In terms of systems biology, the group has a special interest in:
- The role of renin-angiotensin systems (RAS), exploring its role in cardiac growth and physical performance. This has led to work mitochondrial biology, with Prof Mike Duchen’s group.
- The musculoskeletal response to exercise and disease, with themes addressing bone loss and muscle wasting at altitude and in the critically ill.
- The causes and responses to severe systemic inflammatory disease, such as that seen in acute pancreatitis.
- The human adaptive response to hypoxia. Such work ranges from human studies in critical care, studies of the physiological response to extreme altitude, and genetic studies of mountaineers, mice in Hawaii, and human populations in Tibet.
Key collaborators include:
Prof Mike Grocott (UCL and Southampton), Peter Robbins (Oxford), Gianpiero Cavalleri (Ireland), Cynthia Beale (USA), Lorna Moore (USA), Jay Stortz (USA), Prof Steve Humphries (UCL), Prof Mike Duchen (UCL), Prof Phillippa Talmud (UCL).