Vasculitis and Autoinflammation Group
Leader: Dr Paul A Brogan
Dr Brogan is supported by the Great Ormond Street Children's Charity
- Dr Ying Hong, postdoctoral research assistant.
- Mrs Vanita Shah, senior vasculitis scientist.
- Dr Despina Eleftheriou, clinical research fellow.
- Dr Ebun Omoyinmi, postdoctoral research assistant.
The key areas of vasculitis research relate to further understanding of the aetiopathogenesis of vasculitis in the young, novel diagnostic and therapeutic interventions, systematic documentation of clinical vasculitis phenotype and development of a vasculitis database. In addition we are examining the use of novel therapeutics for these conditions, and have a special interest in rare disease clinical trial design. We are investigating the utility of using biomarkers derived from vasculitis research in other diseases such as juvenile dermatomyositis, Beçhet’s disease, and arterial stroke in children. We also have an expanding programme of work discovering novel monogenic forms of autoinflammatory disease in informative families. This relies on next-generation genetic techniques. The diseases we focus on include:
- Kawasaki disease, including genetics, and long-term outcomes;
- polyarteritis nodosa;
- ANCA associated vasculitides;
- Behcet's disease;
- childhood stroke;
- juvenile dermatomyositis in collaboration with Prof Wedderburn;
- autoinflammatory diseases, including CAPS, TRAPS, MKD, FMF, and CANDLEsyndrome.
Current research areas:
- Endothelial injury and repair in primary systemic vasculitis of the young
- Understanding the pathogenesis of idiopathic arterial stroke using novel biomarkers of endothelial injury
- Neutrophil microparticles and their role in ANCA associated vasculitides
- The vasculopathy of juvenile dermatomyositis
- Does Kawasaki disease predisposed to premature atherosclerosis later in life?
- Homozygosity mapping for the identification of novel autoinflammatory syndromes
- MYPAN trial. Multicentre randomized controlled trial of mycophenolate mofetil versus cyclophosphamide for the induction of remission of polyarteritis nodosa. P. Brogan et al (multicentre).
- Canakinumab in the treatment of cryopyrin associated periodic fever syndrome (CAPS).
- Clinical Trials Group
- Immunopathogenesis Group
- Inflammatory Muscle Disease Group
- Molecular Rheumatology Group
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