Key Publications

Prominent papers published 2013-2015 are highlighted in the box below. For a comprehensive list of publications, follow the links to a researcher's IRIS Profile.

  1. pDC and B regs. Mauri C. Immunity.2016 Mar 15;44 (3):683-97. 
  2. Mediators of inflammatory resolution. Gilroy D. Proc Natl Acad Sci USA. 2016 Jun 7; 113 (23):E3240-9. 
  3. Novel metabolic anti-fibrotics. Dart J. JCI Insight. 2016 Aug 4;1(12):e87001.
  4. Anti-TNF and rheumatoid arthritis. Ehrenstein M. J Exp Med. 2016 Jun 27; 213(7):1241-53. 
  5. Research in paediatric rheumatology. Wedderburn L. Nat Rev Rheumatol. 2016 Nov; 12 (11):684-690). 
  6. Optimizing T-cell receptor gene therapy. Blood. Stauss H. 2016 Jun 30; 127 (26):3305-11. 
  1. Satellite cells from dystrophic muscle retain regenerative capacity. Boldrin L, Zammit PS,Morgan JE. Stem Cell Res.2015 Jan;14(1):20-9.
  2. The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity. Furmanski AL, Barbarulo A, Solanki A, Lau CI, Sahni H, Saldana JI, D'Acquisto F, Crompton T. J Cell Sci.2015 Jun 1;128(11):2085-95.
  3. HIF1α allows monocytes to take a breather during sepsis. Gilroy DW, Yona S. Immunity 2015 Mar 17;42(3):397-9.
  4. Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells. Pallett LJ, Gill US, Quaglia A, Sinclair LV, Jover-Cobos M, Schurich A, Singh KP, Thomas N, Das A, Chen A, Fusai G, Bertoletti A, Cantrell DA, Kennedy PT, Davies NA, Haniffa M, Maini MK. Nat Med.2015 Jun;21(6):591-600. 
  5. Virus-specific T lymphocytes home to the skin during natural dengue infection. Rivino L, Kumaran EA, Thein TL, Too CT, Gan VC, Hanson BJ, Wilder-Smith A, Bertoletti A, Gascoigne NR, Lye DC, Leo YS, Akbar AN, Kemeny DM, MacAry PA. Sci Transl Med.2015 Mar 11;7(278):278ra35.
  6. Regulatory B cells: origin, phenotype, and function. Rosser EC, Mauri C. Immunity 2015 Apr 21;42(4):607-12. 
  7. The p38 mitogen-activated protein kinase cascade modulates T helper type 17 differentiation and functionality in multiple sclerosis. Di Mitri D, Sambucci M, Loiarro M, De Bardi M, Volpe E, Cencioni MT, Gasperini C, Centonze D, Sette C, Akbar AN, Borsellino G, Battistini L. Immunology 2015 Oct;146(2):251-63. 
  8. Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension.  Good RB, Gilbane AJ, Trinder SL, Denton CP, Coghlan G, Abraham DJ, Holmes AM. Am J Pathol. 2015 Jul;185(7):1850-8.
  9. The many faces of type I interferon in systemic lupus erythematosus. Mauri C, Menon M. J Clin Invest. 2015 Jul 1;125(7):2562-4.
  10. Failed degradation of JunB contributes to overproduction of type I collagen and development of dermal fibrosis in patients with systemic sclerosis. Ponticos M, Papaioannou I, Xu S, Holmes AM, Khan K, Denton CP, Bou-Gharios G, Abraham DJ. Arthritis Rheumatol. 2015 Jan;67(1):243-53.
  11. Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment. Burgoyne T, Meschede IP, Burden JJ, Bailly M, Seabra MC, Futter CE. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15922-7.
  12. Regulation of neutrophilic inflammation by proteinase-activated receptor 1 during bacterial pulmonary infection. José RJ, Williams AE, Mercer PF, Sulikowski MG, Brown JS, Chambers RC. J Immunol. 2015 Jun 15;194(12):6024-34.
  13. Human corneal stromal stem cells support limbal epithelial cells cultured on RAFT tissue equivalents. Kureshi AK, Dziasko M, Funderburgh JL, Daniels JT. Sci Rep. 2015 Nov 4;5:16186. 
  14. Selexipag for the Treatment of Pulmonary Arterial Hypertension. Sitbon O, Channick R, Chin KM, Frey A, Gaine S, Galiè N, Ghofrani HA, Hoeper MM, Lang IM, Preiss R, Rubin LJ, Di Scala L, Tapson V, Adzerikho I, Liu J, Moiseeva O, Zeng X, Simonneau G, McLaughlin VV; GRIPHON Investigators. N Engl J Med. 2015 Dec 24;373(26):2522-33.
  15. TNFα Regulates SIRT1 Cleavage during Ocular Autoimmune Disease. Gardner PJ, Yazid S, Chu CJ, Copland DA, Adamson P, Dick AD, Calder VL. Am J Pathol. 2015 May;185(5):1324-33.
  1. Recurrent HCV after liver transplantation-mechanisms, assessment and therapy. Joshi D,Pinzani M, Carey I, Agarwal K. Nat Rev Gastroenterol Hepatol. 2014Dec;11(12):710-21.
  2. Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production. Rosser EC, Oleinika K, Tonon S, Doyle R, Bosma A, Carter NA, Harris KA, Jones SA, Klein N, Mauri C. Nat Med. 2014 Nov;20(11):1334-9.
  3. Resolution of acute inflammation bridges the gap between innate and adaptive immunity. Newson J, Stables M, Karra E, Arce-Vargas F, Quezada S, Motwani M, Mack M, Yona S, Audzevich T, Gilroy DW. Blood. 2014 Sep 11;124(11):1748-64.
  4. Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2. O'Brien AJ, Fullerton JN, Massey KA, Auld G, Sewell G, James S, Newson J, Karra E, Winstanley A, Alazawi W, Garcia-Martinez R, Cordoba J, Nicolaou A, Gilroy DW. Nat Med. 2014 May;20(5):518-23. Arthritis Rheumatol. 2014 Oct;66(10):2694-705.
  5. Induced CD8+FoxP3+ Treg cells in rheumatoid arthritis are modulated by p38 phosphorylation and monocytes expressing membrane tumor necrosis factor α and CD86. Ellis SDI, McGovern JL, van Maurik A, Howe D, Ehrenstein MR, Notley CA. 
  6. The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells. Lanna A, Henson SM, Escors D, Akbar AN. Nat Immunol. 2014 Oct;15(10):965-72.
  7. Systemic lupus erythematosus. Lisnevskaia L, Murphy G, Isenberg D. Lancet. 2014 Nov 22;384(9957):1878-88.
  8. Changes in regulation of human monocyte proteins in response to IgG from patients with antiphospholipid syndrome. Ripoll VM, Lambrianides A, Pierangeli SS, Poulton K, Ioannou Y, Heywood WE, Mills K, Latchman DS, Isenberg DA, Rahman A, Giles IP. Blood. 2014 Dec 11;124(25):3808-16.
  9. Interstitial lung disease in connective tissue disease--mechanisms and management. Wells AU, Denton CP. Nat Rev Rheumatol. 2014 Dec;10(12):728-39.
  10. The coming of age of adolescent rheumatology. Eleftheriou D, Isenberg DA, Wedderburn LR, Ioannou Y. Nat Rev Rheumatol. 2014 Mar;10(3):187-93.
  11. Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial. Chataway J, Schuerer N, Alsanousi A, Chan D, MacManus D, Hunter K, Anderson V, Bangham CR, Clegg S, Nielsen C, Fox NC, Wilkie D, Nicholas JM, Calder VL, Greenwood J, Frost C, Nicholas R. Lancet. 2014 Jun 28;383(9936):2213-21.
  1. De Lauretis, A., Sestini, P., Pantelidis, P., Hoyles, R., Hansell, D. M., Goh, N. S., Renzoni, E. A. (2013). Serum interleukin 6 is predictive of early functional decline and mortality in interstitial lung disease associated with systemic sclerosis. J Rheumatol, 40 (4), 435-446.
  2. Griffiths, S. J., Riddell, N. E., Masters, J., Libri, V., Henson, S. M., Wertheimer, A., Akbar, A. N. (2013). Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA. J Immunol, 190 (11), 5363-5372. 
  3. Vukmanovic-Stejic, M., Sandhu, D., Sobande, T. O., Agius, E., Lacy, K. E., Riddell, N., Akbar, A. N. (2013). Varicella zoster-specific CD4+Foxp3+ T cells accumulate after cutaneous antigen challenge in humans. J Immunol, 190 (3), 977-986.
  4. Hoare, M., Shankar, A., Shah, M., Rushbrook, S., Gelson, W., Davies, S., Alexander, G. J. M. (2013). gamma-H2AX+CD8+T lymphocytes cannot respond to IFN-alpha, IL-2 or IL-6 in chronic hepatitis C virus infection. JOURNAL OF HEPATOLOGY, 58 (5), 868-874.
  5. Balasubramaniyan, V., Dhar, D. K., Warner, A. E., Vivien Li, W. Y., Amiri, A. F., Bright, B., Jalan, R. (2013). Importance of Connexin-43 based gap junction in cirrhosis and acute-on-chronic liver failure. J Hepatol, 58 (6), 1194-1200. 
  6. Furmanski, A. L., O'Shaughnessy, R. F., Saldana, J. I., Blundell, M. P., Thrasher, A. J., Sebire, N. J., Crompton, T. (2013). T-cell reconstitution after thymus xenotransplantation induces hair depigmentation and loss. J Invest Dermatol, 133 (5), 1221-1230.
  7. Carter, L. M., Isenberg, D. A., & Ehrenstein, M. R. (2013). Elevated serum B-cell activating factor (BAFF / BLyS) is associated with rising anti-dsDNA antibody levels and flare following B-cell depletion therapy in systemic lupus erythematosus. Arthritis Rheum. doi:10.1002/art.38074.
  8. Calhabeu, F., Hayashi, S., Morgan, J. E., Relaix, F., & Zammit, P. S. (2013). Alveolar rhabdomyosarcoma-associated proteins PAX3/FOXO1A and PAX7/FOXO1A suppress the transcriptional activity of MyoD-target genes in muscle stem cells.ONCOGENE, 32 (5), 651-662.
  9. Boldrin, L., & Morgan, J. E. (2013). Grafting of a single donor myofibre promotes hypertrophy in dystrophic mouse muscle.PLoS One, 8 (1), e54599-?
  10. Berzigotti, A., Seijo, S., Arena, U., Abraldes, J. G., Vizzutti, F., García-Pagán, J. C., Bosch, J. (2013). Elastography, spleen size, and platelet count identify portal hypertension in patients with compensated cirrhosis. Gastroenterology, 144 (1), 102-111.
  11. Arena, U., Platon, M. L., Stasi, C., Moscarella, S., Assarat, A., Bedogni, G., . . . Pinzani, M. (2013). Liver stiffness is influenced by a standardized meal in patients with chronic hepatitis C virus at different stages of fibrotic evolution. Hepatology, 58 (1), 65-72.
  12. Wulffraat, N. M., & Woo, P. (2013). Canakinumab in pediatric rheumatic diseases. EXPERT OPINION ON BIOLOGICAL THERAPY, 13 (4), 615-622. 
  13. Hinks, A., Cobb, J., Marion, M. C., Prahalad, S., Sudman, M., Bowes, J.,  Thompson, S. D. (2013). Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet, 45 (6), 664-669.
  14. Woo, P., & Humphries, S. E. (2013). IL-6 polymorphisms: a useful genetic tool for inflammation research?. JOURNAL OF CLINICAL INVESTIGATION, 123 (4), 1413-1414.
  15. Ter Haar, N., Lachmann, H., Özen, S., Woo, P., Uziel, Y., Modesto, C., aediatric Rheumatology International Trials Organisation (PRINTO) and the Eurofever/Eurotraps Projects. (2013). Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review. Ann Rheum Dis, 72 (5), 678-685.

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