- Nazif Alic
- A Scholar's Life for me
- A Visit from Glenlola Collegiate School
- Arne Akbar
- Nature Paper published
- Changing of the Guard in C. elegans lab
- Holiday School Visit
- Congratulations to Li Li
- Thanks from Nature...
- Gordon Research Conference 2012
- Darwin's Birthday Party 2012
- Congratulations Tosin ...
- Well Done Sahar!
- Royal Society Summer Science Exhibition 2012
- Cheltenham Science Festival 2012
- Congratulations to Dr Matt Piper ...
- Ekin Bolukbasi - Chicago Conference
- Matt Piper - Lisbon
- Helena Cocheme - Nature Protocols paper
- Congratulations to Dr Daniel Pearce ...
- David Gems - Moscow conference
- Jorge Ivan Castillo-Quan
- IHA - success for our students
- RS SSE 2012 - 'Why Fly?'
- Congratulations to Sahar Emran ...
- Fiona Kerr - Alzheimer's Association International Conference highlights
- New WT Senior Research Fellow post in the IHA
- IHA at the Royal Society Summer Science Exhibition 2012
- Congratulations to Professor David Gems
- A bientot Matt and Bill
- Hearing impaired students visit the IHA
- Healthy Ageing exhibition news
- Congratulations to Dr Ivana Bjedov
- New WTSA for the IHA!!
- New roles for the Partridge and Gems labs
- PLoS One paper for Dr Cathy Slack
- 3 year Bioinformatics PhD studentship now available
- Congratulations to Dr Nuria Vergara
- Welcome to Michael Wright ...
- Sahar Emran awarded bursary by Biochemical Society
- MRes in Biology of Ageing and Age-related disease
- Watch Dr Matt Piper's Lunchtime Lecture
- Explore Ageing Research with Dr Matt Piper at the Royal Society Café Scientifique
- Wellcome Trust Packed Lunch Podcast with Dr Matt Piper
- Watch the IHA Harlem Shake!
- Gems Lab News Winter Roundup
- Dr Jennifer Regan: Immunity, Ageing and Gender – Why is Life Deadlier for the Male? March 22nd
- Congratulations to Tosin Taiwo
- Carolina Soto Palma to attend The Times Cheltenham Science Festival
- Giovanna Vinti awarded UCL Green Impact Award
- IHA Race for Life teams kicks off with Bake Sale
The ladies of the IHA who this year will be participating in Cancer Research UK's 'Race for Life' successfully held a bake sale on Wednesday and raised an impressive £290 towards their total goal! A huge variety of delicious cakes, generously baked by the team and their friends from the IHA, were snapped up by hungry staff and students alike. Thanks team and well done! If you would like to make a donation to this worthy cause please visit the team's JustGiving page at: http://www.raceforlifesponsorme.org More...
Published: May 10, 2013 10:26:26 AM
We are delighted to announce that the 'Green-Darwin' Green Impact Team has won two Bronze Awards which were presented by the Provost at an Awards Ceremony held last week. The IHA's Giovanna Vinti secured the first award for 'Green-Darwin Labs' and the 'Green Darwin' team won a second.
These fantastic achievements form part of the efforts of the wider UCL community in pressing forward the green agenda. Awards went to teams across UCL for work that included putting up awareness-raising notices and posters encouraging people to switch off lights and equipment when not needed, potentially saving 7,038kg CO2 per year; and likewise to print and photocopy double-sided, potentially saving 108,594kg CO2 and £40,220 on resource costs this year across the institution. More...
Published: Apr 30, 2013 10:37:33 AM
Congratulations to Carolina Soto Palma, an MRes student under the supervision of Dr. Gene Schuster, who has been awarded one of only ten UCL Graduate School bursaries to attend The Times Cheltenham Science Festival. More...
Published: Apr 24, 2013 3:37:38 PM
PLoS One paper for Dr Cathy Slack
25 October 2012
Congratulations to Dr Cathy Slack (Partridge Laboratory) on the publication of her paper 'Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin is insufficient to Extend Lifespan in Drosophila' in PLoS One.
The biguanide drug, metformin, commonly used to treat type-2 diabetes, has been shown to extend lifespan and reduce fecundity in C. elegans through a dietary restriction-like mechanism via the AMP-activated protein kinase (AMPK) and the AMPK-activating kinase, LKB1. We have investigated whether the longevity-promoting effects of metformin are evolutionarily conserved using the fruit fly, Drosophila melanogaster. We show here that while feeding metformin to adult Drosophila resulted in a robust activation of AMPK and reduced lipid stores, it did not increase lifespan in either male or female flies. In fact, we found that when administered at high concentrations, metformin is toxic to flies. Furthermore, no decreases in female fecundity were observed except at the most toxic dose. Analysis of intestinal physiology after metformin treatment suggests that these deleterious effects may result from disruptions to intestinal fluid homeostasis. Thus, metformin appears to have evolutionarily conserved effects on metabolism but not on fecundity or lifespan.
Page last modified on 25 oct 12 15:26