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The Best of Both Worlds:Planning for Ecosystem Win-Wins

Sun, 16 Nov 2014 12:25:44 +0000

The normal and healthy function of ecosystems is not only of importance in conserving biodiversity, it is of utmost importance for human wellbeing as well. Ecosystems provide us with a wealth of valuable ecosystem services from food to clean water and fuel, without which our societies would crumble. However it is rare that only a […]

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Planning for Ecosystem Win-Wins
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Life Aquatic: Diversity and Endemism in Freshwater Ecosystems

Thu, 06 Nov 2014 11:22:07 +0000

Freshwater ecosystems are ecologically important, providing a home to hundreds of thousands of species and offering us vital ecosystem servies. However, many freshwater species are currently threatened by habitat loss, pollution, disease and invasive species. Recent research from GEE indicates that freshwater species are at greater risk of extinction than terrestrial species. Using data on […]

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Diversity and Endemism in Freshwater Ecosystems
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Handicaps, Honesty and VisibilityWhy Are Ornaments Always Exaggerated?

Thu, 23 Oct 2014 13:30:30 +0000

Sexual selection is a form of natural selection that favours traits that increase mating success, often at the expense of survival. It is responsible for a huge variety of characteristics and behaviours we observe in nature, and most conspicuously, sexual selection explains the elaborate ornaments such as the antlers of red deer and the tail […]

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Why Are Ornaments Always Exaggerated?
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PREDICTS Project: Land-Use Change Doesn’t Impact All Biodiversity Equally

Mon, 13 Oct 2014 09:17:53 +0000

Humans are destroying, degrading and depleting our tropical forests at an alarming rate. Every minute, an area of Amazonian rainforest equivalent to 50 football pitches is cleared of its trees, vegetation and wildlife. Across the globe, tropical and sub-tropical forests are being cut down to make way for expanding towns and cities, for agricultural land […]

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Calculated Risks: Foraging and Predator Avoidance in Rodents

Fri, 03 Oct 2014 10:07:08 +0000

Finding food is one of the most important tasks for any animal – most animal activity is focused on this job. But finding food usually involves some risks – leaving the safety of your burrow or nest to go out into a dangerous world full of predators, disease and natural hazards. Animals should therefore be […]

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Foraging and Predator Avoidance in Rodents
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Dr Michal Malecki (Bahler Group) awarded prestigious Newton International Fellowship

15 January 2014

Michal Malecki

Dr Michal Malecki has recently secured a prestigious Newton International Fellowship which is jointly run by The British Academy and the Royal Society. This postdoctoral fellowship is to work on the function of cytoplasmic non-canonical RNA polymerases in fission yeast.

Non-canonical RNA polymerases (ncPAPs) modify RNA molecules by adding nucleotides to their 3’-ends without the need of a starter or template. Modifications catalyzed by ncPAPs have different consequences on RNA fate: they can destabilize and rapidly degrade transcripts, but they can also stabilize transripts, facilitate processing steps, or regulate translation ability. The ability to modify pre-existing RNAs makes ncPAPs ideal candidates for shaping the transcriptome at a post-transcriptional level.


The role of ncPAPs in RNA metabolism has recently started to be investigated. There are still many unsolved questions, most notably concerning the function of ncPAPs in the cytoplasm. In humans, cytoplasmic ncPAPs investigated so far affect cellular differentiation, senescence, synaptic plasticity, aging, and may be important in tumor suppression. The human genome codes for seven potential ncPAPs, with functions in both the cytoplasm and nucleus. The genome of fission yeast (Schizosaccharomyces pombe) encodes six potential ncPAPs, which makes it a highly attractive organism to investigate the functions of these intriguing proteins.


Four out of six S. pombe ncPAPs localise in the cytoplasm or both in the nucleus and cytoplasm. To study the function of these four cytoplasmic ncPAPs, we will apply multiple genetic, genomic and biochemical approaches, and then integrate the resulting data for insight into general biological principles.

Page last modified on 15 jan 14 14:28