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Male Promiscuity Boosts Role of Chance in Sex Chromosome Evolution

Thu, 19 Mar 2015 15:02:31 +0000

Humans, like all mammals and birds, determine sex with chromosomes. Whether a fertilised egg develops into a male or female depends on what chromosomes it carries Scientists have long recognised that genes evolve a little differently on the sex chromosomes, and recent research in GEE suggests this may be due to differing patterns of inheritance […]

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Sloths Move Slow, Evolve Fast

Wed, 11 Mar 2015 18:20:41 +0000

Sloths might be notorious for their leisurely pace of life, but research published last year shows they are no slow coaches when it comes to evolution. Sloths, as we know and love them, are small, slow-moving creatures found in the trees of tropical rainforests. But modern sloths are pretty odd compared to their extinct relatives. […]

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Write About Research – A GEE Research Blog Competition

Tue, 03 Mar 2015 15:28:43 +0000

The GEE Research blog communicates UCL science with a wider, non-specialist audience, by providing short summaries of recent research in the department of UCL Genetics, Evolution and Environment. This provides an opportunity to engage with a broad audience, including other academics, students, members of the public, and even businesses and policy-makers. It is a great […]

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Was Fermentation Key to Yeast Diversification?

Tue, 17 Feb 2015 15:30:43 +0000

From bread to beer, yeast has shaped our diets and our recreation for centuries. Recent research in GEE shows how humans have shaped the evolution of this important microorganism. As well as revealing the evolutionary origins of modern fission yeast, the new study published in Nature Genetics this month shows how techniques developed for detecting […]

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Planning for the Future – Resilience to Extreme Weather

Thu, 15 Jan 2015 15:13:14 +0000

As climate change progresses, extreme weather events are set to increase in frequency, costing billions and causing immeasurable harm to lives and livelihoods. GEE’s Professor Georgina Mace contributed to the recent Royal Society report on “Resilience to Extreme Weather”, which predicts the future impacts of increasing extreme weather events, and evaluates potential strategies for improving […]

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A matter of priorities: Bacteria evolved way to safeguard crucial genetic material, Prof Nick Luscombe publishes in Nature

23 April 2012

Different genes mutate at different rates, in the bacterium E. coli.
Credit: EMBL / I. Martincorena.

Just as banks store away only the most valuable possessions in the most secure safes, cells prioritise which genes they guard most closely, researchers at the European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI) have found. The study, published online today in Nature, shows that bacteria have evolved a mechanism that protects important genes from random mutation, effectively reducing the risk of self-destruction. The findings answer a question that has been under debate for half a century and provide insights into how disease-causing mutations arise and pathogens evolve.

“We discovered that there must be a molecular mechanism that preferentially protects certain areas of the genome over others,” says Nicholas Luscombe, who led the research at EMBL-EBI. “If we can identify the proteins involved and uncover how this works, we will be even closer to understanding how mutations that lead to diseases like cancer can be prevented.”

Read more in EMBL Press Release 22 April 2012 - A matter of priorities


Nick Luscombe

Nick Luscombe

Other links:

Professor Nick Luscombe (EMBL)

Lab website
GEE News regarding Nick Luscombe's appointment in March 2012

University College London (joint appointment)

UCL Genetics Institute, Dept of Genetics, Evolution & Environment, 

University College London, Gower Street, London WC1E 6BT, UK


Cancer Research UK London Research Institute (joint appointment)

44 Lincoln's Inn Fields, London WC2A 3LY, UK


Okinawa Institute of Science & Technology (visiting faculty)

1919-1 Tancha, Onna-son, Kunigami-gun, Okinawa 904-0495, Japan 

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