Anti-Ageing: Health or Beauty?

Tue, 07 Jul 2015 13:52:48 +0000

a guest blog by Jorge I. Castillo-Quan, written for the 2015 Write About Research Competition. If you had not heard of the term anti-ageing you have not noticed spam emails, television advertising, and articles in magazines. The term anti-ageing has definitely permeated our society. Most scientists struggle to explain to their non-scientist friends what their […]

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16 April 2013

GEE/CEE Seminar on mitochondria, hybrid breakdown and the origin of species


"Consequences of rapid mtDNA evolution: compensatory coadaptation, hybrid breakdown and speciation"


Speaker:

Ron Burton, Professor of Marine Biology, Scripps Institution of Oceanography, University of California San Diego
Date & Time:
Wednesday, 17 April at 5pm
Venue: Medical Sciences AV Hill Lecture Theatre (map)
Host: Nick Lane (Ext 31385)


Abstract:

Despite its small size and limited gene content, the rapid evolution of the mitochondrial genome (mtDNA) has significant implications for the evolution of animal populations.  Aerobic metabolism requires all 13 of the mtDNA-encoded proteins in addition to >70 nuclear proteins.  In addition,  ~100 additional nuclear proteins are required for the transcription and translation of the mtDNA and must be imported into the mitochondria.  Consequently, there are many interactions between mtDNA and nucDNA that favor extensive intergenomic coadaptation.  When genetically divergent populations hybridize, coadaptation can be disrupted and lead to mitochondrial dysfunction and reduced fitness (hybrid breakdown). Interpopulation crosses between populations of the copepod Tigriopus californicus provide a good example of this scenario, as hybrid breakdown is due, in large measure, to intergenomic interactions affecting mitochondrial function (manifested in reduced ATP production and increased oxidative damage).  Recent work using transcriptomic analyses of both hybrid breakdown and population adaptation to thermal stress in Tigriopus will also be briefly discussed.

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