UCL Institute of Healthy Ageing IHA News
- Nazif Alic
- A Scholar's Life for me
- A Visit from Glenlola Collegiate School
- Arne Akbar
- Nature Paper published
- Changing of the Guard in C. elegans lab
- Holiday School Visit
- Congratulations to Li Li
- Thanks from Nature...
- Gordon Research Conference 2012
- Darwin's Birthday Party 2012
- Congratulations Tosin ...
- Well Done Sahar!
- Royal Society Summer Science Exhibition 2012
- Cheltenham Science Festival 2012
- Congratulations to Dr Matt Piper ...
- Ekin Bolukbasi - Chicago Conference
- Matt Piper - Lisbon
- Helena Cocheme - Nature Protocols paper
- Congratulations to Dr Daniel Pearce ...
- David Gems - Moscow conference
- Jorge Ivan Castillo-Quan
- IHA - success for our students
- RS SSE 2012 - 'Why Fly?'
- Congratulations to Sahar Emran ...
- Fiona Kerr - Alzheimer's Association International Conference highlights
- New WT Senior Research Fellow post in the IHA
- IHA at the Royal Society Summer Science Exhibition 2012
- Congratulations to Professor David Gems
- A bientot Matt and Bill
- Hearing impaired students visit the IHA
- Healthy Ageing exhibition news
- Congratulations to Dr Ivana Bjedov
- New WTSA for the IHA!!
- New roles for the Partridge and Gems labs
- PLoS One paper for Dr Cathy Slack
- 3 year Bioinformatics PhD studentship now available
- Congratulations to Dr Nuria Vergara
- Welcome to Michael Wright ...
- Sahar Emran awarded bursary by Biochemical Society
- MRes in Biology of Ageing and Age-related disease
- Watch Dr Matt Piper's Lunchtime Lecture
- Explore Ageing Research with Dr Matt Piper at the Royal Society Café Scientifique
- Wellcome Trust Packed Lunch Podcast with Dr Matt Piper
- Watch the IHA Harlem Shake!
- Gems Lab News Winter Roundup
- Dr Jennifer Regan: Immunity, Ageing and Gender – Why is Life Deadlier for the Male? March 22nd
- Congratulations to Tosin Taiwo
- Carolina Soto Palma to attend The Times Cheltenham Science Festival
- Giovanna Vinti awarded UCL Green Impact Award
- IHA Race for Life teams kicks off with Bake Sale
- Hear Prof Dame Linda Partridge speak on BBC Radio 4's Life Scientific
- Congratulations to Charlotte Beaver on passing her PhD viva!
- Cell Review: The Hallmarks of Aging
- Analysing Variation in Drosophila Ageing Across Independent Experimental Studies
- Congratulations to the IHA Race for Life team
- Cassandra Coburn discusses her PLOS Biology paper on Romanian TV
- Gems Lab News Summer Roundup
- Daniel Pearce, Stephan Beck and Tosin Taiwo paper to be published in Epigenetics
- Prof Dame Linda Partridge features in 'A Life in the Day', Sunday Times Magazine
- More coverage on Death Fluorescence in the news
- Crick Late at the Science Museum
- I'm a Scientist, Get me out of here!
- Gems Lab News - Winter Roundup
- Watch the IHA's Dr Oyinkansola Adesakin discuss her Alzheimer's Society Fellowship
- Cell Reports paper published "Cell-Nonautonomous Effects of dFOXO/DAF-16 in Aging"
- PLOS Genetics paper published today "DAF-16/FoxO Directly Regulates an Atypical AMP- Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in Caenorhabditis elegans"
- Dr Jorge Iván Castillo Quan receives Faculty Prize
- 4 year PhD studentship in the IHA available
- Prof David Gems on BBC1's 'Bang Goes The Theory' 31/03/2014
- Sahar Emran has paper published in Aging
- Race for Life!
- New Wellcome Trust video 'Until' features IHA scientists
- Knudra Transgenics prize success for IHA
- Science Paper published
- Congratulations to Adam Dobson
- Gems Lab Summer Roundup
- Dr Nazif Alic paper published in PLOS Genetics
- IHA MRes students to receive Distinctions in their degrees!
- Dr Nazif Alic on the The Naked Scientists
- IHA Director Prof Linda Partridge honoured with BBSRC Excellence Award
- Linda Partridge to speak at Nobel Week Dialogue, Live streaming and Q&A
- Dr Nazif Alic paper published in Royal Society Proceedings B
- Wellcome Trust Conference - Healthy Ageing: From Molecules to Organisms
- Help support the IHA Race for Life team!
- Brain paper published by Partridge Lab
- Dr Jorge Ivan Castillo Quan - Anti-Aging: Beauty or Health?
- New article by David Gems!
- Institute of Healthy Ageing hosts BSRA Annual Meeting
- Talks from Gems Lab at International C. elegans Meeting
- Cell paper reveals how a cancer drug makes fruit flies live longer
- Jorge Ivan Castillo Quan on Anti-Ageing research
- Memory Matters at the British Library
- Dr Jennifer Regan's paper on sex difference in ageing gut pathology published in eLIFE
- Congratulations to Dr Jorge Ivan Castillo Quan on his Cell Reports paper
Congratulations to Dr Jorge Ivan Castillo Quan whose paper in Cell Reports was published today. His research, which was carried out during his PhD studies at the Institute of Healthy Ageing, demonstrates that fruit flies live 16% longer than average when given low doses of the mood stabiliser lithium. More...
Published: Apr 7, 2016 5:01:10 PM
Congratulation to the IHA's Dr Jennifer Regan whose paper on sex difference in the pathology of ageing gut has just been published in the eLIFE journal.
Published: Feb 17, 2016 11:35:55 AM
A group of research staff and students from the IHA (Fiona Kerr, Teresa Niccoli, Nathan Woodling,
Oyinkansola Adesaki, Jorge Quan Castillo, Thomas Moens, Rubika Balendra)
recently appeared as part of the British Library's sold-out Memory
Matters event on Friday, October 30th.
Published: Nov 3, 2015 3:15:24 PM
PLoS One paper for Dr Cathy Slack
25 October 2012
Congratulations to Dr Cathy Slack (Partridge Laboratory) on the publication of her paper 'Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin is insufficient to Extend Lifespan in Drosophila' in PLoS One.
The biguanide drug, metformin, commonly used to treat type-2 diabetes, has been shown to extend lifespan and reduce fecundity in C. elegans through a dietary restriction-like mechanism via the AMP-activated protein kinase (AMPK) and the AMPK-activating kinase, LKB1. We have investigated whether the longevity-promoting effects of metformin are evolutionarily conserved using the fruit fly, Drosophila melanogaster. We show here that while feeding metformin to adult Drosophila resulted in a robust activation of AMPK and reduced lipid stores, it did not increase lifespan in either male or female flies. In fact, we found that when administered at high concentrations, metformin is toxic to flies. Furthermore, no decreases in female fecundity were observed except at the most toxic dose. Analysis of intestinal physiology after metformin treatment suggests that these deleterious effects may result from disruptions to intestinal fluid homeostasis. Thus, metformin appears to have evolutionarily conserved effects on metabolism but not on fecundity or lifespan.
Page last modified on 25 oct 12 15:26