IHA Logo
IHA News
A A A

IHA News

Race for Life!

Congratulations and many thanks to Caroline Araiz and Melissa Cabecinha who recently competed in CRUK's 10k Race for Life in London. Not only did they exceed their £300 fundraising target but Caroline was the first runner to cross the line with an amazing time of 44m 21s and Melissa ran her first ever 10k!
More...

Published: Jul 8, 2014 4:42:56 PM

Sahar Emran has paper published in Aging

Congratulations to the IHA's Sahar Emran who recently had a paper published in the journal Aging. Her paper shows how the drug rapamycin can overcome the lifespan shortening effects of eating a diet high in amino acids. The article can be viewed here.

More...

Published: May 29, 2014 4:20:34 PM

Prof David Gems on BBC1's 'Bang Goes The Theory' 31/03/2014

The IHA's David Gems will feature in the upcoming episode of  ‘Bang Goes the Theory’ which airs on Monday 31st March at 7.30pm on BBC1 and iPlayer. The episode focuses on ageing. http://www.bbc.co.uk/programmes/b00lwxj1 More...

Published: Mar 27, 2014 4:38:10 PM

PLoS One paper for Dr Cathy Slack

25 October 2012

Congratulations to Dr Cathy Slack (Partridge Laboratory) on the publication of her paper 'Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin is insufficient to Extend Lifespan in Drosophila' in PLoS One.

Abstract -
The biguanide drug, metformin, commonly used to treat type-2 diabetes, has been shown to extend lifespan and reduce fecundity in C. elegans through a dietary restriction-like mechanism via the AMP-activated protein kinase (AMPK) and the AMPK-activating kinase, LKB1. We have investigated whether the longevity-promoting effects of metformin are evolutionarily conserved using the fruit fly, Drosophila melanogaster. We show here that while feeding metformin to adult Drosophila resulted in a robust activation of AMPK and reduced lipid stores, it did not increase lifespan in either male or female flies. In fact, we found that when administered at high concentrations, metformin is toxic to flies. Furthermore, no decreases in female fecundity were observed except at the most toxic dose. Analysis of intestinal physiology after metformin treatment suggests that these deleterious effects may result from disruptions to intestinal fluid homeostasis. Thus, metformin appears to have evolutionarily conserved effects on metabolism but not on fecundity or lifespan.

Page last modified on 25 oct 12 15:26