Using prospective motion correction to increase paediatric MRI quality and sensitivity

Supervisors: Dr David Carmichael, Dr Chris Clark and Dr Torsten Baldeweg

To develop and optimise a scan protocol that for robust head motion consisting of fMRI, FLASH and DTI, sequences with prospective motion correction utilised in a way that maximises image quality and stability.

To demonstrate the improvement in fMRI sensitivity from motion correction and its limitations i.e. the range of recoverable scan-scan movement with comparison to standard retrospective analysis.

To extend the motion tracking evaluation to EEG-fMRI and evaluate its sensitivity by suppression of variance due to motion.

1) Modelling large motion events in fMRI studies of patients with epilepsy: Lemieux L, Salek-Haddadi A, Lund TE, Laufs H, Carmichael D. Magn Reson Imaging. 2007 Jul;25(6):894-901.
2) Measurement and correction of microscopic head motion during magnetic resonance imaging of the brain: Maclaren J, Armstrong BS, Barrows RT, Danishad KA, Ernst T, Foster CL, Gumus K, Herbst M, Kadashevich IY, Kusik TP, Li Q, Lovell-Smith C, Prieto T, Schulze P, Speck O, Stucht D, Zaitsev M. PLoS One. 2012;7(11):e48088.
3) Prevention of motion-induced signal loss in diffusion-weighted echo-planar imaging by dynamic restoration of gradient moments: Gumus K, Keating B, Poser BA, Armstrong B, Chang L, Maclaren J, Prieto T, Speck O, Zaitsev M, Ernst T. Magn Reson Med. 2013 Jul 2.
4) Prospective motion correction in brain imaging: a review: Maclaren J, Herbst M, Speck O, Zaitsev M. Magn Reson Med. 2013 Mar 1;69(3):621-36.
5)  Imaging in the surgical treatment of epilepsy: Duncan JS. Nat Rev Neurol. 2010 Oct;6(10):537-50.