UCL Great Ormond Street Institute of Child Health


Prof Chris Clark

Prof Chris Clark


Institute of Child Health UCL
30 Guildford Street


  • Professor of Imaging and Biophysics
    ICH Developmental Neurosciences Prog
    UCL GOS Institute of Child Health

Joined UCL


My research focus is on the development and application of diffusion tensor imaging (DTI) and tractography for the understanding of neurological disability. Tractography uniquely allows the mapping of the white matter tracts of the living human brain. These methods can be used to reconstruct a wide range of clinically eloquent tracts such as the cortico-spinal tracts, fornix, optic radiations and uncinate fasciculus among others. A particular theme of research in which I have been active is the development of these methods for the purposes of neurosurgical planning in both children and adults. I am also using these methods to investigate the relationship between white matter damage and post-surgical deficits. I am leading a number of research projects both on the development of tractography methods, using for example Markov Chain Monte Carlo methods, as well as a wide range of clinical studies in children focused on epilepsy (temporal lobe epilepsy, febrile convulsions, infantile spasm) and brain tumour diagnosis and collaborate with colleagues on studies in developmental amnesia. I am also actively participating in adult studies of stroke recovery and early white matter damage in familial Alzheimer’s disease.
Award year Qualification Institution
1998 PhD
Doctor of Philosophy
Medical Imaging
University College London
1994 MSc
Master of Science
Radiation Physics
University College London
1990 BSc
Bachelor of Science
University College London


Ageing|*|Alzheimer's disease|*|Biophysics|*|Brain|*|Brain imaging|*|Brain injury|*|Brain tumours in adults|*|Brain tumours in children|*|Cerebral palsy|*|Connectivity|*|Development|*|Diffusion tensor imaging (DTI)|*|Drug abuse - neurological consequences|*|Epilepsy|*|Gliomas|*|Hippocampus|*|Image analysis|*|Imaging|*|Ischaemic stroke|*|Language|*|MRI|*|Magnetic resonance imaging (MRI)|*|Memory|*|Motor control|*|Neuroanatomy|*|Neuroimaging|*|Neuropathology|*|Neurophysiology|*|Neuroscience|*|Regeneration|*|Speech|*|Stroke|*|Vision|*|Visual disorders|*|White matter mapping in neurological disease

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