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Dr Nazif Alic on the The Naked Scientists

Nazif Alic talks about healthspan and healthy ageing on The Naked Scientists.
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Published: Oct 24, 2014 10:40:42 AM

Former IHA students start PhD's at Cambridge University

The IHA is pleased to announce that former students Michael Shannack and Nattaphong Rattanavirotkul will both be starting PhD courses at Cambridge University this year. We wish them the best of luck in their studies! More...

Published: Sep 30, 2014 11:57:06 AM

IHA MRes students to receive Distinctions in their degrees!

Congratulations to IHA MRes students Michael Shannack, Nattaphong Rattanavirotkul, Adam Summerfield and Parina Patel. All four received a well-deserved Distinction in their Masters course. We wish them all the best for the future. More...

Published: Sep 19, 2014 3:20:37 PM

PLoS One paper for Dr Cathy Slack

25 October 2012

Congratulations to Dr Cathy Slack (Partridge Laboratory) on the publication of her paper 'Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin is insufficient to Extend Lifespan in Drosophila' in PLoS One.

Abstract -
The biguanide drug, metformin, commonly used to treat type-2 diabetes, has been shown to extend lifespan and reduce fecundity in C. elegans through a dietary restriction-like mechanism via the AMP-activated protein kinase (AMPK) and the AMPK-activating kinase, LKB1. We have investigated whether the longevity-promoting effects of metformin are evolutionarily conserved using the fruit fly, Drosophila melanogaster. We show here that while feeding metformin to adult Drosophila resulted in a robust activation of AMPK and reduced lipid stores, it did not increase lifespan in either male or female flies. In fact, we found that when administered at high concentrations, metformin is toxic to flies. Furthermore, no decreases in female fecundity were observed except at the most toxic dose. Analysis of intestinal physiology after metformin treatment suggests that these deleterious effects may result from disruptions to intestinal fluid homeostasis. Thus, metformin appears to have evolutionarily conserved effects on metabolism but not on fecundity or lifespan.

Page last modified on 25 oct 12 15:26