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Linda Partridge and the IHA feature interview with Time Out London

Professor Linda Partridge was recently interviewed by Time Out London and features in today's issue ('Rad Scientists', Time Out, 20/09/2016). You can read the article via our Facebook site at https://www.facebook.com/UCLInstituteofHealthyAgeing/
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Published: Sep 20, 2016 11:43:25 AM

Congratulations to Dr Teresa Niccoli on her paper in Current Biology

Congratulations to Dr Teresa Niccoli whose paper "Increased Glucose Transport into Neurons Rescues Ab Toxicity in Drosophila" has just been published in Current Biology by Cell Press. More...

Published: Aug 17, 2016 3:05:35 PM

ARUK funded post-doc position available at the IHA

The Institute of Healthy Ageing is currently seeking a post-doctoral research associate to work on the following ARUK-funded project.

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating, mid-life, neurodegenerative disorders for which no cure is currently available. Large expansions of a hexanucleotide GGGGCC-repeat in the first intron of the C9orf72 gene is the most common genetic cause of both ALS and FTD. We recently developed novel Drosophila models of C9orf72 repeat-induced neurodegeneration (Mizielinska et al Science 2014, 345:1192-1194).

This 3-year post-doctoral position will build on this work by investigating disease mechanisms in a range of C9orf72 fly lines using several approaches including genome-wide transcriptomic and translational analyses in both flies and iPSC-neurons. You will work as part of a collaborative team of investigators in the excellent and supportive scientific research community of UCL.

The post is funded for 3 years in the first instance by Alzheimer’s Research UK and is available from October 2016.

For full information and to apply please visit the UCL website at https://goo.gl/E5vk8j
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Published: Aug 11, 2016 2:27:25 PM

IHA news

Linda Partridge and the IHA feature interview with Time Out London

Publication date:

Professor Linda Partridge was recently interviewed by Time Out London and features in today's issue ('Rad Scientists', Time Out, 20/09/2016). You can read the article via our Facebook site at https://www.facebook.com/UCLInstituteofHealthyAgeing/

Congratulations to Dr Teresa Niccoli on her paper in Current Biology

Publication date:

Congratulations to Dr Teresa Niccoli whose paper "Increased Glucose Transport into Neurons Rescues Ab Toxicity in Drosophila" has just been published in Current Biology by Cell Press.

ARUK funded post-doc position available at the IHA

Publication date:

The Institute of Healthy Ageing is currently seeking a post-doctoral research associate to work on the following ARUK-funded project.

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating, mid-life, neurodegenerative disorders for which no cure is currently available. Large expansions of a hexanucleotide GGGGCC-repeat in the first intron of the C9orf72 gene is the most common genetic cause of both ALS and FTD. We recently developed novel Drosophila models of C9orf72 repeat-induced neurodegeneration (Mizielinska et al Science 2014, 345:1192-1194).

This 3-year post-doctoral position will build on this work by investigating disease mechanisms in a range of C9orf72 fly lines using several approaches including genome-wide transcriptomic and translational analyses in both flies and iPSC-neurons. You will work as part of a collaborative team of investigators in the excellent and supportive scientific research community of UCL.

The post is funded for 3 years in the first instance by Alzheimer’s Research UK and is available from October 2016.

For full information and to apply please visit the UCL website at https://goo.gl/E5vk8j

Lectureship for Alexandre Benedetto

Publication date:

Until recently an EU-funded postdoc in David Gems's lab, Alex Benedetto will shortly set up his own laboratory at the University of Lancaster, in the Department of Biomedical and Life Sciences. There he will continue his investigations of the biology of ageing in model organisms, particularly C. elegans. We wish Alex all the best in setting up his new lab!

Congratulations to Yila de la Guardia

Publication date:

New report on the origins of age-related disease in C. elegans

Congratulations to Yila de la Guardia whose report on the mechanisms underlying a major form of age-related pathology in C. elegans was published recently ('Run-on of germline apoptosis promotes gonad senescence in C. elegans.' Oncotarget 2016 May 31. doi: 10.18632/oncotarget.9681. [Epub ahead of print]).

Congratulations to Dr Jorge Ivan Castillo Quan on his Cell Reports paper

Publication date:

Congratulations to Dr Jorge Ivan Castillo Quan whose paper in Cell Reports was published today. His research, which was carried out during his PhD studies at the Institute of Healthy Ageing, demonstrates that fruit flies live 16% longer than average when given low doses of the mood stabiliser lithium.

Dr Jennifer Regan's paper on sex difference in ageing gut pathology published in eLIFE

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Congratulation to the IHA's Dr Jennifer Regan whose paper on sex difference in the pathology of ageing gut has just been published in the eLIFE journal.

Memory Matters at the British Library

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A group of research staff and students from the IHA (Fiona Kerr, Teresa Niccoli, Nathan Woodling, Oyinkansola Adesaki, Jorge Quan Castillo, Thomas Moens, Rubika Balendra) recently appeared as part of the British Library's sold-out Memory Matters event on Friday, October 30th.

Jorge Ivan Castillo Quan on Anti-Ageing research

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'Anti-Ageing: Health or Beauty?' A guest blog by Jorge Ivan Castillo Quan, written for the 2015 Write About Research Competition.

http://blogs.ucl.ac.uk/…/2…/07/07/anti-ageing-health-beauty/

Talks from Gems Lab at International C. elegans Meeting

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Dr Marina Ezcurra and Dr Alex Benedetto were both selected to speak at the recent International C. elegans Meeting in Los Angeles (June 24th-28th). The two talks described new breakthroughs in understanding the mechanisms by which age-related pathologies originate in C. elegans, and generated considerable interest. Alex also described a new stress-resistance assay based on death fluorescence, recently discovered in the Gems lab. For details of the C. elegans International Meeting see http://www.genetics-gsa.org/celegans/2015/

Institute of Healthy Ageing hosts BSRA Annual Meeting

Publication date:

The 65th British Society for Research on Ageing Annual Meeting took place at the Institute of Healthy Ageing on July 1st-2nd 2015. Speakers at the conference included Claudio Franceschi (Bologna), Paul Shiels (Glasgow), Jesus Gil (Imperial), and Avan Aihie Sayer (Southampton). They also included several speakers from the IHA: Lazaros Foukas, who described how ageing can be slowed down in mice by reducing PI3 kinase signalling, Cathy Slack (whose talk was awarded the Korenchevsky Prize) spoke about how Ras signalling controls fruitfly ageing, and David Gems who gave a welcome address, including a discussion of “The ageing-disease false dichotomy”.
For further information about the meeting see http://www.bsra.org.uk/node/842

New article by David Gems!

Publication date:

A new article has just been published in the journal Frontiers in Genetics, entitled “The aging-disease false dichotomy: understanding senescence as pathology” (June 16, 2015, vol. 6, article 212). The article describes how a number of current worries about the prospects of treatments for ageing are misconceptions generated the traditional but incorrect view that ageing is distinct from age-related disease. It also proposes a new understanding of how interventions that extend lifespan operate that reconciles opposing views of traditional medicine and biogerontology. See http://journal.frontiersin.org/article/10.3389/fgene.2015.00212/abstract

Cell paper reveals how a cancer drug makes fruit flies live longer

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A paper by researchers from the IHA Dr Cathy Slack and Dr Nazif Alic demonstrate new targets for drugs against ageing. Their research published in Cell shows how inhibition of the Ras-Erk-ETS pathway extends fly lifespan.
http://www.cell.com/cell/abstract/S0092-8674%2815%2900707-2

Dr Jorge Ivan Castillo Quan - Anti-Aging: Beauty or Health?

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Watch the IHA's Dr Jorge Ivan Castillo Quan's talk on Anti-Aging. His fascinating talk was part of a very successful event called TEDx held at Goodenough College.

Brain paper published by Partridge Lab

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Research staff from the IHA's Partridge Lab, including Dr Jorge Ivan Castillo Quan and PhD student Ms Li Li, are among those whose work has recently been published in Brain. Their paper is entitled, "Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction".

Help support the IHA Race for Life team!

Publication date:

An IHA team led by lab technician Melissa Cabecinha will be running 5km around Regent's Park on Saturday, May 30th as part of CRUK's Race for Life challenge.

If you would like to support our team by making a donation please visit Melissa's fundraising page at: https://www.justgiving.com/iha-ladies

Thank you!

Wellcome Trust Conference - Healthy Ageing: From Molecules to Organisms

Publication date:

IHA Director Professor Linda Partridge is one of the organisers of the new Wellcome Trust Conference on Healthy Ageing being held 18-20 May 2015.
https://registration.hinxton.wellcome.ac.uk/display_info.asp?id=467

Ageing can lead to declining health and function, and it is the major risk factor for cancer, neurodegenerative and cardiovascular disease. This new Wellcome Trust conference will focus on recent discoveries and current challenges in ageing research, with a focus on translating basic research insights into health improvement for older people. We aim to explore the mechanisms of ageing in cells, tissues and organisms in order to identify interventions that can ameliorate its negative effects. The meeting will also emphasise the connection between discoveries made in model organisms and mechanisms leading to healthy ageing in humans.

The meeting is aimed at scientists, clinicians and drug developers involved in research into ageing and other relevant fields. We welcome the submission of abstracts from all areas relevant to the main themes of the meeting. Several oral presentations will be chosen from the abstracts submitted.

Topics will include: Human ageing Stem cells and cellular senescence, Physiology of homeostasis, Nutrition and metabolism, Genome stability, Epigenetics, Systems biology, Drug developmen.

Dr Nazif Alic paper published in Royal Society Proceedings B

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Congratulations to Dr Nazif Alic whose paper has been published in the Royal Society's flagship biological research journal Proceedings B.

Linda Partridge to speak at Nobel Week Dialogue, Live streaming and Q&A

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Join in the digital discussion on ageing with IHA Director Linda Partridge as part of this year's Nobel Week Dialogue on 9th December. 

IHA Director Prof Linda Partridge honoured with BBSRC Excellence Award

Publication date:

IHA Director, Professor Linda Partridge, has been recognised with a BBSRC Anniversary Award for Excellence in Bioscience.

The Biotechnology and Biological Sciences Research Council (BBSRC) has recognised outstanding contributions to bioscience made by four of its research community. As part of BBSRC’s 20th anniversary, the awards demonstrate pride for the UK's world-leading bioscience research base and the impact it has achieved in the last two decades.

The awards will be presented at the Great British Bioscience Festival in November.

Professor Jackie Hunter, BBSRC Chief Executive, said: "Our 20th anniversary year is the perfect time to acknowledge and celebrate the achievements of researchers that BBSRC has supported. These awards highlight outstanding achievements that benefit us all and help to make the UK world-leading in bioscience."

Congratulations Linda!

Dr Nazif Alic on the The Naked Scientists

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Nazif Alic talks about healthspan and healthy ageing on The Naked Scientists.

Former IHA students start PhD's at Cambridge University

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The IHA is pleased to announce that former students Michael Shannack and Nattaphong Rattanavirotkul will both be starting PhD courses at Cambridge University this year. We wish them the best of luck in their studies!

IHA MRes students to receive Distinctions in their degrees!

Publication date:

Congratulations to IHA MRes students Michael Shannack, Nattaphong Rattanavirotkul, Adam Summerfield and Parina Patel. All four received a well-deserved Distinction in their Masters course. We wish them all the best for the future.

Dr Nazif Alic paper published in PLOS Genetics

Publication date:

In their recent paper in PLOS Genetics Alic and co-workers explore the complex relationship between Drosophila foxo, a transcription factor with evolutionarily conserved role in ageing, and Anterior open, an ETS-family transcription factor that is a direct target of dFOXO in the adult gut and whose activation can extend lifespan.

The paper is entitled, "Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster"

View the article here: http://tinyurl.com/off4cqq

Gems Lab Summer Roundup

Publication date:

Congratulations to Jennifer Tullet (again!)

In September, Dr Jennifer Tullet will cease to be a postdoc, and take up
a Principle Investigator position running her own lab at the University
of Kent, where she will continue her investigations of ageing in C.
elegans. Jennifer also recently spoke at the American Aging Association
meeting in San Antonio, Texas, and recently published a paper entitled
“DAF-16 target identification in C. elegans: past, present and future”
in the journal Biogerontology.

Congratulations to Dr Yila de la Guardia!

Yila de la Guardia recently passed her Ph.D. viva (examiners, Prof Bart
Braeckman from the University of Ghent, and Dr Lazaros Foukas from the
IHA). Yila has now returned to Panama, and she is much missed.

New members of the lab

The lab welcomes three new members! Dr Yuan Zhao moved to the lab from
Cancer Research UK, London, where she worked on telomeres in fission
yeast with Dr Julie Cooper; and Dr Evgeniy Galimov from the National
Research Centre for Preventive Medicine, Moscow, where he worked on ROS
signalling and p66shc with Prof Viktor Skulachev. Both positions are
funded by the Wellcome Trust. Welcome also to Thanet Sornda who recently
started Ph.D. research in the lab. Thanet previously did a Master’s
degree at the Institute of Ageing and Health, Newcastle University, and
is funded by the state of Thailand.

News about David Gems

David gave various talks, e.g. at the Genetics of Aging and Longevity
meeting in Sochi (April), Russia, the British Society for Research on
Ageing meeting in Liverpool (July), and at Oxford and Cambridge
universities. He recently published two essays: 'What is an anti-aging
treatment?' Exp. Gerontol. (2014) 58: 14-18; and 'Evolution of sexually
dimorphic longevity in humans.' Aging (2014) 6: 84-91.

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