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IHA News

Dr Nazif Alic paper published in Royal Society Proceedings B

Congratulations to Dr Nazif Alic whose paper has been published in the Royal Society's flagship biological research journal Proceedings B.
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Published: Dec 18, 2014 5:19:24 PM

Linda Partridge to speak at Nobel Week Dialogue, Live streaming and Q&A

Join in the digital discussion on ageing with IHA Director Linda Partridge as part of this year's Nobel Week Dialogue on 9th December.  More...

Published: Dec 4, 2014 11:04:44 AM

IHA Director Prof Linda Partridge honoured with BBSRC Excellence Award

IHA Director, Professor Linda Partridge, has been recognised with a BBSRC Anniversary Award for Excellence in Bioscience.

The Biotechnology and Biological Sciences Research Council (BBSRC) has recognised outstanding contributions to bioscience made by four of its research community. As part of BBSRC’s 20th anniversary, the awards demonstrate pride for the UK's world-leading bioscience research base and the impact it has achieved in the last two decades.

The awards will be presented at the Great British Bioscience Festival in November.

Professor Jackie Hunter, BBSRC Chief Executive, said: "Our 20th anniversary year is the perfect time to acknowledge and celebrate the achievements of researchers that BBSRC has supported. These awards highlight outstanding achievements that benefit us all and help to make the UK world-leading in bioscience."

Congratulations Linda!
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Published: Nov 7, 2014 4:31:19 PM


dr daniel pearce

Contacts
  • Dr
  • Daniel
  • John
  • Pearce
  • Dr Daniel Pearce
  • Tel: 020 76794393
  • Ex: 34393
  • daniel.pearce@ucl.ac.uk
  • Website
  • https://iris.ucl.ac.uk/iris/extResource/image/01/DJPEA06
  • 2007-09-28
Address
  • 1019
  • Room 325 Darwin Building
  • Gower Street
  • London
  • WC1E 6BT
Joined UCL
  • 2007-09-28

Research Summary

Stem cells have been found in most tissues/organs. These stem cells produce replacements for lost and damaged cells, and it is not completely understood how this regenerative capacity becomes diminished during ageing. One hypothesis is that stem cells are more likely to sacrifice themselves than risk potentially cancer-causing damage being passed onto progeny. This should reduce the incidence of cancer, but ultimately, may lead to a reduction in stem cells with age that contributes to the ageing process.

Current research aims include;

  • Characterisation of age-based alterations in the phenotype and function of murine and human haematopoietic stem cells,
  • Analysis of the role of haematopoietic stem cell-specific antitoxicity mechanisms during ageing
  • Long-term tracking of the dynamics of age-based alterations in stem and progenitor cells
  • Analysis of stem cell epigenetic alterations during ageing and how this alters gene expression
  • Analysis of the effect of calorific restriction on murine haematopoietic stem ageing.


Research Activities
  • 853
  • Cell signalling
  • 766
  • The biology of ageing and the role of somatic stem cells in this process.

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Additional Information
  • ABC transporter
  • Ageing
  • Ageing of haematopoietic stem cells
  • Asymmetric cell division
  • Cancer progression
  • DNA damage
  • DNA repair
  • Human cell culture
  • Hypoxia
  • Oxidative stress
  • Stem cells
Collaborators
  • LPART24
  • prof dame linda partridge
  • DGEMS65
  • prof david gems
  • WSKHA12
  • mr wasim khan
  • MRDUC42
  • prof michael duchen
  • DMARS26
  • prof david marsh
  • RCHAR53
  • dr babis rallis
  • LFOUK88
  • dr lazaros foukas

Page last modified on 03 jul 13 14:22