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Clinical Epidemiology, Nutrition and Biostatistics (CENB)
- Providing evidence through developing methods for analysing and linking data to improve healthcare policies, services and clinical practice for children and young people
- Improving surveillance and screening to better understand the longer-term effects of some conditions and infections in order to improve child health policies
- Conducting research on the impact of nutrition on the health and development of infants and children to develop both clinical and public health practice and professional training
- Providing short courses in statistical methods and software, and delivering statistical consultancy services
Epidemiological research depends crucially on high quality
data about the population. One source of such data are electronic health
records. These records often come from different sources and need to be
linked and then anonymised so we can use them in research for patient
and public health benefit.
Our work includes developing methods for analysing and linking data, as well as identifying how linking available data sources can improve our ability to conduct research and help with health services planning.
Using our secure computing service, epiLab, we are piloting systems for ensuring that data records can be accurately linked and anonymised.
A central theme to our research programme is the use of administrative data for child health research.
Our work is both methodological (e.g. minimally disclosive linkage between rich datasets, mixed methods) and applied (e.g. randomised controlled trials, cross country comparisons) and spans several topic areas (child and adolescent adversity, the interface between primary and secondary care, transitions between child and adult care, and healthcare related infections).
We work in collaboration with the Farr Institute of Health Informatics Research London and the Administrative Data Research Centre England
|Ruth Gilbert||Katherine Henderson|
|Katie Harron||Jenny Woodman|
The aim of our research into HIV is to understand the spread of HIV infection in pregnant women and their children in order to provide evidence for the best strategies to minimise mother-to-child transmission and to underpin policies on treating HIV in children and pregnant women. We are not only investigating the effects and progression of HIV in children born with it, but also the effects and progression of HIV in women who become pregnant and the management of the infection in pregnancy.
The NSHPC provides national surveillance of HIV infection in pregnancy and childhood in the UK and Ireland, including mother-to-child transmission of HIV.
Our research in this area focuses on understanding the
potential risks that infections acquired by the mother in pregnancy may
pose to the fetus and to the child at birth.
Accurate information on the frequency of the infection
being passed on to the fetus or baby is central to planning and
evaluating prevention, diagnosis and treatment policies and practice.
We study many different infections, including rubella
(German measles), HIV, cytomegalovirus, toxoplasmosis and hepatitis C.
The health effects of some infections acquired in early life may not be evident until many years later. Some of our research looks at these later health consequences of early-life infections.
We have the largest critical mass of expertise in paediatric nutrition research in Europe, spanning cognitive function, cardiovascular health, bone health, body composition and energy metabolism, dietetics, biochemistry and stable isotope research on nutrition and metabolism.
We are particularly interested in the impact of infant and childhood nutrition on long term health and neurodevelopment, notably cognitive function, cardiovascular disease and its risk markers, body fatness and bone health.
Surveillance and screening are closely interlinked, with
the evidence from surveillance studies often being used to decide on
appropriate screening, prevention and treatment policies.
We use our research and expertise to:
- contribute to developing better surveillance data gathering and research techniques
- contribute evidence that can be used to improve policies to prevent, diagnose and treat the conditions that we monitor and to minimise harm to those who are unaffected
- gain a better understanding of the longer-term effects that these conditions and infections have on individuals.
We are responsible for providing training in statistics to researchers and healthcare professionals in the Institute of Child Health and Great Ormond Street Hospital - we aim to maintain a high standard of research across the joint institution.
For more information see Statistics courses
We offer a statistical support service for researchers. This service is offered to researchers at the Institute of Child Health and Great Ormond Street Hospital, but it is also available to those outside the institutions. The aim of the service is to contribute to the maintenance of high standards of published research.
For more information see Statistical Support Services
The ever-increasing volume and diversity of information
makes it difficult for clinicians and others to keep up-to-date with the
latest developments. It is a major challenge for the NHS to make sure
that clinical and other decisions relevant to the care of sick children
and the prevention of illness and disability are based on the best
The Centre for Evidence-Based Child Health was set up to
address this challenge. Its education and research programme is designed
to help healthcare professionals to acquire the skills to critically
analyse the evidence that underpins their day-to-day decisions.
Page last modified on 03 sep 14 15:04