Creation of annotation data is obviously a major activity for the biocurators. However, biocurators at UCL are involved in a wide range of activities:
Involves creating the annotations; where gene products such as proteins and microRNAs are associated with ontology terms. However, the ontology terms, as well as the relationships linking them together, are constantly changing as the terms are improved by the curators.
A complex process involving the porcess of creating, improving, expanding, limiting or removing the ontology terms and their relationships so as to reflect the most recent literature and scientific evidence. The continual development of the ontology ensures that the annotations are accurate, up-to-date and highly detailed.
The UCL-annotation team discusses the annotation project with expert
scientists who act as advisors to ensure the appropriate annotation focus is being
Following an annotation approach that is in line with the established procedures for the association of Gene Ontology (GO) terms with gene products and the creation of molecular inlcuding protein-protein interaction (PPI) data is essential. The UCL-biocurators contribute to this scientific effort by participating in discussions concerning updates to the guidelines; for example by presenting case studies from their annotation projects.
The BHF-UCL team seek and have succeeded in securing the input of expert researchers in the field for each annotation project.
UCL biocurators attend national and international meetings & conferences in order to keep in touch with the latest developments in the field as well as to seek the input of expert researchers.
We have several volunteers who became interested in gene ontology and annotations through our workshops over the years. They continue to submit annotations to the GO database.
Page last modified on 03 aug 15 15:17
The work of the Cardiovascular Gene Annotation group is supported by British Heart Foundation grant RG/13/5/30112. The work of the Neurological Gene Annotation group is supported by Parkinson's UK grant G-1307. The Functional Gene Annotation team is supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre.