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Congratulations to Dr Teresa Niccoli on her paper in Current Biology

Congratulations to Dr Teresa Niccoli whose paper "Increased Glucose Transport into Neurons Rescues Ab Toxicity in Drosophila" has just been published in Current Biology by Cell Press. More...

Published: Aug 17, 2016 3:05:35 PM

ARUK funded post-doc position available at the IHA

The Institute of Healthy Ageing is currently seeking a post-doctoral research associate to work on the following ARUK-funded project.

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating, mid-life, neurodegenerative disorders for which no cure is currently available. Large expansions of a hexanucleotide GGGGCC-repeat in the first intron of the C9orf72 gene is the most common genetic cause of both ALS and FTD. We recently developed novel Drosophila models of C9orf72 repeat-induced neurodegeneration (Mizielinska et al Science 2014, 345:1192-1194).

This 3-year post-doctoral position will build on this work by investigating disease mechanisms in a range of C9orf72 fly lines using several approaches including genome-wide transcriptomic and translational analyses in both flies and iPSC-neurons. You will work as part of a collaborative team of investigators in the excellent and supportive scientific research community of UCL.

The post is funded for 3 years in the first instance by Alzheimer’s Research UK and is available from October 2016.

For full information and to apply please visit the UCL website at https://goo.gl/E5vk8j
More...

Published: Aug 11, 2016 2:27:25 PM

Lectureship for Alexandre Benedetto

Until recently an EU-funded postdoc in David Gems's lab, Alex Benedetto will shortly set up his own laboratory at the University of Lancaster, in the Department of Biomedical and Life Sciences. There he will continue his investigations of the biology of ageing in model organisms, particularly C. elegans. We wish Alex all the best in setting up his new lab! More...

Published: Jul 20, 2016 2:10:01 PM

Arne Akbar

3 April 2012

20 September 2011


A study led by Professor Arne Akbar, Associate of the IHA, was published today.  The work focussed on ways to revitalise white blood cells that were thought to have been deactivated after fighting infections.

Previous research had suggested that white blood cells had a finite lifespan, meaning they gave less protection as a person aged.  This was thought to be determined by 'caps' on the end of DNA called telomeres which get shorter as the body fights infection.  Prof Akbar's team showed however that some white cells were inactive yet had long telomeres, suggesting another mechanism in the immune system was switching them off.  When they blocked off the newly identified pathway, they found that the white blood cells appeared to 'come to life' again.

For more on this story, see the following links:

Press coverage
Journal of Immunology
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