IHA Director Professor Linda Partridge is one of the organisers of the new Wellcome Trust Conference on Healthy Ageing being held 18-20 May 2015.
Ageing can lead to declining health and function, and it is the major risk factor for cancer, neurodegenerative and cardiovascular disease. This new Wellcome Trust conference will focus on recent discoveries and current challenges in ageing research, with a focus on translating basic research insights into health improvement for older people. We aim to explore the mechanisms of ageing in cells, tissues and organisms in order to identify interventions that can ameliorate its negative effects. The meeting will also emphasise the connection between discoveries made in model organisms and mechanisms leading to healthy ageing in humans.
The meeting is aimed at scientists, clinicians and drug developers involved in research into ageing and other relevant fields. We welcome the submission of abstracts from all areas relevant to the main themes of the meeting. Several oral presentations will be chosen from the abstracts submitted.
Topics will include: Human ageing Stem cells and cellular senescence, Physiology of homeostasis, Nutrition and metabolism, Genome stability, Epigenetics, Systems biology, Drug developmen. More...
Published: Mar 9, 2015 3:44:49 PM
Congratulations to Dr Nazif Alic whose paper has been published in the Royal Society's flagship biological research journal Proceedings B.
Published: Dec 18, 2014 5:19:24 PM
Published: Dec 4, 2014 11:04:44 AM
dr daniel pearce
- Room 325 Darwin Building
- Gower Street
- WC1E 6BT
- Genetics, Evolution & Environment
- Div of Biosciences
Stem cells have been found in most tissues/organs. These stem cells produce replacements for lost and damaged cells, and it is not completely understood how this regenerative capacity becomes diminished during ageing. One hypothesis is that stem cells are more likely to sacrifice themselves than risk potentially cancer-causing damage being passed onto progeny. This should reduce the incidence of cancer, but ultimately, may lead to a reduction in stem cells with age that contributes to the ageing process.
Current research aims include;
- Characterisation of age-based alterations in the phenotype and function of murine and human haematopoietic stem cells,
- Analysis of the role of haematopoietic stem cell-specific antitoxicity mechanisms during ageing
- Long-term tracking of the dynamics of age-based alterations in stem and progenitor cells
- Analysis of stem cell epigenetic alterations during ageing and how this alters gene expression
- Analysis of the effect of calorific restriction on murine haematopoietic stem ageing.
- Cell signalling
- The biology of ageing and the role of somatic stem cells in this process.
AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo.
Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells.
Age-dependent increase in side population distribution within hematopoiesis: implications for our understanding of the mechanism of aging.
The combined use of Hoechst efflux ability and aldehyde dehydrogenase activity to identify murine and human hematopoietic stem cells.
Age dependent increase in SP distribution within Hematopoiesis: implications for our understanding of the mechanism of aging
Development of a quantitative real-time polymerase chain reaction method for monitoring CEBPA mutations in normal karyotype acute myeloid leukaemia.
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- ABC transporter
- Ageing of haematopoietic stem cells
- Asymmetric cell division
- Cancer progression
- DNA damage
- DNA repair
- Human cell culture
- Oxidative stress
- Stem cells
- prof dame linda partridge
- prof david gems
- mr wasim khan
- prof michael duchen
- prof david marsh
- dr babis rallis
- dr lazaros foukas
Page last modified on 03 jul 13 14:22