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Predicting Extinction Risk:The Importance of Life History and Demography

Mon, 28 Jul 2014 14:46:17 +0000

The changing climate is no longer simply a concern for the future, it is a reality. Understanding how the biodiversity that we share our planet with will respond to climate change is a key step in developing long-term strategies to conserve it. Recent research by UCL CBER’s Dr Richard Pearson identifies the key characteristics that [...]

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It Pays to Be Different:Evolutionary Distinctiveness and Conservation Priorities

Tue, 15 Jul 2014 13:15:25 +0000

The world is currently experiencing an extinction crisis. A mass extinction on a scale not seen since the dinosaurs. While conservationists work tirelessly to try and protect the World’s biodiversity, it will not be possible to save everything, and it is important to focus conservation efforts intelligently. Evolutionary distinctiveness is a measure of how isolated [...]

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Synthetic Biology and Conservation

Mon, 07 Jul 2014 16:20:18 +0000

Synthetic biology, a hybrid between Engineering and Biology, is an emerging field of research promising to change the way we think about manufacturing, medicine, food production, and even conservation and sustainability. A review paper released this month in Oryx, authored by Dr Kent Redford, Professor William Adams, Dr Rob Carlson, Bertina Ceccarelli and CBER’s Professor [...]

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Measure Twice, Cut Once: Quantifying Biases in Sexual Selection Studies

Wed, 25 Jun 2014 10:44:30 +0000

Bateman’s principles are conceptually quite simple, but form the basis of our understanding of sexual selection across the animal kingdom. First proposed in 1948, Bateman’s three principles posit that sexual selection is more intense in males than in females for three reasons: 1) males show more variability in the number of mates they have (mating [...]

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Technology for Nature?

Mon, 16 Jun 2014 13:23:54 +0000

Many of our greatest technological advances have tended to mark disaster for nature. Cars guzzle fossil fuels and contribute to global warming; industrialised farming practices cause habitat loss and pollution; computers and mobile phones require harmful mining procedures to harvest rare metals. But increasingly, ecologists and conservation biologists are asking whether we can use technology [...]

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A matter of priorities: Bacteria evolved way to safeguard crucial genetic material, Prof Nick Luscombe publishes in Nature

23 April 2012

Different genes mutate at different rates, in the bacterium E. coli.
Credit: EMBL / I. Martincorena.

Just as banks store away only the most valuable possessions in the most secure safes, cells prioritise which genes they guard most closely, researchers at the European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI) have found. The study, published online today in Nature, shows that bacteria have evolved a mechanism that protects important genes from random mutation, effectively reducing the risk of self-destruction. The findings answer a question that has been under debate for half a century and provide insights into how disease-causing mutations arise and pathogens evolve.

“We discovered that there must be a molecular mechanism that preferentially protects certain areas of the genome over others,” says Nicholas Luscombe, who led the research at EMBL-EBI. “If we can identify the proteins involved and uncover how this works, we will be even closer to understanding how mutations that lead to diseases like cancer can be prevented.”

Read more in EMBL Press Release 22 April 2012 - A matter of priorities


Nick Luscombe

Nick Luscombe

Other links:

Professor Nick Luscombe (EMBL)

Lab website
GEE News regarding Nick Luscombe's appointment in March 2012

University College London (joint appointment)

UCL Genetics Institute, Dept of Genetics, Evolution & Environment, 

University College London, Gower Street, London WC1E 6BT, UK


Cancer Research UK London Research Institute (joint appointment)

44 Lincoln's Inn Fields, London WC2A 3LY, UK


Okinawa Institute of Science & Technology (visiting faculty)

1919-1 Tancha, Onna-son, Kunigami-gun, Okinawa 904-0495, Japan 

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