3-year PhD Studentship jointly funded by UCL Impact and the Children's Policy Research Unit

Tracking of glycaemic control from diagnosis of type 1 diabetes in childhood and the future risk of acute and chronic complications

A 3-year PhD Studentship is available within the Policy Research Unit in the Health of Children, Young People and Families, UCL Institute of Child Health (www.ucl.ac.uk/cpru). The studentship will commence before the end of 2014 at a time of the successful applicants choosing. The student will be under the supervision of Professor Terence Stephenson and Dr Rakesh Amin with additional specialist clinical input from Dr Julie Edge of John Radcliffe Hospital, Oxford,

The purpose of the proposed investigation

Type 1 diabetes is a life-long condition which affects approximately 25,000 children and young people in the UK. Acute and chronic diabetes related complications are relatively rare in childhood but their pathogenesis begins from diagnosis of diabetes and are strongly linked to poor glycaemic control and duration of diabetes. Hence risk of developing complications are more common in adults who developed diabetes in childhood. There is evidence that that better glycaemic control through intensive insulin therapy from diagnosis reduces the risk of later vascular complications when compared to conventional treatment even after subsequent equalization of glycaemic control. This observation highlighted the importance of optimizing glycaemic control as early as possible in the course of diabetes. However this "metabolic memory" has not been described in childhood onset T1D or in any population followed from diagnosis of diabetes.

In this project, the student will use linked routinely collected data from the national diabetes audits and other sources to track the outcome of children with T1D into adulthood in relation to early glycaemic control. The results will have direct implications for clinical care of children and young people with T1D

Applicants will normally be graduates in a medical or health sciences subject. They should have, or expect to receive a first class honours or an upper second class degree, and should be ordinarily resident in the UK or EU. A non-EU student who has been granted ‘Indefinite Leave to Remain in the UK’ is entitled to be considered for the Studentship. The student will receive a stipend of £15,863 per annum as well as the cost of tuition fees at the UK/EU rate.

Enquiries about the project can be made to Dr Amin (rakesh.amin@ucl.ac.uk)

To apply, please send a current CV including the contact details of two professional referees as well as a cover letter to Linda Haines (linda.haines@ucl.ac.uk) copying in d.charalampoloulos@ucl.ac.uk

Interviews for this post will be held on Friday 12th September 2014

Deadline for receipt of applications: Friday 15th August 2014