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Congratulations to Dr Adam Dobson on his paper in Cell Reports

Congratulatsions to Adam Dobson and Nazif Alic whose paper, "Nutritional Programming of Lifespan by FOXO Inhibition on Sugar-Rich Diets," has just been published in Cell Reports. Their study shows that a history of feeding on a high sugar-diet shortens lifespan and changes gene expression. These changes appear to be mediated by FoxO/Daf16 in both flies and worms More...

Published: Jan 11, 2017 10:42:21 AM

Welcome to Matías Fuentealba

The IHA extends a warm welcome to Matías Fuentealba who joins Linda Partridge’s group this week as a PhD student. Matias recently completed his Masters in Biological Sciences at the Universidad de Chile, where his work comprised a “study of the energetics and structural characteristics of NAD and NADP binding sites through statistical potentials.” Welcome to London Matías!
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Published: Jan 10, 2017 11:44:35 AM

David Gems on BBC Radio 4 "Archive on 4"

On Saturday, November 26 2016 BBC Radio 4 broadcast a 1 hr programme entitled "Logan's Run and Intergenerational War", presented by Ed Howker, with extensive contributions from IHA Co-Director Professor David Gems. The programme included in depth discussion of the impact of the ageing of populations, and the prospects for treatments for ageing to improve late-life health. Among other contributors to the programme were former Universities and Science minister David Willetts and the actress Jenny Agutter.

The programme is available for a short period via the BBC iPlayer at http://www.bbc.co.uk/programmes/b083j672#play
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Published: Nov 30, 2016 12:53:17 PM

PLoS One paper for Dr Cathy Slack

25 October 2012

Congratulations to Dr Cathy Slack (Partridge Laboratory) on the publication of her paper 'Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin is insufficient to Extend Lifespan in Drosophila' in PLoS One.

Abstract -
The biguanide drug, metformin, commonly used to treat type-2 diabetes, has been shown to extend lifespan and reduce fecundity in C. elegans through a dietary restriction-like mechanism via the AMP-activated protein kinase (AMPK) and the AMPK-activating kinase, LKB1. We have investigated whether the longevity-promoting effects of metformin are evolutionarily conserved using the fruit fly, Drosophila melanogaster. We show here that while feeding metformin to adult Drosophila resulted in a robust activation of AMPK and reduced lipid stores, it did not increase lifespan in either male or female flies. In fact, we found that when administered at high concentrations, metformin is toxic to flies. Furthermore, no decreases in female fecundity were observed except at the most toxic dose. Analysis of intestinal physiology after metformin treatment suggests that these deleterious effects may result from disruptions to intestinal fluid homeostasis. Thus, metformin appears to have evolutionarily conserved effects on metabolism but not on fecundity or lifespan.

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