Congratulations and many thanks to Caroline Araiz and Melissa Cabecinha who recently competed in CRUK's 10k Race for Life in London. Not only did they exceed their £300 fundraising target but Caroline was the first runner to cross the line with an amazing time of 44m 21s and Melissa ran her first ever 10k!
Published: Jul 8, 2014 4:42:56 PM
Congratulations to the IHA's Sahar Emran who recently had a paper published in the journal Aging. Her paper shows how the drug rapamycin can overcome the lifespan shortening effects of eating a diet high in amino acids. The article can be viewed here.
Published: May 29, 2014 4:20:34 PM
The IHA's David Gems will feature in the upcoming episode of ‘Bang Goes the Theory’ which airs on Monday 31st March at 7.30pm on BBC1 and iPlayer. The episode focuses on ageing. http://www.bbc.co.uk/programmes/b00lwxj1 More...
Published: Mar 27, 2014 4:38:10 PM
dr daniel pearce
- Room 325 Darwin Building
- Gower Street
- WC1E 6BT
- Genetics, Evolution & Environment
- Div of Biosciences
Stem cells have been found in most tissues/organs. These stem cells produce replacements for lost and damaged cells, and it is not completely understood how this regenerative capacity becomes diminished during ageing. One hypothesis is that stem cells are more likely to sacrifice themselves than risk potentially cancer-causing damage being passed onto progeny. This should reduce the incidence of cancer, but ultimately, may lead to a reduction in stem cells with age that contributes to the ageing process.
Current research aims include;
- Characterisation of age-based alterations in the phenotype and function of murine and human haematopoietic stem cells,
- Analysis of the role of haematopoietic stem cell-specific antitoxicity mechanisms during ageing
- Long-term tracking of the dynamics of age-based alterations in stem and progenitor cells
- Analysis of stem cell epigenetic alterations during ageing and how this alters gene expression
- Analysis of the effect of calorific restriction on murine haematopoietic stem ageing.
- Cell signalling
- The biology of ageing and the role of somatic stem cells in this process.
AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo.
Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells.
The combined use of Hoechst efflux ability and aldehyde dehydrogenase activity to identify murine and human hematopoietic stem cells.
Age-dependent increase in side population distribution within hematopoiesis: implications for our understanding of the mechanism of aging.
Age dependent increase in SP distribution within Hematopoiesis: implications for our understanding of the mechanism of aging
Invalid Data from feed!
- ABC transporter
- Ageing of haematopoietic stem cells
- Asymmetric cell division
- Cancer progression
- DNA damage
- DNA repair
- Human cell culture
- Oxidative stress
- Stem cells
- prof dame linda partridge
- prof david gems
- dr eugene schuster
- mr wasim khan
- prof michael duchen
- prof david marsh
- dr babis rallis
- dr lazaros foukas
Page last modified on 03 jul 13 14:22