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Can Large MPAs Protect Tuna and Sharks?

Thu, 04 Jun 2015 14:04:29 +0000

a guest blog by David Curnick, written for the 2015 Write About Research Competition. With a global human population of over 7 billion it is becoming ever more important to manage our natural resources effectively. For centuries, the oceans have been seen as an endless bounty, ripe for harvesting. However, this simply isn’t the case […]

The post Can Large MPAs Protect Tuna and Sharks? appeared first on GEE Research.

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Dr Michal Malecki (Bahler Group) awarded prestigious Newton International Fellowship

15 January 2014

Michal Malecki

Dr Michal Malecki has recently secured a prestigious Newton International Fellowship which is jointly run by The British Academy and the Royal Society. This postdoctoral fellowship is to work on the function of cytoplasmic non-canonical RNA polymerases in fission yeast.

Non-canonical RNA polymerases (ncPAPs) modify RNA molecules by adding nucleotides to their 3’-ends without the need of a starter or template. Modifications catalyzed by ncPAPs have different consequences on RNA fate: they can destabilize and rapidly degrade transcripts, but they can also stabilize transripts, facilitate processing steps, or regulate translation ability. The ability to modify pre-existing RNAs makes ncPAPs ideal candidates for shaping the transcriptome at a post-transcriptional level.


The role of ncPAPs in RNA metabolism has recently started to be investigated. There are still many unsolved questions, most notably concerning the function of ncPAPs in the cytoplasm. In humans, cytoplasmic ncPAPs investigated so far affect cellular differentiation, senescence, synaptic plasticity, aging, and may be important in tumor suppression. The human genome codes for seven potential ncPAPs, with functions in both the cytoplasm and nucleus. The genome of fission yeast (Schizosaccharomyces pombe) encodes six potential ncPAPs, which makes it a highly attractive organism to investigate the functions of these intriguing proteins.


Four out of six S. pombe ncPAPs localise in the cytoplasm or both in the nucleus and cytoplasm. To study the function of these four cytoplasmic ncPAPs, we will apply multiple genetic, genomic and biochemical approaches, and then integrate the resulting data for insight into general biological principles.

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