GOSomics - What we do

Biomarker Discovery

• Experiment design, including sample selection

• Proteomics analysis of samples for differential protein expression

• Evaluation of preliminary raw data including bioinformatics

Translation of Biomarkers to Laboratory Based Tests

• Validation of biomarkers

• Development of protein markers into mass spectrometry based tests

Our expertise include:

•  2D Difference Gel Electrophoresis (2D DiGE) and 2D PAGE

  Label Free Quantitation

  • Used for overall screening of differential protein expression
  • Or can be used for identification of complex protein mixtures such as Co-IP or bead based protein-protein interactions

•   The development of peptide based Multiple Reaction Monitoring (MRM) LC-MS assays

GOSomics is a new facility, funded by the National Institute for Health Research (NIHR) through Great Ormond Street Hospital Biomedical Research Centre (GOSH BRC). We are part of the new 2012 BRC Diagnostics and Imaging theme lead by Professor Neil Sebire and are based within the ICH Biological Mass Spectrometry facility run by Dr Kevin Mills.

Page last modified on 19 sep 12 18:10