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Tn Number Registry

This website has been set up to designate Tn numbers to researchers publishing details of new transposable elements discovered in bacteria and archaea. Transposable elements are defined as “specific DNA segments that can repeatedly insert into one or more sites in one or more genomes” (Roberts et al., 2008). This definition is modified from that stated in the original nomenclature proposal (Campbell et al., 1979a; 1979b) allowing it to include the many different types of transposable elements discovered since the original proposal was published.

New individual Tn numbers should be given to elements showing < 100% deduced nucleotide sequence similarity to their closest relatives, or to elements that contain novel resistance, virulence, catabolic or other accessory genes, or novel combinations of genes or modules. If functionality is demonstrated (excision, insertion, transposition or transfer) but the entire sequence of the element is not determined the element may still be assigned a Tn number provided the known sequence is sufficiently different from previously determined sequences, as described above. The rules governing the requesting of Tn numbers are summarised in a key below.

It is appreciated that other elements such as integrated or transposable prophage and satellite prophage, group I and II introns, IStrons, inteins, and insertion sequences fit this definition of a transposable element. However, in most cases there is already a coherent nomenclature system in place and any change would cause confusion. If a novel element is found which fails to qualify for an established nomenclature scheme a Tn number should be used.

Key for determining if a Tn number is appropriate. (not appropriate for ISs or non autonomous transposable elements such as integron cassettes or MITEs) (Roberts et al., 2008).

  1. Has excision, insertion, transposition and / or transfer been demonstrated?
    Yes; go to 3
    No; go to 2

  2. Has the entire DNA sequence been determined and the putative ends delineated?a
    Yes; go to 4
    No; go to 6

  3. Is any part of the DNA sequence of the element known?
    Yes; go to 4
    No; go to 6

  4. Is the nucleotide sequence <100% identical to known sequences?
    Yes; go to 7
    No; go to 5

  5. Is synteny conserved over the entire sequence compared to database sequences?
    Yes; got to 6
    No; got to 7

  6. A Tn number is inappropriate at this stage

  7. A Tn number is appropriate

ain the case of composite transposon flanked by IS elements transposition or different insertion sites need to be demonstrated, as it is possible that the majority of these have never transposed.

Roberts AP, Chandler M, Courvalin P, Guédon G, Mullany P, Pembroke T, Rood JI, Smith CJ, Summers AO, Tsuda M, Berg DE. (2008) Revised Nomenclature for Transposable Genetic Elements. Plasmid. 60; 167-173.

Campbell A, Starlinger P, Berg DE, Botstein D, Lederberg EM, Novick RP, Szybalski W. 1979. Nomenclature of transposable elements in prokaryotes. Plasmid. 2:466-73 and Gene 5:197-206

Any feedback and suggestions on this site are welcome (please use the feedback form).

Assigned Tn numbers


Tn Number Name Organization/Address Characteristics Reference Accession Numbers
Tn6000 Dr Adam Roberts UCL Eastman Dental Institute
256 Gray's Inn Road
London
UK
Previously designated EfcTn1 this conjugative transposon confers tetracycline resistance [tet(S)]. It is based on a Tn916-like backbone however the integrase is more related to the integrase of Staphylococcal pathogenicity islands.
Roberts et al.,(2006) Characterization of the Ends and Target Site of a Novel Tetracycline Resistance-Encoding Conjugative Transposon from Enterococcus faecium 664.1H1. Journal of Bacteriology 188:4356-61.
DQ295784 [tet(S)],DQ370177 (left end), DQ370176 (right end).
Tn6001 Dr Sung-Pin Tseng NTU CLS&MB Institute
No. 1, Chang-Te Street
Taipei
Taiwan
  Tseng SP et al.,(2007) Characterization of Tn6001, a Transposon-Like Element Containing the blaVIM-3-harboring Integron In450. Antimicrobial Agents and Chemotherapy. 51(11):4187-90.
EF138817
Tn6002 Dr Philip Warburton UCL Eastman Dental Institute
256 Gray's Inn Road
London
UK
Tn916-like element with a 2.8kb erythromycin resistance encoding insert within orf20.
Warburton PJ et al.,(2007) Demonstration of in vivo transfer of doxycycline resistance mediated by a novel transposon. Journal of Antimicrobial Chemotherapy. 60(5):973-80
AY898750
Tn6003 Prof Maria Pia Montanari Institute of Microbiology and Biomedical
Polytechnic University of Marche Medical
Ancona
Italy
Tn6003; (4225 bp) contains an erm(B) (lacking the stop codon) with its peptide leader; an aminoglycoside-streptothricin resistance cluster (aadE-sat4-aphA-3 genes) (100% homology, save for a deletion of 511 nucletides in aadE); and an ORF identical to orf47 of plasmid pRE25 of E. faecalis. This element has inserted into Tn6002.
Cochetti et al.,(2007) New Tn916-related elements causing erm(B)-mediated erythromycin resistance in tetracycline susceptable pneumococci. Journal of Antimicrobial Chemotherapy. 60(1):127-31
AM410044
Tn6004 Dr Elisabetta Mantengoli Università degli studi di siena
Policlinico le scotte, viale bracci 16
Siena
Italy
Tn3-like transposon containing an IS26 insertion in tnpR.
Endimiani A et al., (2007). Spread in an Italian Hospital of a clonal Acinetobacter baumannii Strain Producing the TEM-92 Extended-Spectrum Beta-Lactamase. Antimicrobial Agents and Chemotherapy. 51(6):2211-2214.
 
Tn6005 Dr Maurizio Labbate Macquaarie University
Balaclava Rd
North Ryde
Sydney
NSW
Australia
  Labbate et al., (2008). A class 1 integron present in a human commensal has a hybrid transposition module compared to Tn402: evidence of interaction with mobile DNA from natural environments. Journal of Bacteriology. Epub ahead of print
 
Tn6006 Dr Maurizio Labbate Macquaarie University
Balaclava Rd
North Ryde
Sydney
NSW
Australia
  As for Tn6005
 
Tn6007 Dr Maurizio Labbate Macquaarie University
Balaclava Rd
North Ryde
Sydney
NSW
Australia
  As for Tn6005
 
Tn6008 Dr Maurizio Labbate Macquaarie University
Balaclava Rd
North Ryde
Sydney
NSW
Australia
  As for Tn6005
 
Tn6009 Dr Olusegun Soge University of Washington
Department of Pathobiology
Box 357238
Seattle
WA
USA
Tn916 element linked with a Staphylococcus aureus mer operon
Soge et al., (2008). A novel transposon, Tn6009, composed of a Tn916 element linked with a Staphylococcus aureus mer operon. Journal of Antimicrobial Chemotherapy. Epub ahead of print.
EU239355, EU399632
Tn6010 Mr Anders Norman University of Copenhagen
Sølvgade 83H
Copenhagen
Denmark
Composite transposon from E. coli
Norman et al., (2008) Nucleotide sequence of pOLA52: A conjugative IncX1 plasmid from Escherichia coli which enables biofilm formation and multidrug efflux. Plasmid 60:59-74.
EU370913
Tn6011 Mr Anders Norman University of Copenhagen
Sølvgade 83H
Copenhagen
Denmark
Composite transposon from E. coli
Norman et al., (2008) Nucleotide sequence of pOLA52: A conjugative IncX1 plasmid from Escherichia coli which enables biofilm formation and multidrug efflux. Plasmid 60:59-74.
EU370913
Tn6012 Dr Teruyo Ito Juntendo University
Hongo 2-1-1
Bunkyyo-ku
Tokyo
Japan
Putative conjugative transposon from Staphylococcus aureus.
Han et al., (2009)Identification of a novel variant of staphylococcal cassette chromosome mec, type II.5, and Its truncated form by insertion of putative conjugative transposon Tn6012. Antimicrobial Aents and Chemotherapy. 53, 2616-9
AB435014
Tn6013 Dr D. Ashley Robinson New York Medical College
Microbiology and Immunology
Valhalla
NY
USA
Integrative conjugative element from Staphylococcus aureus. Designated ICE6013
Smyth and Robinson, 2009, Integrative and sequence characteristics of a novel genetic element, ICE6013, in Staphylococcus aureus. Journal of Bacteriology. 191: 5964-75
FJ231270
Tn6014 Miss Lisbeth de Vries National Food Institute
DTU
Bülowsvej 27
Copenhagen V
Denmark
Tn5801-like transposon shown to transfer horizontally from one S. aureus into the S. aureus recipient RN4220F
J Antimicrob Chemother. 2009 Sep; 64 (3): 490-500
EU918655
Tn6015 Dr Richard Eaton Agricultural Research Service, USDA
1100 Robert E. Lee Blvd.
Southern Regional Research Center
New Orleans
Louisiana
USA
     
Tn6016 Prof Paul Roy Université Laval
Infectious Diseases Res. Ctr.
2705, boul. Laurier, Suite RC-709
Québec
QC
Canada
     
Tn6017 Prof Paul Roy Université Laval
Infectious Diseases Res. Ctr.
2705, boul. Laurier, Suite RC-709
Québec
QC
Canada
     
Tn6018 Ms Virginia Post The University of Sydney
Biochemistry Building G08
Sydney
NSW
Australia
  Post and Hall. (2009) AbaR5, a large multiple-antibiotic resistance region found in Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy. 53:2667-2671
FJ172370
Tn6019 Ms Virginia Post The University of Sydney
Biochemistry Building G08
Sydney
NSW
Australia
     
Tn6020 Ms Virginia Post The University of Sydney
Biochemistry Building G08
Sydney
NSW
Australia
  Post and Hall. (2009) AbaR5, a large multiple-antibiotic resistance region found in Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy. 53:2667-2671
FJ172370
Tn6021 Ms Virginia Post The University of Sydney
Biochemistry Building G08
Sydney
NSW
Australia
     
Tn6022 Ms Virginia Post The University of Sydney
Biochemistry Building G08
Sydney
NSW
Australia
     
Tn6023 Ms Virginia Post The University of Sydney
Biochemistry Building G08
Sydney
NSW
Australia
     
Tn6024 Ms Virginia Post The University of Sydney
Biochemistry Building G08
Sydney
NSW
Australia
     
Tn6025 Ms Virginia Post The University of Sydney
Biochemistry Building G08
Sydney
NSW
Australia
     
Tn6026 Ms Virginia Post The University of Sydney
Biochemistry Building G08
Sydney
NSW
Australia
     
Tn6027 Ms Virginia Post The University of Sydney
Biochemistry Building G08
Sydney
NSW
Australia
     
Tn6028 Ms Virginia Post The University of Sydney
Biochemistry Building G08
Sydney
NSW
Australia
     
Tn6029 Ms Virginia Post The University of Sydney
Biochemistry Building G08
Sydney
NSW
Australia
     
Tn6030 Dr Hiroyuki Arai Dept. of Biotechnology, Univ. of Tokyo
Yayoi 1-1-1
Bunkyo-ku
Tokyo
Japan
     
Tn6031 Dr Timothy LaPara University of Minnesota
500 Pillsbury Drive SE
Minneapolis
MN
USA
A mobilizable transposon-like element containing tet(X) sharing organization features and genes with CTnDOT from Bacteroides spp.
Ghosh et al. (2009) Sphingobacterium sp. strain PM2-P1-29 harbours a functional tet(X) gene encoding for the degradation of tetracycline. Journal of Applied Microbiology 106:1336-1342.
EU864422
Tn6032 Dr Hikaru Suenaga AIST
Central 6, 1-1-1 Higashi,
Tsukuba
Japan
     
Tn6033 Mr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6034 Mr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6035 Mr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6036 Mr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6037 Mr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6038 Mr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6039 Mr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6040 Mr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6041 Mr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6042 Mr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6043 Mr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6044 Mr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6045 Ms Sae Tsubakishita Juntendo university
2-1-1 Hongo
Bunkyo-ku
Tokyo
Japan
     
Tn6046 Ms Sae Tsubakishita Juntendo university
2-1-1 Hongo
Bunkyo-ku
Tokyo
Japan
     
Tn6047 Ms Sae Tsubakishita Juntendo university
2-1-1 Hongo
Bunkyo-ku
Tokyo
Japan
     
Tn6048 Dr Rob Van Houdt Unit for Microbiology, SCK-CEN
Boeretang 200
Mol
Belgium
     
Tn6049 Dr Rob Van Houdt Unit for Microbiology, SCK-CEN
Boeretang 200
Mol
Belgium
     
Tn6050 Dr Rob Van Houdt Unit for Microbiology, SCK-CEN
Boeretang 200
Mol
Belgium
     
Tn6051 Dr Rob Van Houdt Unit for Microbiology, SCK-CEN
Boeretang 200
Mol
Belgium
     
Tn6052 Dr Rob Van Houdt Unit for Microbiology, SCK-CEN
Boeretang 200
Mol
Belgium
     
Tn6053 Dr Rob Van Houdt Unit for Microbiology, SCK-CEN
Boeretang 200
Mol
Belgium
     
Tn6054 Dr Rob Van Houdt Unit for Microbiology, SCK-CEN
Boeretang 200
Mol
Belgium
     
Tn6055 Dr Rob Van Houdt Unit for Microbiology, SCK-CEN
Boeretang 200
Mol
Belgium
     
Tn6056 Dr Rob Van Houdt Unit for Microbiology, SCK-CEN
Boeretang 200
Mol
Belgium
     
Tn6057 Dr Rob Van Houdt Unit for Microbiology, SCK-CEN
Boeretang 200
Mol
Belgium
     
Tn6058 Dr Marina Mingoia Department of Biomedical Sciences
via Tronto 10/A
Ancona
Ancona
Italy
     
Tn6059 Dr Emily Tili Department of Biomedical Sciences
via Tronto 10/A
Ancona
Ancona
Italy
     
Tn6060 Dr Piklu Roy Chowdhury University of Technology, Sydney
Institute for the Biotechnology of Infectious Dis
Faculty of Science, City Campus, Broadway
Sydney
NSW
Australia
     
Tn6061 Mr Sebastien Coyne Institut Pasteur
Unité des Agents Antibactériens
25-28 rue du Docteur Roux
Paris
France
     
Tn6062 Mr Minh-Duy Phan The Wellcome Trust Sanger Institute
Wellcome Genome Campus
Hinxton
Cambridge
United Kingdom
     
Tn6063 Dr Jaroslaw Krol University of Idaho
Department of Biological Sciences
Life Science Building 252
Moscow
Idaho
USA
     
Tn6064 Dr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6065 Dr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6066 Dr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6067 Dr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6068 Dr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6069 Dr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6070 Dr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6071 Dr Michael Ryan University of Limerick
Department of Chemical and Environmental Sciences
Castletroy
Limerick
Ireland
     
Tn6072 Dr Liang Chen PHRI-NJMS, UMDNJ
225 Warren St
W210M
Newark
NJ
Unite States
     
Tn6073 Mr Michael Brouwer UCL Eastman Dental Institute
256 Gray's Inn Road
London
UK
     
Tn6074 Dr Helena Seth-Smith Wellcome Trust Sanger Insitute
Hinxton
Cambridge
UK
     
Tn6075 Dr Helena Seth-Smith Wellcome Trust Sanger Insitute
Hinxton
Cambridge
UK
     
Tn6076 Dr Helena Seth-Smith Wellcome Trust Sanger Insitute
Hinxton
Cambridge
UK
     
Tn6077 Dr Helena Seth-Smith Wellcome Trust Sanger Insitute
Hinxton
Cambridge
UK
     

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Credits

This site was designed by Sarah Jancich (UCL) and is maintained by Karen Widdowson (EDI, UCL). The database is administered and updated by Adam Roberts (EDI, UCL).

Disclaimer

The Eastman Dental Institute has taken all reasonable care to ensure this page was accurate on the stated date of publication or last modification. The Eastman Dental Institute takes no responsibility for the consequences of error or for any loss or damage suffered by users of any of the information published on any of these pages, and such information does not form any basis of a contract with readers or users of it.

It is in the nature of Web sites, many of which are experimental or constantly changing, that information published may be for test purposes only, may be out of date, or may be the personal opinion of the author. Readers should verify information gained from the Web with the appropriate Eastman Dental Institute authorities before relying on it.

 
This page was last modified 09 Nov 2009 by Adam Roberts
 

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