The IHA is pleased to announce that former students Michael Shannack and Nattaphong Rattanavirotkul will both be starting PhD courses at Cambridge University this year. We wish them the best of luck in their studies! More...
Published: Sep 30, 2014 11:57:06 AM
Congratulations to IHA MRes students Michael Shannack, Nattaphong Rattanavirotkul, Adam Summerfield and Parina Patel. All four received a well-deserved Distinction in their Masters course. We wish them all the best for the future. More...
Published: Sep 19, 2014 3:20:37 PM
In their recent paper in PLOS Genetics Alic and co-workers explore the complex relationship between Drosophila foxo, a transcription factor with evolutionarily conserved role in ageing, and Anterior open, an ETS-family transcription factor that is a direct target of dFOXO in the adult gut and whose activation can extend lifespan.
The paper is entitled, "Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster"
View the article here: http://tinyurl.com/off4cqq More...
Published: Sep 19, 2014 9:58:55 AM
dr daniel pearce
- Room 325 Darwin Building
- Gower Street
- WC1E 6BT
- Genetics, Evolution & Environment
- Div of Biosciences
Stem cells have been found in most tissues/organs. These stem cells produce replacements for lost and damaged cells, and it is not completely understood how this regenerative capacity becomes diminished during ageing. One hypothesis is that stem cells are more likely to sacrifice themselves than risk potentially cancer-causing damage being passed onto progeny. This should reduce the incidence of cancer, but ultimately, may lead to a reduction in stem cells with age that contributes to the ageing process.
Current research aims include;
- Characterisation of age-based alterations in the phenotype and function of murine and human haematopoietic stem cells,
- Analysis of the role of haematopoietic stem cell-specific antitoxicity mechanisms during ageing
- Long-term tracking of the dynamics of age-based alterations in stem and progenitor cells
- Analysis of stem cell epigenetic alterations during ageing and how this alters gene expression
- Analysis of the effect of calorific restriction on murine haematopoietic stem ageing.
- Cell signalling
- The biology of ageing and the role of somatic stem cells in this process.
AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo.
Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells.
The combined use of Hoechst efflux ability and aldehyde dehydrogenase activity to identify murine and human hematopoietic stem cells.
Age dependent increase in SP distribution within Hematopoiesis: implications for our understanding of the mechanism of aging
Age-dependent increase in side population distribution within hematopoiesis: implications for our understanding of the mechanism of aging.
Out of the blue: a comparison of Hoechst side population (SP) analysis of murine bone marrow using 325, 363 and 407 nm excitation sources.
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- ABC transporter
- Ageing of haematopoietic stem cells
- Asymmetric cell division
- Cancer progression
- DNA damage
- DNA repair
- Human cell culture
- Oxidative stress
- Stem cells
- prof dame linda partridge
- prof david gems
- mr wasim khan
- prof michael duchen
- prof david marsh
- dr babis rallis
- dr lazaros foukas
Page last modified on 03 jul 13 14:22