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Research Technician post available

We are seeking a technician to work on a project investigating genetic modifiers of a fly model of frontotemporal dementia and amyotrophic lateral sclerosis (caused by C9orf72 mutation) in Professor Linda Partridge’s laboratory and Drosophila fly facility. The post will involve data gathering and monitoring, in addition to setting up and carefully maintaining transgenic fly stocks. The post is available in the first instance until September 2018. For full details and to apply please visit https://atsv7.wcn.co.uk/search_engine/jobs.cgi?SID=amNvZGU9MTYzODcxMiZ2dF90ZW1wbGF0ZT05NjUmb3duZXI9NTA0MTE3OCZvd25lcnR5cGU9ZmFpciZicmFuZF9pZD0wJnZhY3R5cGU9MTI3NyZwb3N0aW5nX2NvZGU9MjI0

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Welcome to Magda Atilano

 Welcome to Dr Magda Atilano who joins the Partridge lab at the IHA today. Magda is joining us from the Biochemistry department at University of Oxford where she worked in Drosophila immunity lab.

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Welcome to Matías Fuentealba

The IHA extends a warm welcome to Matías Fuentealba who joins Linda Partridge’s group this week as a PhD student. Matias recently completed his Masters in Biological Sciences at the Universidad de Chile, where his work comprised a “study of the energetics and structural characteristics of NAD and NADP binding sites through statistical potentials.” Welcome to London Matías!

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David Gems on BBC Radio 4 "Archive on 4"

On Saturday, November 26 2016 BBC Radio 4 broadcast a 1 hr programme entitled "Logan's Run and Intergenerational War", presented by Ed Howker, with extensive contributions from IHA Co-Director Professor David Gems. The programme included in depth discussion of the impact of the ageing of populations, and the prospects for treatments for ageing to improve late-life health. Among other contributors to the programme were former Universities and Science minister David Willetts and the actress Jenny Agutter.

The programme is available for a short period via the BBC iPlayer at http://www.bbc.co.uk/programmes/b083j672#play

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CNN news: How long can humans live?

Following her BBC interview Professor Linda Partridge spoke with CNN's Bianca Britton, whose article asks, "how long can humans live?"

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ARUK funded post-doc position available at the IHA

The Institute of Healthy Ageing is currently seeking a post-doctoral research associate to work on the following ARUK-funded project.

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating, mid-life, neurodegenerative disorders for which no cure is currently available. Large expansions of a hexanucleotide GGGGCC-repeat in the first intron of the C9orf72 gene is the most common genetic cause of both ALS and FTD. We recently developed novel Drosophila models of C9orf72 repeat-induced neurodegeneration (Mizielinska et al Science 2014, 345:1192-1194).

This 3-year post-doctoral position will build on this work by investigating disease mechanisms in a range of C9orf72 fly lines using several approaches including genome-wide transcriptomic and translational analyses in both flies and iPSC-neurons. You will work as part of a collaborative team of investigators in the excellent and supportive scientific research community of UCL.

The post is funded for 3 years in the first instance by Alzheimer’s Research UK and is available from October 2016.

For full information and to apply please visit the UCL website at https://goo.gl/E5vk8j

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Lectureship for Alexandre Benedetto

Until recently an EU-funded postdoc in David Gems's lab, Alex Benedetto will shortly set up his own laboratory at the University of Lancaster, in the Department of Biomedical and Life Sciences. There he will continue his investigations of the biology of ageing in model organisms, particularly C. elegans. We wish Alex all the best in setting up his new lab!

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Congratulations to Dr Jorge Ivan Castillo Quan on his Cell Reports paper

Congratulations to Dr Jorge Ivan Castillo Quan whose paper in Cell Reports was published today. His research, which was carried out during his PhD studies at the Institute of Healthy Ageing, demonstrates that fruit flies live 16% longer than average when given low doses of the mood stabiliser lithium.

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Memory Matters at the British Library

A group of research staff and students from the IHA (Fiona Kerr, Teresa Niccoli, Nathan Woodling, Oyinkansola Adesaki, Jorge Quan Castillo, Thomas Moens, Rubika Balendra) recently appeared as part of the British Library's sold-out Memory Matters event on Friday, October 30th.

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Talks from Gems Lab at International C. elegans Meeting

Dr Marina Ezcurra and Dr Alex Benedetto were both selected to speak at the recent International C. elegans Meeting in Los Angeles (June 24th-28th). The two talks described new breakthroughs in understanding the mechanisms by which age-related pathologies originate in C. elegans, and generated considerable interest. Alex also described a new stress-resistance assay based on death fluorescence, recently discovered in the Gems lab. For details of the C. elegans International Meeting see http://www.genetics-gsa.org/celegans/2015/

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Institute of Healthy Ageing hosts BSRA Annual Meeting

The 65th British Society for Research on Ageing Annual Meeting took place at the Institute of Healthy Ageing on July 1st-2nd 2015. Speakers at the conference included Claudio Franceschi (Bologna), Paul Shiels (Glasgow), Jesus Gil (Imperial), and Avan Aihie Sayer (Southampton). They also included several speakers from the IHA: Lazaros Foukas, who described how ageing can be slowed down in mice by reducing PI3 kinase signalling, Cathy Slack (whose talk was awarded the Korenchevsky Prize) spoke about how Ras signalling controls fruitfly ageing, and David Gems who gave a welcome address, including a discussion of “The ageing-disease false dichotomy”.
For further information about the meeting see http://www.bsra.org.uk/node/842

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New article by David Gems!

A new article has just been published in the journal Frontiers in Genetics, entitled “The aging-disease false dichotomy: understanding senescence as pathology” (June 16, 2015, vol. 6, article 212). The article describes how a number of current worries about the prospects of treatments for ageing are misconceptions generated the traditional but incorrect view that ageing is distinct from age-related disease. It also proposes a new understanding of how interventions that extend lifespan operate that reconciles opposing views of traditional medicine and biogerontology. See http://journal.frontiersin.org/article/10.3389/fgene.2015.00212/abstract

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