Institute of Healthy Ageing


Congratulations to Ekin Bolukbasi on her Cell Reports paper

19 October 2017

The paper identifies the transcription factor FKH as a mediator of nutrient-sensing pathway signaling in Drosophila, and characterizes FKH’s essential involvement in increased longevity via this network. The authors pinpoint FKH’s pro-longevity effect to the gut, and they show increased expression of nutrient transporters and improvement of barrier function by FKH activity. Malnutrition caused by poor intestinal absorption is a major problem in the elderly, and a better understanding of the mechanisms involved will have important therapeutic implications for human aging.