IHA Logo
IHA News

Follow us:

find_us_on_facebook
twitter
A A A
Feed icon

IHA News

Help support the IHA Race for Life team!

An IHA team led by lab technician Melissa Cabecinha will be running 5km around Regent's Park on Saturday, May 30th as part of CRUK's Race for Life challenge.

If you would like to support our team by making a donation please visit Melissa's fundraising page at: https://www.justgiving.com/iha-ladies

Thank you! More...

Published: May 5, 2015 11:57:57 AM

Wellcome Trust Conference - Healthy Ageing: From Molecules to Organisms

IHA Director Professor Linda Partridge is one of the organisers of the new Wellcome Trust Conference on Healthy Ageing being held 18-20 May 2015.
https://registration.hinxton.wellcome.ac.uk/display_info.asp?id=467

Ageing can lead to declining health and function, and it is the major risk factor for cancer, neurodegenerative and cardiovascular disease. This new Wellcome Trust conference will focus on recent discoveries and current challenges in ageing research, with a focus on translating basic research insights into health improvement for older people. We aim to explore the mechanisms of ageing in cells, tissues and organisms in order to identify interventions that can ameliorate its negative effects. The meeting will also emphasise the connection between discoveries made in model organisms and mechanisms leading to healthy ageing in humans.

The meeting is aimed at scientists, clinicians and drug developers involved in research into ageing and other relevant fields. We welcome the submission of abstracts from all areas relevant to the main themes of the meeting. Several oral presentations will be chosen from the abstracts submitted.

Topics will include: Human ageing Stem cells and cellular senescence, Physiology of homeostasis, Nutrition and metabolism, Genome stability, Epigenetics, Systems biology, Drug developmen. More...

Published: Mar 9, 2015 3:44:49 PM

Dr Nazif Alic paper published in Royal Society Proceedings B

Congratulations to Dr Nazif Alic whose paper has been published in the Royal Society's flagship biological research journal Proceedings B.
More...

Published: Dec 18, 2014 5:19:24 PM

PLoS One paper for Dr Cathy Slack

25 October 2012

Congratulations to Dr Cathy Slack (Partridge Laboratory) on the publication of her paper 'Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin is insufficient to Extend Lifespan in Drosophila' in PLoS One.

Abstract -
The biguanide drug, metformin, commonly used to treat type-2 diabetes, has been shown to extend lifespan and reduce fecundity in C. elegans through a dietary restriction-like mechanism via the AMP-activated protein kinase (AMPK) and the AMPK-activating kinase, LKB1. We have investigated whether the longevity-promoting effects of metformin are evolutionarily conserved using the fruit fly, Drosophila melanogaster. We show here that while feeding metformin to adult Drosophila resulted in a robust activation of AMPK and reduced lipid stores, it did not increase lifespan in either male or female flies. In fact, we found that when administered at high concentrations, metformin is toxic to flies. Furthermore, no decreases in female fecundity were observed except at the most toxic dose. Analysis of intestinal physiology after metformin treatment suggests that these deleterious effects may result from disruptions to intestinal fluid homeostasis. Thus, metformin appears to have evolutionarily conserved effects on metabolism but not on fecundity or lifespan.

Page last modified on 25 oct 12 15:26