Research
2010: Role of iron deficiency on
neurocognitive impairment in Tanzanian children with sickle cell anaemia
(10NR17)
2010: The use of bulbar EMG in clinical assessment and management of
paediatric neurogenic dysphagia (10NR16)
2010: Is our clinical practise of intra-operative
Electrocorticography predictive of siezure outcome (10NR15)
2010: Retrospective record review of patients receiving VNS therapy
(10NR14)
2010: Exome sequencing in the epilepsies: discovery of rare variants
causing disease and influencing response to treatment (10NR13)
2010: The effects of antiepileptic drugs, genetic predisposition and
seizures on cognition in epilepsy (10NR09)
2010: Retrospective review of the clinical significance of
photosensitivity in early onset epilepsy (10NR07)
2010: Double blind trial to evaluate the benefits of fast forward
computerised auditory training vs placebo non-auditory training
(visuo-spatial) and no specific intervention on auditory processing and
listening skills of children with auditory processing disorders (10NR06)
2010: A pilot study to evaluate the maintenance of ketosis and
seizure control of fibre containing Ketocal liquid (10NR03)
2010: Landau Kleffner Syndrome: study of active phase and outcome
(10NR02)
2010: Contraclateral suppression of TOAEs in APD patients (10NR01)
2010: Paediatric UK demyelinating disease Longditudinal Study (PUDDLS) (09NR35)
2010: Frequency, features and impact of headache in children with moya moya disease (09NR36)
2009: Audit of current practice in the multidisciplinary assessment of children admitted to Tiger Ward at GOSH. (09NR01)
2009: An audit of current practice in the use of flunarizine in childhood headaches (09NR02)
2009: The prevalence, nature and spectrum of adverse outcomes following convulsive status epilepticus in childhood (09NR03)
2009: Intracranial aneurysms in childrne (09NR04)
2009: 3-dimensional ultrasound elastography in neurosurgery (09NR05)
2009: Use of botulinum toxin in the treatment of dystonia in childhood (09NR06)
2009: European Network of Expertise for rare Paediatric Neurological disorders (NEUROPED) (09 NR 07)
2009: Outcomes for children with complex communication needs assessed for communication aids cross-sectional/interview/questionnaire (09NR08)
2009: Preventing migrane in children and young people CTIMP (09NR09)
2009: The use of edrophonium in collaboration with stimulated single firbe EMG to diagnose myasthenia Case note Review (09NR10)
2009: Illness perceptions and coping styles in parents of children with intractable epilepsy Cross-sectional/interview/questionnaire (09NR11)
2009: Oxygen desaturation, carbondioxide tension and cerebrovascular reactivity to carbon dioxide Cohort study (09NR12)
2009: Eletromyoraphic markers of significant nerve damage appear in Neonatal Brachial plexopathy (NBP) (09NR13)
2009: Clinical and radiological features of arterial ischemic stroke in children without cerebral vasculopathy - case note review (09NR14)
2009: Pleomoprophic Xanthoastrocytomas; not neessarily benign - case note review (09NR15)
2009: The clinical efficacy in the management of giant SEGA Case Note Review (09NR16)
2009: Investigation into the comparative affects of brain lesions and pain on executive function in sickle cell disease (09NR17)
2009: Outcome of surgery for extratemporal epilepsy - Case Note Review (09NR18)
2009: Epilepsy in children: incidence, aetiology, associated impairments, and prenatal risk factors Cohort study (09NR20)
2009: Review of Lipomyelocele - is there a roation of neural placode to the left Case note review (09NR21)
2009: Epilepsy genomics in childhood: finding the cause, directing treatment Human biological samples (09NR22)
2009: Efficacy and safety of eslicarbazepine acetate (bia 2-093) as adjunctive therapy for refractoyr partial seizures in children: a double blind, randomised, placebo-controlled, parallel group multicentre cliical trial SCO/BIA-2093-305 Eslicarbazepine Acetate CTIMP BIAL (Under negotiation - commerical) (09NR23)
2009: Epilepsy associated with apenoeic episodes in children with 1p 36 deletion syndrome case notre review (09NR24)2009: A randomised open label trial to assess the efficacy and tolerability of the ketogenic diet as a treatment for children with epilepsy aged under two years of age CTIMP (09NR25)
2009: Prognostic value of EEG in Hypsarrhythmia (09NR26)
2009: The use of quantative EEG power trending as an indicator of intracranial bleeds in patients undergoing intracranial monitoring (09NR27)
2009: Study evaluating betaferon's safety and tolerability in paediatric patients with multiple sclerosis (09NR28)
2009: Prevalence and clinical outcome of Rasmussen encephalitis in children (09NR29)
2009: Epilepsy and cognition: The role of sleep discharges in consolidation of learning (09NR30)
2009: Development of a parental understanding scale in child neurodisability (09NR31)
2009: Sickle cell disease in tanzania Wellcome Trust (pre-submission) ( 09NR32)
2009: Measuring the efficacy of computer communication intervention for children with cerebral palsy (09NR33)
2008 Diacomit post-marketing survey (08 NR 19)
2008 The impact of "storage bags" on interaction between children with cerebral palsy, developmentally aged 2- 3 years, and unfamiliar adusts (08 NR 18))
2008 Audit of telemetry admissions (08 NR 14)
2008 Epilepsy in infancy - Spectrum of aetiologies, natural history and outcome predictors (08 NR 02)
2008 Case note review of audit of children with idiopathic intracranial hypertension (IIH) (08 NR 01)
2008-2014 The International Collaboration Infantile Spasms study (ICISS) (08 NR 08)
2008-2010 Neuro-cognitive function in children with following hospital admission with septic illness and meningo-encephalitis (08 NR 13)
2008 Pilot study on the use of ketocal in infants 0-24 months as measured by intake and effect on GI symptoms (08 NR 15)
2008 Registry study for patients on medication for severe epilepsy (08 NR 24)
2008 Circulating microparticles and cerebral vasculopathy in sickle cell anaemia (08 NR 25)
2008 Multicentre, placebo controlled, double blind study to evaluate the efficacy and safety of bumetanide in neonates with seizures not responding to phenobarbitone (NEMO study = neonaltal seizure and epilepsy treatment with medication off patent (08 NR 26)
2008 Sensitivity and specificity of stimulated single fibre EMG in congenital myasthenic syndrome (08 NR 17)
2008-2011 The prevalence, nature and spectrum of epilepsies and their structural substrates five years following convulsive status epilepticus in childhood (07 NR 01)
2008-2009 The impact of reducing over treatment on quality of Life in Children with refractory epilepsy (07 NR 07)
2008 Case note review of audit of children with idiopathic intracranial hypertension (IIH) (08 NR 01)
2008-2014 The International Collaboration Infantile Spasms study (ICISS) (08 NR 08)
2006-2008: Relationship between early attention behaviours and later language, socio-communicative and cognitive development in children with visual impairment – a longitudinal study. Research question: Is there a relationship between early attention skills and later language, socio-communicative and cognitive outcomes in children with visual impairment? (06 NR 01)
2006-2008: European network for research on alternating hemiplegia in childhood for promoting small and medium size enterprises integration. The aim is to develop a database of this rare disorder within Europe to allow further research, particularly in relationship to treatment. (06 NR 05)
2006-2009: Study of outcome of childhood stroke (SOCS). Research question: 1. What is the impact of childhood stroke after one year on (i) motor, cognitive and behavioural function (ii) health related quality of life?. 2. What is the risk of a further clinical stroke within 12 months of the first? (06 NR 02)
2006-2009: Understanding auditory processing in children with early onset epilepsy. Research question: Are abnormalities of auditory processing seen in early onset epilepsy independent of cognitive status? (06 NR 03)
2006: A regional audit of children referred for neurophysiological confirmation of myasthenia gravis. Research question: Are children with clinically suspected myasthenia gravis investigated appropriately for congenital myasthenic syndrome after neurophysiological confirmation of disordered myoneural function? (06 NR 12)
2006: EEG findings in neonatal onset molybdenum co-factor deficiency. Research question: To describe the EEG findings in this condition as a retrospective audit of EEGs from previously unpublished cases identified at GOSH between 1997 and 2006. Have common features of EEGs in this condition been reported in the GOSH experience? (06 NR 13)
2006: Indications, complication and diagnosis of children undergoing muscle biopsy: a comparison between the metabolic and neurological teams. With the aim of drawing up a protocol for the investigation of children with suspected mitocondrial disease in children. Research question: Which children are we performing muscle biopsy on? What tests are we doing prior to muscle biopsy? Which children have complication as a result of biopsy? (06 NR 17)
2006: A randomised, double blind placebo controlled study to assess the safety, tolerability and efficacy of Topiramate as an adjunct to concurrent anticonvulsant therapy for infants (1-23 months of age) with refractory particle onset seizures. Research question: Is Topiramate effective in the treatment of focal epilepsy in children under 2 years of age? (06 NR 04)
2006 (4 months): Paediatric trans-oral surgery. Research question: What are the indications, techniques and results from our series of paediatric transoral surgery cases? (06 NR 19)
2006 (3 months): A clinical review of spinal dermal sinus tracts. Research questions: 1. An audit of surgical practice and outcome. 2. What is the relationahip between dermoid formation and the risk of meningitis? (06 NR 20)
2006: International infant hydrocephalus study. A multi-centre prospective randomised controlled study. (06 NR 06)
2006: An audit to compare the management of childhood stroke before and after publication of clinical guidelines. Research question: The aim of this audit is to evaluate the impact of recently published guidelines for the management of childhood stroke by comparing key aspects of investigation and management in two time periods, pre- and post dating publication. (06 NR 07)
2006: Study of relationship between EEG findings and clinical presentation in children with infantile neuroaxonal dystrophy (INAD). Research question: With a typical clinical presentation of INAD are the EEG findings sufficient to make a clinical diagnosis: (06 NR 08)
2006: Incidence and possible risk factors of posterior fossa syndrome in children following hindbrain tumour resection surgery. (06 NR 09)
2006: Factors affecting delay to diagnosis of arterial ischaemic stroke in children. Research questions: 1. What is the length of time between 1st symptoms and diagnosis in children seen at GOSH with first arterial ischaemic stroke (AIS)? 2. Is this influenced by age, type of AIS (anterior vs. posterior circulation), pattern of neurological deficit, site of presentation (GP vs hospital) or underlying risk factors? 3. What proportion of children seen at GOSH within the last 5 years would have arrived at a tertiary centre within a time frame to make thrombolysis feasible (6 hours)? (06 NR 10)
2006: Sciatic neuropathy in childhood: a tertiary paediatric hospital experience. Research questions: 1. What are the patterns of lesions in children referred to a tertiary neurophysiological centre with sciatic neuropathy? 2. How does the aetiology of the sciatic neuropathy relate to neurological outcome? (06 NR 11)
2005: Evaluation of an antibiotic-impregnated shunt system (bactiseal catheter) for the treatment of hydrocephalus in the paediatric age group. Research question: We will evaluate whether the use of bactiseal catheters makes a statistically significant difference to our current shunt infection rate. (04-NR-22)
2005: An in-depth study over time on the effect of child and parent factors on the perceived quality of life of children treated for a brain tumour. (05 NR 18)
2005: EEG activated fMRI in the investigation of children with epilepsy. (05 NR 19)
2005: Physiology and pathophysiology of polyols. (05 NR 20)
2005-2006: Epilepsy in infancy: Spectrum of aetiologies, natural history and outcome predictors. Research question: What is the clinical spectrum of epilepsies and underlying aetiologies in patients presenting between 1 month and two years of age? (04-NR-02)
2005-2006: A longitudinal investigation of Landau Kleffner syndrome: course, correlates and outcome. Research question: To explore the range of phenotypes in LKS, to determine their clinical correlates, and how these relate to medium and long-term outcome. (04-NR-21)
2005-2006: Screening and treatment of silent infarcts for children with sickle cell disease. A phase III multi-centre study. Research question: To determine whether blood transfusion therapy will limit strokes or new or progressive MRI lesions in children with silent cerebral infarcts. (04-NR-14)
2005-2006: Investigation of parental views of the assessment and feedback process, and assessment of need in children attending two neurodisability clinics. Research question: To evaluate parents' satisfaction with the neurodevelopmental assessment procedure of children attending two neurodisability clinics at GOSH, and to assess the nature, frequency and intensity of behaviour problems in those children. (04-NR-17)
2005-2009 Asthma and nocturnal hypoxemia in sickle cell anaemia (SAC) (05 NR 15)
2005-2006: Vein of Galen malformation: application of established scoring system, audit of management and outcome. Research question: How do children with vein of Galen malformation presenting to GOSH score on the currently recommended scoring system? How does this relate to their subsequent clinical course? (05 NR 16)
2005-2010 Protocol E06 An open randomised trial to assess the efficacy and safety of adjunctive vagus nerve stimulation versus adjunctive new AED treatment in children with refractory seizures (05 NR 04)
2005-2006: Brain imaging findings in children with vein of Galen malformation. Research question: What is the range of cerebral findings in children with vein of Galen malformation? Does this enable improved understanding of the mechanisms of brain injury in this group? (05 NR 17)
2004-2005: The role of plastic reorganisation of the ipsilateral corticospinal tract from the undamaged hemisphere in the development of motor skills following unilateral cerebral infarction in early childhood. Research question: Whether the potential for reorganisation of the unaffected hemispere following stroke is greater following lesions in early childhood than in later life. (04-NR-20)
2004-2006: Towards the establishment of standards of practice and the initiation of multi-centre clinical trials for neonates and children with stroke. Research question: The overall objective of this multi-centre study is to develop and conduct clinical trials in childhood stroke. Our specific aims within this pilot study are; 1) To establish a collaborative network of physicians and scientists with expertise in the field of childhood stroke and cerebrovascular disease to conduct clinical research studies; 2) to ascertain the numbers of newborns and children with ischaemic stroke, their stroke sub-types, and their current treatments within our 10 centers internationally over a 12 month period; 3) to develop an appropriate web-based database (which will be based at The Hospital for Sick Children, Toronto), and to utilise these data in the design of future multi-centre studies in childhood stroke. (03-NR-14)
2004-2006: Genetic polymorphisms in cerebral aneurysm and arteriovenous malformation formation, progression and rupture. Research question: Are functional polymorphic variants of the genes encoding for interleukin 6, endothelial nitric oxide synthase, angiotensin conversion enzyme, BK-1 receptor and heme-oxygenase 1 associated with cerebral aneurysm and arteriovenous malformation formation, progression and rupture? (04-NR-06)
2004-2007: Image guided proteomics in the investigation of hippocampal injury associated with status epilepticus in mice. Research question: To characterise the structural and molecular biological changes in the hippocampus associated with hippocampal injury and subsequent epileptogenesis following status epilepticus. (03-NR-22)
2004-2007: Cerebral hypoperfusion consequences in children with cerebrovascular disease: identifying potential targets for intervention. Research question: Are any of the functional consequences of childhood stroke or cerebrovascular disease secondary to potentially reversible cerebral hypoperfusion? (04-NR-01)
2004-2009:Identification and characterisation of molecular genetic alterations in paediatric astrocytoma, medulloblastoma and ependymoma using a combination of gene expression analysis and genomic analysis. Research question:We propose to identify and characterise genes which are altered in the 3 most common types of childhood brain tumours, including those involved in initial tumour development, malignant progression, recurrence and resistance to therapy. (04-NR-19)
2003-2008: The causes and consequences of seizures associated with Plasmodium falciparum infection. Main research question: To determine in a malaria endemic area: (i) if infection with Plasmodium falciparum is the most common cause of acute seizures in children admitted to hospital (ii) mechanisms by which Plasmodium falciparum infection caues seizures in children. (iii) if neurocognitive damage associated with seizures can be prevented by fos
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