Gene Ontology Proteins

Selection of TERT GO annotations

We are manually annotating proteins thought or known to play a role in cardiovascular systems through the application of Gene Ontology (GO) terms. Manual annotation is a time-consuming process but provides highly descriptive annotations. The UCL team in general takes a process-focused approach when prioritising which gene products to annotate. The advantage of a process-focused annotation approach is that it gives the curators time to fully understand the biological area they are annotating and consequently provide highly descriptive annotations. In addition, the curators request very descriptive GO terms, because they are keen to improve the annotation of this domain. Finally each paper is fully annotated, which may not happen when curators are taking a gene product focused approach.

Current GO annotation projects:

  • Cardiac conduction (Ruth)
  • Telomerase and telomere-related proteins (Nancy)
  • Proteins involved in miRNA processing (Rachael)
  • Folic acid metabolism (Hadil Alrohaif, MSc project student)
  • Hereditary hemochromatosis (Klaus Mitchell, MSc project student)

Previous GO annotation projects:

Page last modified on 28 jul 15 13:33

The work of the Cardiovascular Gene Annotation group is supported by British Heart Foundation grant RG/13/5/30112. The work of the Neurological Gene Annotation group is supported by Parkinson's UK grant G-1307. The Functional Gene Annotation team is supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre.