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CNN news: How long can humans live?

Following her BBC interview Professor Linda Partridge spoke with CNN's Bianca Britton, whose article asks, "how long can humans live?" More...

Published: Oct 6, 2016 3:07:38 PM

Linda Partridge interviewed for BBC News on Vijg Nature Paper

On Wednesday, October 5 2016 IHA Director Professor Linda Partridge was interviewed on the BBC 6 O'Clock News about the recent Nature paper by Jan Vijg. The Nature paper entitled "Evidence for a limit to human lifespan" suggests a maximum upper age limit for humans and Prof Partridge was asked to comment on this.

Published: Oct 6, 2016 11:58:50 AM

Linda Partridge and the IHA feature interview with Time Out London

Professor Linda Partridge was recently interviewed by Time Out London and features in today's issue ('Rad Scientists', Time Out, 20/09/2016). You can read the article via our Facebook site at https://www.facebook.com/UCLInstituteofHealthyAgeing/

Published: Sep 20, 2016 11:43:25 AM

PLoS One paper for Dr Cathy Slack

25 October 2012

Congratulations to Dr Cathy Slack (Partridge Laboratory) on the publication of her paper 'Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin is insufficient to Extend Lifespan in Drosophila' in PLoS One.

Abstract -
The biguanide drug, metformin, commonly used to treat type-2 diabetes, has been shown to extend lifespan and reduce fecundity in C. elegans through a dietary restriction-like mechanism via the AMP-activated protein kinase (AMPK) and the AMPK-activating kinase, LKB1. We have investigated whether the longevity-promoting effects of metformin are evolutionarily conserved using the fruit fly, Drosophila melanogaster. We show here that while feeding metformin to adult Drosophila resulted in a robust activation of AMPK and reduced lipid stores, it did not increase lifespan in either male or female flies. In fact, we found that when administered at high concentrations, metformin is toxic to flies. Furthermore, no decreases in female fecundity were observed except at the most toxic dose. Analysis of intestinal physiology after metformin treatment suggests that these deleterious effects may result from disruptions to intestinal fluid homeostasis. Thus, metformin appears to have evolutionarily conserved effects on metabolism but not on fecundity or lifespan.

Page last modified on 25 oct 12 15:26