The death fluorescence study provoked some interest from the news media,
both nationally and internationally. At home, it was covered by New
Scientist (online), and small items appeared in the Daily Mail, and
Metro (London). There was more interest in the USA, where David Gems was
interviewed for the National Public Radio programme “All Things
Considered” (similar to the Today programme on R4), and the story was
covered by Scientific American (online) and The Scientist. More widely,
the story was covered by news media in France, Canada (in the
publication "Vice"), Sweden, Romania (where there was a colourful TV
news item), Ghana, China and Indonesia. More...
Published: Sep 9, 2013 4:22:23 PM
Sunday Times Magazine, August 25th 2013.
Published: Aug 27, 2013 12:18:45 PM
We are pleased to announce that the Epigenetics journal have accepted Daniel Pearce, Stephan Beck and Tosin Taiwo's paper for publication. The article's title is "DNA methylation analysis of murine haematopoietic side population cells during ageing." For more information please contact Dr Pearce.
Published: Aug 6, 2013 11:02:17 AM
dr daniel pearce
- Room 325 Darwin Building
- Gower Street
- WC1E 6BT
- Genetics, Evolution & Environment
- Div of Biosciences
Stem cells have been found in most tissues/organs. These stem cells produce replacements for lost and damaged cells, and it is not completely understood how this regenerative capacity becomes diminished during ageing. One hypothesis is that stem cells are more likely to sacrifice themselves than risk potentially cancer-causing damage being passed onto progeny. This should reduce the incidence of cancer, but ultimately, may lead to a reduction in stem cells with age that contributes to the ageing process.
Current research aims include;
- Characterisation of age-based alterations in the phenotype and function of murine and human haematopoietic stem cells,
- Analysis of the role of haematopoietic stem cell-specific antitoxicity mechanisms during ageing
- Long-term tracking of the dynamics of age-based alterations in stem and progenitor cells
- Analysis of stem cell epigenetic alterations during ageing and how this alters gene expression
- Analysis of the effect of calorific restriction on murine haematopoietic stem ageing.
- Cell signalling
- The biology of ageing and the role of somatic stem cells in this process.
AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo.
Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells.
Age-dependent increase in side population distribution within hematopoiesis: implications for our understanding of the mechanism of aging.
Age dependent increase in SP distribution within Hematopoiesis: implications for our understanding of the mechanism of aging
The combined use of Hoechst efflux ability and aldehyde dehydrogenase activity to identify murine and human hematopoietic stem cells.
Out of the blue: a comparison of Hoechst side population (SP) analysis of murine bone marrow using 325, 363 and 407 nm excitation sources.
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- ABC transporter
- Ageing of haematopoietic stem cells
- Asymmetric cell division
- Cancer progression
- DNA damage
- DNA repair
- Human cell culture
- Oxidative stress
- Stem cells
- prof linda partridge
- prof david gems
- dr eugene schuster
- mr wasim khan
- prof michael duchen
- prof david marsh
- dr babis rallis
- dr lazaros foukas
Page last modified on 03 jul 13 14:22