Research finding
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Lead researchers
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Main publications in
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Established that periodontitis increases risks of arteriosclerosis and cardiovascular disease, risks being determined genetically through pro-inflammatory cytokine polymorphisms
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D'Aiuto, Nibali
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New England Journal of Medicine
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Elucidated that infection in periodontitis is associated with decrease in serum inflammatory markers
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D'Aiuto, Nibali
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Journal of Dental Research
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Elucidated key mechanisms in Mycobacterium tuberculosis virulence
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Henderson
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Nature Structural and Molecular Biology, Journal of Biological Chemistry
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Identified novel virulence factors of cariogenic bacteria and important health care-associated pathogens
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Allan
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Journal of Bacteriology, Molecular Microbiology
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Sequenced complete genome of hospital antimicrobial-resistant bacterium Clostridium difficile, and enhanced development of relevant molecular tools
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Mullany, Roberts A
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Nature Genetics, Journal of Bacteriology
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Established high frequency of orofacial antimicrobial-resistant organisms in antimicrobial-naïve individuals
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Mullany
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Antimicrobial Agents & Chemotherapy, Journal of Antimicrobial Chemotherapy
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Determined molecular basis of spread of antimicrobial resistance by conjugative transposons
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Mullany, Roberts A
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Antimicrobial Agents & Chemotherapy, Journal of Bacteriology
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Established high frequency of orofacial antimicrobial-resistant organisms in antimicrobial-naïve individuals
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Wilson, Spratt, Mullany
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Antimicrobial Agents & Chemotherapy, Journal of Antimicrobial Chemotherapy
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Determined molecular basis of spread of antimicrobial resistance by conjugative transposons
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Mullany, Roberts A
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Antimicrobial Agents & Chemotherapy, Journal of Bacteriology
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Developed novel targeted photosensitisers to selectively kill orofacial pathogens and hospital-acquired infections e.g. MRSA (meticillin-resistant Staphylococcus aureus)
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Wilson, Nair
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Antimicrobial Agents & Chemotherapy, Journal of Antimicrobial Chemotherapy
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Elucidated interactions of staphylococci with human cells
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Nair, Henderson
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Infection and Immunity
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Established mouth as important site of human herpesvirus 8 (HHV-8) persistence
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Porter, Scully
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Journal of Infectious Diseases
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Established that salivary antibodies to HHV-8 can influence replication of HHV-8, and in turn, HIV
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Porter, Scully
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AIDS
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Analysed potential of novel light curable antimicrobial dental composite restoration materials to prevent bacterial microleakage
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Gulabivala, Pratten, Spratt
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Biomaterials
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Reported first orofacial flora metagenomic study in literature
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Mullany, Wilson, Spratt
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Antimicrobial Agents & Chemotherapy
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Evaluated effectiveness of protocols for field decontamination before bacterial sampling of root canals
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Gulabivala, Ng, Spratt
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Journal of Endodontics
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Identified and characterised virulence factors of orofacial bacteria central to periodontal disease and caries
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Henderson, Nair,
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Infection and Immunity
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Modelled shifts in orofacial bacterial populations associated with health or disease
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Spratt, Pratten, Petrie
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Applied and Environmental Microbiology, Journal of Clinical Microbiology
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Developed in vitro models of development and regression of gingivitis, and susceptibility of plaque, caries and periodontal disease communities to novel antimicrobials
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Pratten, Spratt
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Applied and Environmental Microbiology
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Cumulative meta-analysis in periodontology
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Moles, Needleman
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Journal of Dental Research
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