We are manually capturing protein-protein interaction (PPI) experimental data from the cardiovascular-related literature and submitting this to the IntAct public dataset at EBI. This data is then incorporated into the IMEx Consortium dataset. These annotations will contribute to the expansion and development of the existing PPI network and advance our knowledge about protein interactions within the cardiovascular system.

We are currently focusing on re-annotating papers which we had previously identified as including PPI experimental data, during the previous cardiovascular GO annotation Initiative. For example, the interaction between DVL1 and DVL3 described by Kishida et al, 1999, was captured as a GO annotation in 2008. This interaction is now in the IntAct and IMEx datasets and can therefore be included in software creating PPI networks. Detailed information about the annotation process can be found here.

Current PPI annotation projects:

  • Cardiac conduction (Ruth)
  • Lipid traits (Nancy, Mila)
  • Telomers (Nancy)
  • Wnt signalling (Anna)
  • Heart development (Mila)

Annotation progress can be viewed using the graph tab in the IntAct cardiac dataset pageĀ 

Page last modified on 04 jul 14 12:37

The work of the Cardiovascular Gene Annotation group is supported by British Heart Foundation grant RG/13/5/30112. The work of the Neurological Gene Annotation group is supported by Parkinson's UK grant G-1307.