GEE News Publication
A A A

Gee Research Blog

Dating Mammalian Evolution

Fri, 28 Mar 2014 15:14:37 +0000

When the age of the dinosaurs ended around 65 million years ago, mammals stepped in to fill the gap, and the age of the placentals began. However, whether early placental mammals were already present on Earth before the demise of the dinosaurs has been the subject of a long standing debate. Recent research in GEE [...]

Read more...

The Delicate Balance of Effect and Response

Tue, 18 Feb 2014 11:50:36 +0000

We may not always be aware of it, but many wild plants, animals, fungi and even bacteria, provide crucial services to us which keep the ecosystems of Earth functioning. Environmental changes caused by human activities are now threatening many species, and those that cannot withstand these changes may be lost forever, potentially taking the services [...]

Read more...

It’s All in the Wrist

Fri, 20 Dec 2013 16:18:20 +0000

The evolution of the primate wrist has been dramatic, enabling primates to adapt to a wide variety of lifestyles and walking styles, including tree-swinging, climbing and terrestrial walking both on four legs and two. In hominids, the evolution of the bipedal gait freed up the forelimbs for tool use, and the wrist evolved independently from [...]

Read more...

The Transcriptional Profile of A ‘Wingman’

Wed, 27 Nov 2013 14:25:48 +0000

In many species, males have special adaptations to attract females. From antlers to stalk-eyes, to bright plumage and beards, males across the animal kingdom work hard to look attractive to the opposite sex. In some species, looking good isn’t enough, though. Male wild turkeys need a less attractive ‘wingman’ to help him attract a woman. [...]

Read more...

Damage and Fidelity: The Role of the Female Germline in mtDNA Inheritance

Mon, 11 Nov 2013 15:13:12 +0000

Billions of years ago, one single-celled organism engulfed another, beginning a symbiotic interaction that would change live on Earth forever. The mitochondria are what remains of this symbiotic event, and are responsible for producing energy in all eukaryotic cells. Derived from a free-living organism, they carry their own genes, but these genes are at risk [...]

Read more...

MRC Career Development Award for Doug Speed

3 February 2014

Congratulations to Doug Speed who has been successful in gaining an MRC career development award in biostatistics.

The MRC has identified advanced biostatistics as a methodology of strategic importance to UK science.  The MRC Biostatistics Fellowship is one of a number of qualitative and quantitative schemes supported by the MRC under the Strategic Skills Fellowships banner. The scheme expects to make up to 3 awards a year.

The aim of the scheme is to encourage broad training programmes in biostatistics to support talented researchers who have recently completed their PhDs and wish to move into statistically based health related research.

The aim of Doug's fellowship is to develop methods for better understanding the genetics behind complex traits, then to apply these methods to improve prediction and classification of diseases. There are many diseases which we know to be highly heritable, but for which we have struggled to understand the genetic factors influencing risk.  For example, twin and family studies have shown that at least 50% of an individual's risk of developing epilepsy can be explained by genetics, but so far, we have discovered only a handful of genetic mutations impacting risk which in total explain less than 1% of the variation.

To better understand these diseases, we need to devise methods which allow for the fact that there are likely to be many hundreds, if not thousands, of variants affecting risk. Even though we are unlikely to discover the majority of these, we can still benefit greatly by determining which types of variants are causal. This information can then be accommodated in prediction models, which can be used to select individuals at high risk of developing a condition, and also for classification; many diseases, especially neurological traits, are highly heterogeneous, so diagnoses and prognoses will benefit by being able to use genetics to group individuals into subtypes.


Page last modified on 03 feb 14 11:44