Congratulations to the IHA's Dr Jorge Iván Castillo Quan who last week was awarded 1st prize for best poster/presentation at the UCL Faculty of Brain Sciences Symposium. This follows his earlier success at UCL Faculty of Life Sciences Research Day held in September 2013, where he also won 1st prize. Well done Jorge!
Published: Feb 25, 2014 3:24:12 PM
PLOS Genetics paper published today "DAF-16/FoxO Directly Regulates an Atypical AMP- Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in Caenorhabditis elegans"
Congratulations to first author Dr Jennifer M. Tullet and her IHA colleagues whose paper was published in PLOS Genetics today.
Published: Feb 7, 2014 11:49:04 AM
Cell Reports today published an article by several of the IHA's researchers, including first author Dr Nazif Alic. The open-access article can be found here: http://www.cell.com/cell-reports/fulltext/S2211-1247%2814%2900032-1 More...
Published: Feb 7, 2014 11:37:42 AM
dr daniel pearce
- Room 325 Darwin Building
- Gower Street
- WC1E 6BT
- Genetics, Evolution & Environment
- Div of Biosciences
Stem cells have been found in most tissues/organs. These stem cells produce replacements for lost and damaged cells, and it is not completely understood how this regenerative capacity becomes diminished during ageing. One hypothesis is that stem cells are more likely to sacrifice themselves than risk potentially cancer-causing damage being passed onto progeny. This should reduce the incidence of cancer, but ultimately, may lead to a reduction in stem cells with age that contributes to the ageing process.
Current research aims include;
- Characterisation of age-based alterations in the phenotype and function of murine and human haematopoietic stem cells,
- Analysis of the role of haematopoietic stem cell-specific antitoxicity mechanisms during ageing
- Long-term tracking of the dynamics of age-based alterations in stem and progenitor cells
- Analysis of stem cell epigenetic alterations during ageing and how this alters gene expression
- Analysis of the effect of calorific restriction on murine haematopoietic stem ageing.
- Cell signalling
- The biology of ageing and the role of somatic stem cells in this process.
AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo.
Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells.
The combined use of Hoechst efflux ability and aldehyde dehydrogenase activity to identify murine and human hematopoietic stem cells.
Age-dependent increase in side population distribution within hematopoiesis: implications for our understanding of the mechanism of aging.
Age dependent increase in SP distribution within Hematopoiesis: implications for our understanding of the mechanism of aging
AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML
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- ABC transporter
- Ageing of haematopoietic stem cells
- Asymmetric cell division
- Cancer progression
- DNA damage
- DNA repair
- Human cell culture
- Oxidative stress
- Stem cells
- prof linda partridge
- prof david gems
- dr eugene schuster
- mr wasim khan
- prof michael duchen
- prof david marsh
- dr babis rallis
- dr lazaros foukas
Page last modified on 03 jul 13 14:22