A paper by researchers from the IHA Dr Cathy Slack and Dr Nazif Alic demonstrate new targets for drugs against ageing. Their research published in Cell shows how inhibition of the Ras-Erk-ETS pathway extends fly lifespan.
Published: Jun 26, 2015 10:42:55 AM
Watch the IHA's Dr Jorge Ivan Castillo Quan's talk on Anti-Aging. His fascinating talk was part of a very successful event called TEDx held at Goodenough College. More...
Published: Jun 17, 2015 12:38:48 PM
Research staff from the IHA's Partridge Lab, including Dr Jorge Ivan Castillo Quan and PhD student Ms Li Li, are among those whose work has recently been published in Brain. Their paper is entitled, "Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction".
Published: Jun 11, 2015 2:42:41 PM
dr daniel pearce
- Room 325 Darwin Building
- Gower Street
- WC1E 6BT
- Genetics, Evolution & Environment
- Div of Biosciences
Stem cells have been found in most tissues/organs. These stem cells produce replacements for lost and damaged cells, and it is not completely understood how this regenerative capacity becomes diminished during ageing. One hypothesis is that stem cells are more likely to sacrifice themselves than risk potentially cancer-causing damage being passed onto progeny. This should reduce the incidence of cancer, but ultimately, may lead to a reduction in stem cells with age that contributes to the ageing process.
Research projects include;
- Analysis of the role of haematopoietic stem cell-specific anti-toxicity mechanisms during ageing
- Long-term tracking of the dynamics of age-based alterations in stem and progenitor cells
- Analysis of stem cell epigenetic alterations during ageing and how this alters gene expression
- Analysis of the effect of calorific restriction on murine haematopoietic stem ageing.
- Cell signalling
- The biology of ageing and the role of somatic stem cells in this process.
AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo.
Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells.
The combined use of Hoechst efflux ability and aldehyde dehydrogenase activity to identify murine and human hematopoietic stem cells.
Age-dependent increase in side population distribution within hematopoiesis: implications for our understanding of the mechanism of aging.
Age dependent increase in SP distribution within Hematopoiesis: implications for our understanding of the mechanism of aging
Development of a quantitative real-time polymerase chain reaction method for monitoring CEBPA mutations in normal karyotype acute myeloid leukaemia.
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- ABC transporter
- Ageing of haematopoietic stem cells
- Asymmetric cell division
- Cancer progression
- DNA damage
- DNA repair
- Human cell culture
- Oxidative stress
- Stem cells
- prof dame linda partridge
- prof david gems
- mr wasim khan
- prof michael duchen
- prof david marsh
- dr babis rallis
- dr lazaros foukas
Page last modified on 03 jul 13 14:22