Genetic modification is the modification of genetic material of an organism (either DNA or RNA) using a method that does not occur in nature and where the modification can be replicated and/or transferred to other cells or organisms.
Contained use is any activity in which GMOs are cultured, stored, transported, destroyed, disposed of or used in any other way and for which physical, chemical or biological barriers are used to limit contact with humans or the environment to ensure a high degree of safety.
What do I have to do if I work with genetically modified organisms (GMOs)?
If you carry out any contained use activity with GMOs - this includes genetically modified micro-organisms (GMMs), animals or plants, you must assess the risks to human health and the environment.
All work must be assessed using the online risk assessment tool in RiskNET. This tool also provides the means of approval/authorisation of your assessment by your Departmental Genetic Modification Safety Officer (GMSO), the University's Biological Safety Adviser (UBSA) and UCL's Genetic Modification Safety Committee (GMSC). You cannot start work until your assessment has been approved (including any acknowledgements/consents from HSE if appropriate).
Before you start work - hints and tips
Step 2: Using the RiskNET tool to prepare and submit your assessment
Step 3: Notification to HSE including completing the CU2 (for Class 2 and 3 activities)
Containment and control measures needed for work with GMMs and GMOs