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Science Paper published

A recent Science article published by a team of UCL researchers including the IHA's Dr Teresa Niccoli sheds light into toxicity mechanisms. View the article here: http://goo.gl/2sgNCb More...

Published: Aug 19, 2014 10:24:04 AM

Knudra Transgenics prize success for IHA

In a recent competition organised by the biotech company KNUDRA TRANSGENICS three members of the IHA were awarded prizes to make custom transgenic animals.

Second prize $3000 to Nuria Vergara to develop the project "Can human FOXO3a replace DAF-16 to promote longevity in C. elegans?" using CRSPR technology.

Third prize £1500 to Jennifer Tullet to investigate "How do translational errors affect longevity and health in C. elegans?"

Sixth prize $500 to Lamia Mestek to expand our knowledge in "Understanding the role of DAF-16 transcription factor in longevity"

The results of the competition can be checked in the following link: http://knudragrants.knudra.com/?page_id=39

Congratulations to all the winners!!!
More...

Published: Aug 19, 2014 10:10:57 AM

New Wellcome Trust video 'Until' features IHA scientists

The Wellcome Trust’s online publication, Mosaic, have released a new video ‘Until’, an exploration of ageing which asks the question, ‘how long would you like to live?’. The video includes interviews with leading ageing scientists (including the IHA's David Gems and Linda Partridge), transhumanists, elderly people and the young children and asks them when they think would be an appropriate time to die, if they had the choice. It also explores the possibilities and realities of extended lifespans in the future. The video can be found here: http://youtu.be/BsUZHyh4n-c More...

Published: Aug 6, 2014 11:44:15 AM

PLoS One paper for Dr Cathy Slack

25 October 2012

Congratulations to Dr Cathy Slack (Partridge Laboratory) on the publication of her paper 'Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin is insufficient to Extend Lifespan in Drosophila' in PLoS One.

Abstract -
The biguanide drug, metformin, commonly used to treat type-2 diabetes, has been shown to extend lifespan and reduce fecundity in C. elegans through a dietary restriction-like mechanism via the AMP-activated protein kinase (AMPK) and the AMPK-activating kinase, LKB1. We have investigated whether the longevity-promoting effects of metformin are evolutionarily conserved using the fruit fly, Drosophila melanogaster. We show here that while feeding metformin to adult Drosophila resulted in a robust activation of AMPK and reduced lipid stores, it did not increase lifespan in either male or female flies. In fact, we found that when administered at high concentrations, metformin is toxic to flies. Furthermore, no decreases in female fecundity were observed except at the most toxic dose. Analysis of intestinal physiology after metformin treatment suggests that these deleterious effects may result from disruptions to intestinal fluid homeostasis. Thus, metformin appears to have evolutionarily conserved effects on metabolism but not on fecundity or lifespan.

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