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Biological mass spectrometry centre
Electrospray Quadrupole- Time of Flight Mass Spectrometry (ESI-QTOF)
The Centre has the ability to perform metabolomic comparative studies of complex solutions (plasma, urine etc.) to detect changes in metabolite concentrations using an ESI QTOF MS coupled to a HPLC (Waters 2795 XE). All data is analysed and compared using MarkerLynx processing software.
Gas Chromatography-mass spectrometry (GC-MS)
There are three Hewlett Packard / Agilent GC-MS mass spectrometers
situated within the unit. GC-MS is typically used to quantitate
and identify primarily non-polar metabolites, sugars, fatty
drugs of abuse, steroids, cholesterol metabolites etc which are
than 1 kDa in mass.
More on gas chromatography mass spectrometry including animated diagram...
High Performance Liquid Chromatography electrospray tandem mass spectrometry (HPLC-ESI-MS/MS)
The unit has a QuattroMicro triple quadrupole mass spectrometer
to a Waters 2795 XE HPLC instrument. HPLC-MS/MS is used for the
identification and quantitation of polar metabolites less than 2
It is a particularly powerful technique as it can be used to
measure specific metabolites in mixtures without the need for
More on High Performance Liquid Chromatography electrospray tandem mass spectrometry...
Page last modified on 07 jun 10 09:42