Congratulations to Dr Teresa Niccoli whose paper "Increased Glucose Transport into Neurons Rescues Ab Toxicity in Drosophila" has just been published in Current Biology by Cell Press. More...
Published: Aug 17, 2016 3:05:35 PM
The Institute of Healthy Ageing is currently seeking a post-doctoral research associate to work on the following ARUK-funded project.
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating, mid-life, neurodegenerative disorders for which no cure is currently available. Large expansions of a hexanucleotide GGGGCC-repeat in the first intron of the C9orf72 gene is the most common genetic cause of both ALS and FTD. We recently developed novel Drosophila models of C9orf72 repeat-induced neurodegeneration (Mizielinska et al Science 2014, 345:1192-1194).
This 3-year post-doctoral position will build on this work by investigating disease mechanisms in a range of C9orf72 fly lines using several approaches including genome-wide transcriptomic and translational analyses in both flies and iPSC-neurons. You will work as part of a collaborative team of investigators in the excellent and supportive scientific research community of UCL.
The post is funded for 3 years in the first instance by Alzheimer’s Research UK and is available from October 2016.
For full information and to apply please visit the UCL website at https://goo.gl/E5vk8j
Published: Aug 11, 2016 2:27:25 PM
Until recently an EU-funded postdoc in David Gems's lab, Alex Benedetto will shortly set up his own laboratory at the University of Lancaster, in the Department of Biomedical and Life Sciences. There he will continue his investigations of the biology of ageing in model organisms, particularly C. elegans. We wish Alex all the best in setting up his new lab! More...
Published: Jul 20, 2016 2:10:01 PM
dr daniel pearce
- Room 325 Darwin Building
- Gower Street
- WC1E 6BT
- Genetics, Evolution & Environment
- Div of Biosciences
Stem cells have been found in most tissues/organs. These stem cells usually produce replacements for lost and damaged cells, and it is not completely understood how this regenerative capacity becomes diminished during ageing.
- Analysis of the role of stem cell-specific anti-toxicity mechanisms during ageing
- Long-term tracking of the dynamics of age-based alterations in stem and progenitor cells
- Analysis of the effect of calorific restriction on murine haematopoietic stem ageing.
of stem cell epigenetic alterations during ageing and how this alters gene
- Cell signalling
- The biology of ageing and the role of somatic stem cells in this process.
Development of a quantitative real-time polymerase chain reaction method for monitoring CEBPA mutations in normal karyotype acute myeloid leukaemia.
AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML
Out of the blue: a comparison of Hoechst side population (SP) analysis of murine bone marrow using 325, 363 and 407 nm excitation sources.
Characterization of cells with a high aldehyde dehydrogenase activity from cord blood and acute myeloid leukemia samples
Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia.
- ABC transporter
- Ageing of haematopoietic stem cells
- Asymmetric cell division
- Cancer progression
- DNA damage
- DNA repair
- Human cell culture
- Oxidative stress
- Stem cells
- prof dame linda partridge
- prof david gems
- prof michael duchen
- prof david marsh
- dr lazaros foukas
Page last modified on 03 jul 13 14:22