Gene Ontology microRNAs

News April 2015

We are pleased to announce our first release of Gene Ontology (GO) annotations describing the biological roles of microRNAs (miRNAs).

Previously, we have concentrated on providing annotations to proteins and, more recently, macromolecular complexes. In November we began a project to curate miRNAs that are involved with cardiovascular development and related processes. In conjunction with this effort we have curated the roles of the key human proteins that are involved in miRNA processing, such as Drosha and Dicer.

The RNA annotations are available in the regular GOA release files (available from ftp://ftp.ebi.ac.uk/pub/databases/GO/goa/UNIPROT/) and in AmiGO2. For example see the annotations associated with hsa-miR-133a. These annotations will shortly be available in the new version of QuickGO.

There are currently around 80 annotations provided by the UCL team to RNAcentral identifiers, but this is due to increase substantially as the project progresses.

Furthermore, we have circulated microRNA annotation guidelines to other GO Consortium members, to ensure a consistent annotation approach for microRNAs. These have been generally accepted and will soon be circulated to microRNA experts.

Please address any queries to Rachael Huntley, the lead biocurator for this project.

Decision Tree of the GO terms and annotation extensions used for capturing targets of miRNAs

Decision Tree of the GO terms and annotation extensions used for capturing targets of miRNAs.

The types of evidence are listed in the blue boxes. The green boxes summarise the data supporting the data available and the annotations that can therefore be generated. The pink boxes indicate that the published descriptions of an miRNA does not meet the GOC guideline criteria will not be captured.

A reporter assay, or a Co-IP plus an assay demonstrating an effect of the miRNA on mRNA levels, is sufficient to classify a target as “validated binding”, additional evidence that the target is predicted for the miRNA does not affect the annotation given therefore this option is not shown. Author justification means the author indicates why this mRNA is an expected target or shows an effect on an expected downstream process.

Page last modified on 30 apr 15 16:19

The work of the Cardiovascular Gene Annotation group is supported by British Heart Foundation grant RG/13/5/30112. The work of the Neurological Gene Annotation group is supported by Parkinson's UK grant G-1307. The Functional Gene Annotation team is supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre.