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Gene Ontology microRNAs

Since January 2015 we have been using the Gene Ontology (GO) to describe the biological roles of microRNAs (miRNAs). Our aim is to to curate miRNAs involved in cardiovascular development and related processes. Alongside this we have curated the roles of the key human proteins involved in miRNA processing, such as Drosha and Dicer.

The RNA annotations are available in the regular GOA release files and AmiGO2.            Example: View the annotations associated with hsa-miR-133a

Any queries about the miRNA project should be directed to Rachael Huntley.

Current annotation projects

  • BHF-funded research papers (Rachael)
  • Cardiac regeneration (Rachael and Barbara)
  • Aortic aneurysm (Zara Umrao, MSc project student)

Past annotation projects

  • Cardiac conduction (Rachael)

How we annotate miRNAs

miRNA annotation

miRNA curation guidelines

As part of this project we have drawn up miRNA curation guidelines, in consultation with the Gene Ontology Consortium and experts in miRNA research, which cover how a curator should translate into GO annotations the common experimental assays used to investigate miRNA function, including how to annotate experimentally verified targets of miRNAs as well as the physiological effects that silencing has on the cell or organism.

View the miRNA curation guidelines