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Competitive Generosity Drives Charitable Donations

Fri, 17 Apr 2015 12:09:46 +0000

Unconditional generosity is a characteristic of humans on which we pride ourselves, and billions of dollars is donated to hundreds of thousands of charitable organisations every year. But look at it from an evolutionary perspective, and this trait seems difficult to explain. In some situations, giving may have evolved to advertise positive characteristics of the […]

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Annoucing the Winners of the Write About Research Competition

Fri, 10 Apr 2015 13:49:07 +0000

Thanks to everyone who entered our Write About Research competition. We received some great entries from GEE students and postdocs, covering a broad range of topics from conservation to genetics. The entries will be posted here over the coming months, so watch this space! The Winners are… Drum roll please … WINNER: David Curnick – […]

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Male Promiscuity Boosts Role of Chance in Sex Chromosome Evolution

Thu, 19 Mar 2015 15:02:31 +0000

Humans, like all mammals and birds, determine sex with chromosomes. Whether a fertilised egg develops into a male or female depends on what chromosomes it carries Scientists have long recognised that genes evolve a little differently on the sex chromosomes, and recent research in GEE suggests this may be due to differing patterns of inheritance […]

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Sloths Move Slow, Evolve Fast

Wed, 11 Mar 2015 18:20:41 +0000

Sloths might be notorious for their leisurely pace of life, but research published last year shows they are no slow coaches when it comes to evolution. Sloths, as we know and love them, are small, slow-moving creatures found in the trees of tropical rainforests. But modern sloths are pretty odd compared to their extinct relatives. […]

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Write About Research – A GEE Research Blog Competition

Tue, 03 Mar 2015 15:28:43 +0000

The GEE Research blog communicates UCL science with a wider, non-specialist audience, by providing short summaries of recent research in the department of UCL Genetics, Evolution and Environment. This provides an opportunity to engage with a broad audience, including other academics, students, members of the public, and even businesses and policy-makers. It is a great […]

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MRC Career Development Award for Doug Speed

3 February 2014

Congratulations to Doug Speed who has been successful in gaining an MRC career development award in biostatistics.

The MRC has identified advanced biostatistics as a methodology of strategic importance to UK science.  The MRC Biostatistics Fellowship is one of a number of qualitative and quantitative schemes supported by the MRC under the Strategic Skills Fellowships banner. The scheme expects to make up to 3 awards a year.

The aim of the scheme is to encourage broad training programmes in biostatistics to support talented researchers who have recently completed their PhDs and wish to move into statistically based health related research.

The aim of Doug's fellowship is to develop methods for better understanding the genetics behind complex traits, then to apply these methods to improve prediction and classification of diseases. There are many diseases which we know to be highly heritable, but for which we have struggled to understand the genetic factors influencing risk.  For example, twin and family studies have shown that at least 50% of an individual's risk of developing epilepsy can be explained by genetics, but so far, we have discovered only a handful of genetic mutations impacting risk which in total explain less than 1% of the variation.

To better understand these diseases, we need to devise methods which allow for the fact that there are likely to be many hundreds, if not thousands, of variants affecting risk. Even though we are unlikely to discover the majority of these, we can still benefit greatly by determining which types of variants are causal. This information can then be accommodated in prediction models, which can be used to select individuals at high risk of developing a condition, and also for classification; many diseases, especially neurological traits, are highly heterogeneous, so diagnoses and prognoses will benefit by being able to use genetics to group individuals into subtypes.


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