A group of research staff and students from the IHA (Fiona Kerr, Teresa Niccoli, Nathan Woodling,
Oyinkansola Adesaki, Jorge Quan Castillo, Thomas Moens, Rubika Balendra)
recently appeared as part of the British Library's sold-out Memory
Matters event on Friday, October 30th.
Published: Nov 3, 2015 3:15:24 PM
'Anti-Ageing: Health or Beauty?' A guest blog by Jorge Ivan Castillo Quan, written for the 2015 Write About Research Competition.
Published: Jul 8, 2015 11:51:04 AM
Dr Marina Ezcurra and Dr Alex Benedetto were both selected to speak at the recent International C. elegans Meeting in Los Angeles (June 24th-28th). The two talks described new breakthroughs in understanding the mechanisms by which age-related pathologies originate in C. elegans, and generated considerable interest. Alex also described a new stress-resistance assay based on death fluorescence, recently discovered in the Gems lab. For details of the C. elegans International Meeting see http://www.genetics-gsa.org/celegans/2015/ More...
Published: Jul 7, 2015 11:01:37 AM
dr daniel pearce
- Room 325 Darwin Building
- Gower Street
- WC1E 6BT
- Genetics, Evolution & Environment
- Div of Biosciences
Stem cells have been found in most tissues/organs. These stem cells produce replacements for lost and damaged cells, and it is not completely understood how this regenerative capacity becomes diminished during ageing. One hypothesis is that stem cells are more likely to sacrifice themselves than risk potentially cancer-causing damage being passed onto progeny. This should reduce the incidence of cancer, but ultimately, may lead to a reduction in stem cells with age that contributes to the ageing process.
Research projects include;
- Analysis of the role of haematopoietic stem cell-specific anti-toxicity mechanisms during ageing
- Long-term tracking of the dynamics of age-based alterations in stem and progenitor cells
- Analysis of stem cell epigenetic alterations during ageing and how this alters gene expression
- Analysis of the effect of calorific restriction on murine haematopoietic stem ageing.
- Cell signalling
- The biology of ageing and the role of somatic stem cells in this process.
AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo.
Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells.
Age-dependent increase in side population distribution within hematopoiesis: implications for our understanding of the mechanism of aging.
Age dependent increase in SP distribution within Hematopoiesis: implications for our understanding of the mechanism of aging
The combined use of Hoechst efflux ability and aldehyde dehydrogenase activity to identify murine and human hematopoietic stem cells.
AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML
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- ABC transporter
- Ageing of haematopoietic stem cells
- Asymmetric cell division
- Cancer progression
- DNA damage
- DNA repair
- Human cell culture
- Oxidative stress
- Stem cells
- prof dame linda partridge
- prof david gems
- mr wasim khan
- prof michael duchen
- prof david marsh
- dr lazaros foukas
Page last modified on 03 jul 13 14:22