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UCL Great Ormond Street Institute of Child Health

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Prof Stephen Hart

Prof Stephen Hart

Contacts

Address

UCL Institute of Child Health
30 Guilford Street
London
WC1N 1EH

Appointments

  • Professor in Molcular Genetics
    ICH Genetics & Genomic Medicine Prog
    UCL GOS Institute of Child Health

Joined UCL

1994-10-01

Gene therapy offers exciting opportunities for the development oftherapies in virtually all areas of medicine. Recent clinical advances arestarting to realise this potential although there remain many challenges amongst which delivery is a key issue. Much of my research has thereforefocused on this challenging area to develop delivery methods compatible withclinical use. In particular I have developed a family of synthetic gene delivery formulations, or nanoparticles, from conceptual stages through to treatment of disease models in vivo.  More recently we have extended our formulations to the delivery of siRNA and other oligonucleotides as well as imaging contrast agents and radiolabels for real-time imaging of delivery in vivo.

 I have established a number of collaborations, exploiting the breadth of high quality research groups at UCL, including Departments of Chemistry, Biochemical Engineering, Centre for Respiratory Medicine, and the Centre for Cardiovascular Biology and Medicine. These collaborations have led to highly productive interdisciplinary hypothesis-driven research, involving synthesis ofnovel reagents, studies to establish the fundamental rules and relationshipsconcerning vector structure and function and correction of animal models ofdisease.

Overall the research areas are non-viral vector development and gene therapy for: 1) gene therapy for cardiovascular diseases (bypass grafts), 2) gene therapy for respiratory diseases (cystic fibrosis), 3) gene therapy for cancer (neuroblastoma), 4) gene therapy for the brain, 5) further vector development.

Award year Qualification Institution
1991 PhD
Doctor of Philosophy
Molecular Microbiology
University of Cape Town
1986 MSc
Master of Science
Human Genetics
University of the Witwatersrand
1981 BSc Hons
Bachelor of Science (Honours)
Genetics
University of Liverpool


Keywords

Alzheimer's disease|*|Atherosclerosis|*|Brain|*|Brain imaging|*|Cancer|*|Cardiovascular|*|Child health|*|Clinical trials|*|Cystic fibrosis|*|DNA vaccines|*|Dementia|*|Gene and cell-based therapies|*|Gene expression|*|Gene therapy|*|Genetics|*|Glioblastoma|*|Imaging|*|Infection|*|Inflammation|*|Liposome formulation|*|Liposomes|*|Luminometry|*|MRI|*|MRNA|*|Nanoparticles|*|Nanotechnology|*|Nebulisation|*|Neointimal hyperplasia|*|Neuroblastoma|*|Neurodegeneration|*|Nitric oxide|*|Non-viral vectors|*|Peptides|*|QPCR|*|RNAi|*|SiRNA|*|Stem cells|*|Transfection

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