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PREDICTS Project: Land-Use Change Doesn’t Impact All Biodiversity Equally

Mon, 13 Oct 2014 09:17:53 +0000

Humans are destroying, degrading and depleting our tropical forests at an alarming rate. Every minute, an area of Amazonian rainforest equivalent to 50 football pitches is cleared of its trees, vegetation and wildlife. Across the globe, tropical and sub-tropical forests are being cut down to make way for expanding towns and cities, for agricultural land […]

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Calculated Risks: Foraging and Predator Avoidance in Rodents

Fri, 03 Oct 2014 10:07:08 +0000

Finding food is one of the most important tasks for any animal – most animal activity is focused on this job. But finding food usually involves some risks – leaving the safety of your burrow or nest to go out into a dangerous world full of predators, disease and natural hazards. Animals should therefore be […]

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Foraging and Predator Avoidance in Rodents
appeared first on GEE Research.

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Applying Metabolic Scaling Laws to Predicting Extinction Risk

Thu, 25 Sep 2014 10:32:49 +0000

The Earth is warming. That much were are now certain of. A major challenge for scientists hoping to ameliorate the effect of this on biodiversity is to predict how temperature increases will affect populations. Predicting the responses of species living in complex ecosystems and heterogenous environments is a difficult task, but one starting point is […]

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The Importance of Size in the Evolution of Complexity in Ants

Tue, 16 Sep 2014 10:14:37 +0000

Ants are amongst the most abundant and successful species on Earth. They live in complex, cooperative societies, construct elaborate homes and exhibit many of the hallmarks of our own society. Some ants farm crops, others tend livestock. Many species have a major impact on the ecosystems they live in, dispersing seeds, consuming huge quantities of […]

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Understanding Catfish Colonisation and Diversification in The Great African Lakes

Fri, 05 Sep 2014 10:29:42 +0000

Why some regions or habitats contain vast, diverse communities of species, whilst others contain only relatively few species, continues to be the subject of scientific research attempting to understand the processes and conditions that allow and adaptive radiation. The Great African Lakes exist as freshwater ‘islands’, with spectacularly high levels of biodiversity and endemism. They […]

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Dr Michal Malecki (Bahler Group) awarded prestigious Newton International Fellowship

15 January 2014

Michal Malecki

Dr Michal Malecki has recently secured a prestigious Newton International Fellowship which is jointly run by The British Academy and the Royal Society. This postdoctoral fellowship is to work on the function of cytoplasmic non-canonical RNA polymerases in fission yeast.

Non-canonical RNA polymerases (ncPAPs) modify RNA molecules by adding nucleotides to their 3’-ends without the need of a starter or template. Modifications catalyzed by ncPAPs have different consequences on RNA fate: they can destabilize and rapidly degrade transcripts, but they can also stabilize transripts, facilitate processing steps, or regulate translation ability. The ability to modify pre-existing RNAs makes ncPAPs ideal candidates for shaping the transcriptome at a post-transcriptional level.


The role of ncPAPs in RNA metabolism has recently started to be investigated. There are still many unsolved questions, most notably concerning the function of ncPAPs in the cytoplasm. In humans, cytoplasmic ncPAPs investigated so far affect cellular differentiation, senescence, synaptic plasticity, aging, and may be important in tumor suppression. The human genome codes for seven potential ncPAPs, with functions in both the cytoplasm and nucleus. The genome of fission yeast (Schizosaccharomyces pombe) encodes six potential ncPAPs, which makes it a highly attractive organism to investigate the functions of these intriguing proteins.


Four out of six S. pombe ncPAPs localise in the cytoplasm or both in the nucleus and cytoplasm. To study the function of these four cytoplasmic ncPAPs, we will apply multiple genetic, genomic and biochemical approaches, and then integrate the resulting data for insight into general biological principles.

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