Congratulations to Dr Teresa Niccoli whose paper "Increased Glucose Transport into Neurons Rescues Ab Toxicity in Drosophila" has just been published in Current Biology by Cell Press. More...
Published: Aug 17, 2016 3:05:35 PM
The Institute of Healthy Ageing is currently seeking a post-doctoral research associate to work on the following ARUK-funded project.
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating, mid-life, neurodegenerative disorders for which no cure is currently available. Large expansions of a hexanucleotide GGGGCC-repeat in the first intron of the C9orf72 gene is the most common genetic cause of both ALS and FTD. We recently developed novel Drosophila models of C9orf72 repeat-induced neurodegeneration (Mizielinska et al Science 2014, 345:1192-1194).
This 3-year post-doctoral position will build on this work by investigating disease mechanisms in a range of C9orf72 fly lines using several approaches including genome-wide transcriptomic and translational analyses in both flies and iPSC-neurons. You will work as part of a collaborative team of investigators in the excellent and supportive scientific research community of UCL.
The post is funded for 3 years in the first instance by Alzheimer’s Research UK and is available from October 2016.
For full information and to apply please visit the UCL website at https://goo.gl/E5vk8j
Published: Aug 11, 2016 2:27:25 PM
Until recently an EU-funded postdoc in David Gems's lab, Alex Benedetto will shortly set up his own laboratory at the University of Lancaster, in the Department of Biomedical and Life Sciences. There he will continue his investigations of the biology of ageing in model organisms, particularly C. elegans. We wish Alex all the best in setting up his new lab! More...
Published: Jul 20, 2016 2:10:01 PM
Aims of the Partridge Lab
The aim of our research is to discover genes and
mechanisms that determine the rate of ageing. We collaborate with
other laboratories to determine if these processes show evolutionary
conservation. Most of our work is conducted with the fruit fly Drosophila melanogaster through comparison with C.elegans and then with the mouse.
Our work focuses particularly on the insulin/IGF-like signalling pathway, dietary restriction and resistance to stress. We are interested also in the physiological mechanisms that force organisms to make trade-offs, such as that between high nutrient intake and high reproductive rate, on one hand and slow ageing on the other.
Our work is financed by the Wellcome Trust, the European Commission, ERC, MRC, Alzheimer's Research UK, Parkinsons' UK, The Glenn Foundation, Age UK and the Max Planck Institute.
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