • dr babis rallis
  • LFOUK88
  • dr lazaros foukas

Page last modified on 03 jul 13 14:22