Monday 11th November 2013
Time: 1.00-2.00pm (tea/coffee available from 12.40pm)
Kennedy Lecture Theatre, UCL Institute of Child Health.
If you would like to suggest someone as a speaker, please contact the OWL Committee Chair, Professor Christine Kinnon.
For any administrative questions, please contact Nicole Hofmans.
Evidence based ENT. Utopia?
Part of the Otto Wolff Lecture series 2013
Professor Anne Schilder
NIHR Research Professor, Professor of Paediatric Otorhinolaryngology, University College London & University Medical Centre Utrecht, Honorary Consultant ENT Surgeon, Royal National Throat, Nose and Ear Hospital ENT Clinical Trials Programme, University College London
The clinical needs met by Ear, Nose and Throat (ENT) Surgery include the commonest disabilities in the population (deafness and dizziness) and the commonest illnesses (upper respiratory conditions) and account for up to 20% of GP referrals to secondary care. Despite its importance to health and health care resources, the evidence base for the management of many ENT conditions is poor. With limited evidence easily misinterpreted as limited effectiveness, common ENT operations like sinus surgery are often labelled as low priority procedures by clinical commissioning groups which may lead to inequality of access to care. It is therefore essential that high quality studies comparing surgical and non-surgical treatment strategies for ENT conditions are initiated.
Paediatric ENT has recognised this and set an example of how such studies can be carried out successfully in a multidisciplinary setting. Randomised controlled trials of antibiotics and surgical interventions like adenoidectomy for ENT infections in children have not only generated evidence to guide clinical practice, but also provided a rich source of socio-demographic and biological data for prognostic and etiologic research.
Professor Schilder started her scientific career in 1989 as a
PhD student in Medical Sciences, and completed her PhD in 1993 while training as an Otorhinolaryngologist (ENT
surgeon) in Nijmegen and Antwerp. In 1995 she qualified as an ENT surgeon, was
awarded an MSc in Epidemiology and continued my career as a Clinician Scientist
at the University Medical Centre Utrecht, where she became Head of Paediatric
Otorhinolaryngology in 1999 and built the Paediatric ENT Department into a
national referral centre for children with upper respiratory disease. In parallel
and in close collaboration with expert colleagues at the Departments of
Epidemiology and Paediatrics, they established a world-class multidisciplinary
research centre in this field.
As Chief and Principal Investigator she acquired large peer-reviewed, governmental and industrial grants for our multi-centre trials of medical and surgical management of upper respiratory disease. Within these trials they established strong links with a network of General Practitioners and ENT Surgeons who were instrumental in the recruitment process. The trials have been influential in the way global health-care systems think about the management of children with these conditions and have been translated in national and international evidence-based guidelines and health policies. As well as generating the evidence upon which everyday clinical decisions are made, the trials have provided a rich source of socio-demographic and biological data for prognostic and aetiologic research. As such, they have proven a tool for true translational research. In 2009 Prof Schilder was appointed as Professor in Paediatric Otorhinolaryngology at University Utrecht and she is the President of the European Society of Paediatric Otorhinolaryngology.
In 2011, with UCL/UCLH CBRC support, UCL recruited Professor Schilder on secondment from Utrecht University to establish a programme for clinical trials in Otorhinolaryngology and Associated Specialties at UCL Partners. Convinced of the potential and power of the NHS, NIHR and UCLP for delivering the big trials that ENT internationally requires, and for implementing change across populations, she has decided to continue her career in the UK. She successfully applied for an NIHR Research Professorship with the remit to provide the Evidence Base for ENT and has been appointed Professor of Paediatric Otorhinolaryngology at UCL (tenure), chair of the NIHR CCRN national ENT Specialty Group, Joint Co-ordinating Editor of the Cochrane Collaboration ENT Disorders Group, the Royal College of Surgeons of England Surgical Specialty Lead for ENT and honorary ENT consultant at the Royal National Throat, Nose and Ear Hospital, allowing her team at UCL to become the focal point for clinical trials in ENT nationally and internationally.