- Nazif Alic
- A Scholar's Life for me
- A Visit from Glenlola Collegiate School
- Arne Akbar
- Nature Paper published
- Changing of the Guard in C. elegans lab
- Holiday School Visit
- Congratulations to Li Li
- Thanks from Nature...
- Gordon Research Conference 2012
- Darwin's Birthday Party 2012
- Congratulations Tosin ...
- Well Done Sahar!
- Royal Society Summer Science Exhibition 2012
- Cheltenham Science Festival 2012
- Congratulations to Dr Matt Piper ...
- Ekin Bolukbasi - Chicago Conference
- Matt Piper - Lisbon
- Helena Cocheme - Nature Protocols paper
- Congratulations to Dr Daniel Pearce ...
- David Gems - Moscow conference
- Jorge Ivan Castillo-Quan
- IHA - success for our students
- RS SSE 2012 - 'Why Fly?'
- Congratulations to Sahar Emran ...
- Fiona Kerr - Alzheimer's Association International Conference highlights
- New WT Senior Research Fellow post in the IHA
- IHA at the Royal Society Summer Science Exhibition 2012
- Congratulations to Professor David Gems
- A bientot Matt and Bill
- Hearing impaired students visit the IHA
- Healthy Ageing exhibition news
- Congratulations to Dr Ivana Bjedov
- New WTSA for the IHA!!
- New roles for the Partridge and Gems labs
- PLoS One paper for Dr Cathy Slack
- 3 year Bioinformatics PhD studentship now available
- Congratulations to Dr Nuria Vergara
- Welcome to Michael Wright ...
- Sahar Emran awarded bursary by Biochemical Society
- MRes in Biology of Ageing and Age-related disease
- Watch Dr Matt Piper's Lunchtime Lecture
- Explore Ageing Research with Dr Matt Piper at the Royal Society Café Scientifique
- Wellcome Trust Packed Lunch Podcast with Dr Matt Piper
- Watch the IHA Harlem Shake!
- Gems Lab News Winter Roundup
- Dr Jennifer Regan: Immunity, Ageing and Gender – Why is Life Deadlier for the Male? March 22nd
- Congratulations to Tosin Taiwo
- Carolina Soto Palma to attend The Times Cheltenham Science Festival
- Giovanna Vinti awarded UCL Green Impact Award
- IHA Race for Life teams kicks off with Bake Sale
- Hear Prof Dame Linda Partridge speak on BBC Radio 4's Life Scientific
- Congratulations to Charlotte Beaver on passing her PhD viva!
- Cell Review: The Hallmarks of Aging
The IHA's Director Linda Partridge is one five contributors to publish a major review in Cell entitled 'The Hallmarks of Aging' (Cell, Volume 153, Issue 6, 1194-1217, 6 June 2013 doi:10.1016/j.cell.2013.05.039) More...
Published: Jun 7, 2013 10:01:32 AM
Warmest congratulations to Charlotte Beaver who passed her PhD viva yesterday. Charlotte has recently joined the IHA as a member of Dr Daniel Pearce's group.
Published: May 29, 2013 1:40:11 PM
Published: May 28, 2013 5:50:41 PM
PLoS One paper for Dr Cathy Slack
25 October 2012
Congratulations to Dr Cathy Slack (Partridge Laboratory) on the publication of her paper 'Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin is insufficient to Extend Lifespan in Drosophila' in PLoS One.
The biguanide drug, metformin, commonly used to treat type-2 diabetes, has been shown to extend lifespan and reduce fecundity in C. elegans through a dietary restriction-like mechanism via the AMP-activated protein kinase (AMPK) and the AMPK-activating kinase, LKB1. We have investigated whether the longevity-promoting effects of metformin are evolutionarily conserved using the fruit fly, Drosophila melanogaster. We show here that while feeding metformin to adult Drosophila resulted in a robust activation of AMPK and reduced lipid stores, it did not increase lifespan in either male or female flies. In fact, we found that when administered at high concentrations, metformin is toxic to flies. Furthermore, no decreases in female fecundity were observed except at the most toxic dose. Analysis of intestinal physiology after metformin treatment suggests that these deleterious effects may result from disruptions to intestinal fluid homeostasis. Thus, metformin appears to have evolutionarily conserved effects on metabolism but not on fecundity or lifespan.
Page last modified on 25 oct 12 15:26