Scleroderma lung fibroblasts

Research

Pioneering research is central to the FLARRE Consortium. Click on the tabs to discover more about what we do - Research with FLARRE.

Inflammation

  • Role of the innate and adaptive immune system in tissue injury
  • Use of Biologics and SMI  in the treatment of autoimmune diseases
  • Genomic studies and gene regulation in juvenile arthritis and multisystem familial inflammatory disease
  • B-cell signalling and autoimmunity
  • Morphogen signalling in determining the fate of T-cell differentiation
  • Monocyte/Macrphage plasticity and differentiation programmes in inflammation
  • Human T-cell differentiation and longevity - loss of immunity in ageing humans
  • Molecular and biochemical pathways that regulate the resolution of acute immune reactions and inflammation
  • Regulation of lymphocyte differentiation based on the cell environment

Tissue Repair and Scarring

  • Tissue repair process mechanisms
  • Role of connexins in chronic wound healing and fibrosis - reduce scarring and inflammation
  • Biophysical and functional properties of vascular potassium channels - roles in sepsis, vascular remodelling and pulmonary hypertension
  • Calcineurin and its role in smooth muscle proliferation
  • Regeneration of skeletal muscle - identification of progenitor cell types and their genetic manipulation

Fibrosis

  • Pathways leading to chronic kidney disease and renal fibrosis
  • Cellular and molecular mechanisms and pathogenesis of fibrosis in skin, connective tissue, kidney, liver, intestine and eye
  • Role of TGF beta superfamily in the initiation and progression of fibrosis and pulmonary hypertension
  • Role of fibroblast progenitor populations in fibrosis
  • Genetic and epigenetic mechanisms of scarring and fibrosis
  • The role of the microenvironment and cell-matrix interactions
  • Signal transduction and morphogen pathways in tissue remodeling
  • Delineating procoagulant signalling pathways leading to ALI and COPD
  • Myofibroblast differentiation and cell interactions in the pathogenesis of fibrosis
  • Pathogenesis of scleroderma
  • Cirrhosis, portal hypertension and alcohol- and lipotoxicity-induced liver fibrosis
  • Eye infections, scarring conjunctivitis and fibrotic blinding diseases
  • ECM proteomic and bioinformatic studies of fibrosis

Translational Approaches

  • Development and use of in vivo models of human disease
  • Design and synthesis of small molecule drug candidates and molecular probes for epigenetic proteins
  • Liver regenerative medicine
  • New therapies for rheumatoid arthritis and other autoimmune rheumatic diseases - defining the cellular and molecular mechanisms that switch off inflammation
  • Diagnostic and prognostic tools for determining the rate of progression of advanced chronic liver disease

Page last modified on 09 sep 13 14:40