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The work of the Cardiovascular Gene Annotation group is supported by British Heart Foundation grant RG/13/5/30112. The work of the Neurological Gene Annotation group is supported by Alzheimer's Research UK grant ARUK-NSG2016-13. The Functional Gene Annotation team is supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre.
New paper in Circulation
We are pleased to announce publication of a new paper "Improving Interpretation of Cardiac Phenotypes and Enhancing Discovery With Expanded Knowledge in the Gene Ontology". This YouTube video summarises our paper and explains how we have created a computational resource to facilitate genetic studies of cardiac physiology by integrating literature curation with attention to an improved and expanded ontological representation of heart processes in the Gene Ontology. Addition of new GO terms describing cardiac muscle cell action potential, electrical coupling, and the transmission of the electrical impulse from the sinoatrial node to the ventricles can help to identify candidate genes associated with arrhythmic disease risk loci.
Cardiovascular Gene Annotation Newsletter has just been published
In the February issue of the cardiovascular newsletter, we congratulate Nancy and Rachael on becoming Fellows of the Higher Education Academy. Also, Nancy added 357 interactions to the IntAct database and started work with them on the Dark Space Project (DSP). In addition, we thank Vanessa for contributing 1000 new GO annotations, many of which describe the role of microRNAs in angiogenesis, and we welcome this year’s MSc student, Hao Chen. See the newsletter for more details!
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