IHA Logo
IHA News

Follow us:

find_us_on_facebook
twitter
A A A

IHA News

Dr Nazif Alic paper published in Royal Society Proceedings B

Congratulations to Dr Nazif Alic whose paper has been published in the Royal Society's flagship biological research journal Proceedings B.
More...

Published: Dec 18, 2014 5:19:24 PM

Linda Partridge to speak at Nobel Week Dialogue, Live streaming and Q&A

Join in the digital discussion on ageing with IHA Director Linda Partridge as part of this year's Nobel Week Dialogue on 9th December.  More...

Published: Dec 4, 2014 11:04:44 AM

IHA Director Prof Linda Partridge honoured with BBSRC Excellence Award

IHA Director, Professor Linda Partridge, has been recognised with a BBSRC Anniversary Award for Excellence in Bioscience.

The Biotechnology and Biological Sciences Research Council (BBSRC) has recognised outstanding contributions to bioscience made by four of its research community. As part of BBSRC’s 20th anniversary, the awards demonstrate pride for the UK's world-leading bioscience research base and the impact it has achieved in the last two decades.

The awards will be presented at the Great British Bioscience Festival in November.

Professor Jackie Hunter, BBSRC Chief Executive, said: "Our 20th anniversary year is the perfect time to acknowledge and celebrate the achievements of researchers that BBSRC has supported. These awards highlight outstanding achievements that benefit us all and help to make the UK world-leading in bioscience."

Congratulations Linda!
More...

Published: Nov 7, 2014 4:31:19 PM

PLoS One paper for Dr Cathy Slack

25 October 2012

Congratulations to Dr Cathy Slack (Partridge Laboratory) on the publication of her paper 'Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin is insufficient to Extend Lifespan in Drosophila' in PLoS One.

Abstract -
The biguanide drug, metformin, commonly used to treat type-2 diabetes, has been shown to extend lifespan and reduce fecundity in C. elegans through a dietary restriction-like mechanism via the AMP-activated protein kinase (AMPK) and the AMPK-activating kinase, LKB1. We have investigated whether the longevity-promoting effects of metformin are evolutionarily conserved using the fruit fly, Drosophila melanogaster. We show here that while feeding metformin to adult Drosophila resulted in a robust activation of AMPK and reduced lipid stores, it did not increase lifespan in either male or female flies. In fact, we found that when administered at high concentrations, metformin is toxic to flies. Furthermore, no decreases in female fecundity were observed except at the most toxic dose. Analysis of intestinal physiology after metformin treatment suggests that these deleterious effects may result from disruptions to intestinal fluid homeostasis. Thus, metformin appears to have evolutionarily conserved effects on metabolism but not on fecundity or lifespan.

Page last modified on 25 oct 12 15:26