Institute of Child Health
Papers of the month, April 2014
We are featuring two outstanding papers this month by researchers at the UCL Institute of Child Health (ICH) :
The first paper is with Dr Khalid Hussain as lead author, which reports to use of a new agent called sirolimus in four patients with severe hyperinsulinemic hypoglycemia for whom the only alternative option would have been subtotal pancreatectomy. All patients had a good improvement in their hypoglycemia in response to this treatment with no major adverse effects.
- Link to paper in the New England Journal of Medicine (NEJM): Sirolimus Therapy in Infants with Severe Hyperinsulinemic Hypoglycemia.
- Dr Khalid Hussein is part of the Genetics and Epigenetics in Health and Disease Section of the Genetics and Genomic Medicine Programme at ICH.
The second paper is from Dr Claire Townsend,
Dr Mario Cortina- Borja, Dr Claire Thorne, Professor Catherine Peckham and Professor Pat Tookey which was published in AIDS and presents
definite evidence that mother to child transmission of HIV rates in the UK and Ireland
have reached an all-time low of 5 per 1,000 births in 2000 to 20111, which is a
very substantial reduction.
- Link to paper in AIDS: Earlier initiation of ART and further decline in mother-to-child HIV transmission rates, 2000-2011.
- The researchers are part of the Clinical Epidemiology and Nutrition Section of the Population, Policy and Practice Programme at ICH.