Research
Our goal is to elucidate the genetic and developmental basis of congenital malformations. Our previous work in this area has uncovered novel genetic mechanisms and offered insights into mechanisms of development. Clinical and diagnosis and prognosis can thereby be improved, and in some cases there is the prospect of novel therapeutic intervention. The Unit is actively investigating several birth defect syndromes, but there is an emphasis on:
• Identification of genes involved in congenital heart defects and their role in heart morphogenesis
• Ciliopathies (including motile as well as primary cilia)
The main functional analyses concentrate on
• The role of thymosin β4 in development, inflammation and tissue repair
• Signaling events mediated by the primary cilium
• Developmental pathways controlled by Tbx1, Hic2 and Chd7
• The role of Hira in stem cells and early embryos
More detail is provided under individual research team leaders’ pages.
http://www.ucl.ac.uk/ich/research-ich/molecular-medicine/research_facilities
Page last modified on 12 oct 12 11:05
