A variety of different ADAMTS13 assays are available within the HRU, including: activity assays utilising collagen binding, Fret-VWF73 or chromogenic VWF73 peptide substrate; IgG anti-ADAMTS13 antibody assays, antigen assays; and genetic analysis.
- Sample Collection (Word Document)
- Handling and Shipping Guidance (Word Document)
- ADAMTS13 Assay Request Form
As you may know, until December 2012, we were providing a free ADAMTS13 assay service for NHS patients in the UK who had entered in the UK TTP Registry. This led, in our opinion, to a major advance in the diagnosis of acute TTP and other related TMAs and hopefully led to an increase in appropriate treatment being carried out for all these patients.
Unfortunately, our MRC funding expired and we have to pay for the reagents, consumables, equipment, facilities and scientific staff who perform the assays.
From 1st January 2013, we have charged £100 for ADAMTS13 activity assays on samples from NHS patients.
An additional £50 is charged for IgG anti-ADAMTS13 assays if these are felt to be appropriate (based on the results of the activity assay and any clinical information provided).
A similar pricing structure will exist for patients from renal units with a suspected diagnosis of aHUS.
Please provide an institutional purchase order number for each request (standing orders may be more convenient if samples are regularly sent).
For private patients and those living outside the UK, we will charge up to £300 per sample (this price will include an ADAMTS13 activity assays and IgG anti-ADAMTS13 assays as appropriate). The Institution requesting the assay must meet all shipping costs. Invoices will be issued by UCL Finance Division, who will ensure that prompt payment is met. Please provide an institutional purchase order number for each request (standing orders may be more convenient if samples are regularly sent).
Collaborative Reseach & Clinical Trials
For collaborative research studies and assays for clinical trials, please contact:
Dr Ian Mackie