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David Gems on BBC Radio 4 "Archive on 4"

On Saturday, November 26 2016 BBC Radio 4 broadcast a 1 hr programme entitled "Logan's Run and Intergenerational War", presented by Ed Howker, with extensive contributions from IHA Co-Director Professor David Gems. The programme included in depth discussion of the impact of the ageing of populations, and the prospects for treatments for ageing to improve late-life health. Among other contributors to the programme were former Universities and Science minister David Willetts and the actress Jenny Agutter.

The programme is available for a short period via the BBC iPlayer at http://www.bbc.co.uk/programmes/b083j672#play
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Published: Nov 30, 2016 12:53:17 PM

UCL Ageing Event blog post

Members of the IHA including Dr Nazif Alic and Dr Jenny Regan recently helped organise and participate in the highly successful UCL Ageing Event. This was the second Ageing Event and was targetted at post-doctoral researchers working in the ageing field across UCL. Emma Chambers, Research Associate in the Division of Infection and Immunity, has written a blog about the event.
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Published: Nov 18, 2016 2:53:13 PM

CNN news: How long can humans live?

Following her BBC interview Professor Linda Partridge spoke with CNN's Bianca Britton, whose article asks, "how long can humans live?" More...

Published: Oct 6, 2016 3:07:38 PM

PLoS One paper for Dr Cathy Slack

25 October 2012

Congratulations to Dr Cathy Slack (Partridge Laboratory) on the publication of her paper 'Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin is insufficient to Extend Lifespan in Drosophila' in PLoS One.

Abstract -
The biguanide drug, metformin, commonly used to treat type-2 diabetes, has been shown to extend lifespan and reduce fecundity in C. elegans through a dietary restriction-like mechanism via the AMP-activated protein kinase (AMPK) and the AMPK-activating kinase, LKB1. We have investigated whether the longevity-promoting effects of metformin are evolutionarily conserved using the fruit fly, Drosophila melanogaster. We show here that while feeding metformin to adult Drosophila resulted in a robust activation of AMPK and reduced lipid stores, it did not increase lifespan in either male or female flies. In fact, we found that when administered at high concentrations, metformin is toxic to flies. Furthermore, no decreases in female fecundity were observed except at the most toxic dose. Analysis of intestinal physiology after metformin treatment suggests that these deleterious effects may result from disruptions to intestinal fluid homeostasis. Thus, metformin appears to have evolutionarily conserved effects on metabolism but not on fecundity or lifespan.

Page last modified on 25 oct 12 15:26