The IHA's Director Linda Partridge is one five contributors to publish a major review in Cell entitled 'The Hallmarks of Aging' (Cell, Volume 153, Issue 6, 1194-1217, 6 June 2013 doi:10.1016/j.cell.2013.05.039) More...
Published: Jun 7, 2013 10:01:32 AM
Warmest congratulations to Charlotte Beaver who passed her PhD viva yesterday. Charlotte has recently joined the IHA as a member of Dr Daniel Pearce's group.
Published: May 29, 2013 1:40:11 PM
Published: May 28, 2013 5:50:41 PM
dr daniel pearce
- Room 325 Darwin Building
- Gower Street
- WC1E 6BT
- Genetics, Evolution & Environment
- Div of Biosciences
Stem cells have been found in most tissues/organs. These stem cells produce replacements for lost and damaged cells, and it is not completely understood how this regenerative capacity becomes diminished during ageing. One hypothesis is that stem cells are more likely to sacrifice themselves than risk potentially cancer-causing damage being passed onto progeny. This should reduce the incidence of cancer, but ultimately, may lead to a reduction in stem cells with age that contributes to the ageing process.
Current research aims include;
- Characterisation of age-based alterations in the phenotype and function of murine and human haematopoietic stem cells,
- Analysis of the role of haematopoietic stem cell-specific antitoxicity mechanisms during ageing
- Long-term tracking of the dynamics of age-based alterations in stem and progenitor cells
- Analysis of stem cell epigenetic alterations during ageing and how this alters gene expression
- Analysis of the effect of calorific restriction on murine haematopoietic stem ageing.
- Cell signalling
- The biology of ageing and the role of somatic stem cells in this process.
AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo.
Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells.
Age dependent increase in SP distribution within Hematopoiesis: implications for our understanding of the mechanism of aging
The combined use of Hoechst efflux ability and aldehyde dehydrogenase activity to identify murine and human hematopoietic stem cells.
Age-dependent increase in side population distribution within hematopoiesis: implications for our understanding of the mechanism of aging.
AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML
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- ABC transporter
- Ageing of haematopoietic stem cells
- Asymmetric cell division
- Cancer progression
- DNA damage
- DNA repair
- Human cell culture
- Oxidative stress
- Stem cells
- prof linda partridge
- prof david gems
- dr eugene schuster
- mr wasim khan
- prof michael duchen
- prof david marsh
- dr babis rallis
- dr lazaros foukas
Page last modified on 29 apr 13 15:07