A paper by researchers from the IHA Dr Cathy Slack and Dr Nazif Alic demonstrate new targets for drugs against ageing. Their research published in Cell shows how inhibition of the Ras-Erk-ETS pathway extends fly lifespan.
Published: Jun 26, 2015 10:42:55 AM
Watch the IHA's Dr Jorge Ivan Castillo Quan's talk on Anti-Aging. His fascinating talk was part of a very successful event called TEDx held at Goodenough College. More...
Published: Jun 17, 2015 12:38:48 PM
Research staff from the IHA's Partridge Lab, including Dr Jorge Ivan Castillo Quan and PhD student Ms Li Li, are among those whose work has recently been published in Brain. Their paper is entitled, "Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction".
Published: Jun 11, 2015 2:42:41 PM
Aims of the Partridge Lab
The aim of our research is to discover genes and
mechanisms that determine the rate of ageing. We collaborate with
other laboratories to determine if these processes show evolutionary
conservation. Most of our work is conducted with the fruit fly Drosophila melanogaster through comparison with C.elegans and then with the mouse.
Our work focuses particularly on the insulin/IGF-like signalling pathway, dietary restriction and resistance to stress. We are interested also in the physiological mechanisms that force organisms to make trade-offs, such as that between high nutrient intake and high reproductive rate, on one hand and slow ageing on the other.
Our work is financed by The Wellcome Trust, the European Commission, ERC, MRC, The Alzheimer's Research UK, The Glenn Foundation, Age UK and the Max Planck Institute.
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