Monday 8th July 2013
Time: 1.00-2.00pm (tea/coffee available from 12.40pm)
Kennedy Lecture Theatre, UCL Institute of Child Health.
If you would like to suggest someone as a speaker, please contact the OWL Committee Chair, Professor Christine Kinnon.
For any administrative questions, please contact Nicole Hofmans.
The clinical pathology of HIV in children: how much do we know?
Part of the Otto Wolff Lecture series 2013
Professor Sebastian Lucas
Emeritus Professor of Pathology, School of Medicine, King College London
Perinatal HIV transmission results in the death of half of those children infected, by the age of 2 years – from pneumocystosis, bacterial infections, diarrhoeal diseases, meningitis and measles – in the absence of cART. These are the ‘rapid progressors’
The ‘slow progressors’ may not present until their ‘teens, and clinico-pathologically have a different spectrum of disease, much of which awaits full explication. Environment determines much of the opportunistic disease that develops (eg TB).
The lecture will present the gross and histological pathology of paediatric HIV disease. And will highlight those areas where we are still ignorant of aetiology: for example the CNS neurodevelopmental syndromes and the chronic lung disease prevalent in Africa. It will end with a cautionary tale about the virulence of HIV infection per se and the damage it causes in tissues.
Sebastian Lucas is Emeritus Professor of Pathology at KCL School of Medicine. He has specialised in infectious and tropical disease pathology since the late 1970s, and worked on HIV clinical pathology since the mid-1980s. Working in Africa and London, he has studied what HIV does in adults and children through autopsy and biopsy material, and wishes for greater liaison between clinicians and pathologists.