Dan Jagger's Lab
Dr Dan Jagger is a Lecturer in Auditory Cell Physiology. He studies mechanisms of cochlear homeostasis and sensory transduction, and the cellular basis of hearing loss in ciliary diseases.
I am a physiologist with a research history in auditory cell electrophysiology. Following a PhD at the University of Bristol, I went to New Zealand to work in the lab of Gary Housley at the University of Auckland. Whilst there, I carried out research into the development of electrical signaling by type I spiral ganglion neurons (SGN; afferent neurons innervating inner hair cells), including the role of purinergic neurotransmission and K+ channels. During this project I developed a novel slice preparation of the neonatal cochlea, and this technique enabled us to make the first patch clamp recordings from type II SGN (afferent neurons innervating outer hair cells). Significantly, this work demonstrated that these cells have membrane properties which are distinct to those of type I cells. Soon after returning to UCL in 2002 I was successful in being awarded a Royal Society University Research Fellowship. During this fellowship I worked closely with Andy Forge at the Ear Institute to study the role of gap junctions in the sensory epithelium of the cochlea.
Current research in my lab falls into 3 distinct areas:
- Mechanisms of K+ homeostasis in the inner ear
- The pharmacology of SGN ion channels
- The role of ciliary genes in the development and maintenance of hearing
Page last modified on 08 dec 11 10:45