Ear Talks

Welcome to the Ear Institute's seminar calendar. We aim to keep this calendar as up to date as possible so please check back regularly for details of more confirmed Ear Talks.

30 July, 2014 - Lgr5+ stem cells in epithelial renewal and cancer

Time: 17:30:00 - 18:30:00

Organised by UCL Ear Institute

The availability of robust cell-surface markers for identifying and isolating adult stem cells is essential for studying both their normal in-vivo function during tissue renewal and for evaluating their contribution to cancer. We have shown Lgr5, a Wnt target gene expressing a 7-TM receptor that functions as facultative component of the Wnt receptor complex, to selectively mark stem cells in a range of rapidly renewing tissues, including the small intestine, colon, stomach, hair follicle, ovary and developing kidney. Multicolor lineage tracing employing the stem cell-specific Lgr5-CreERT2 line has been used to further dissect how these adult stem cell pools maintain tissue homeostasis and contribute to tissue repair following damage. Targeted in-vivo mutation of the Lgr5+ve adult stem cell pools using the same Lgr5-CreERT2 model has been used to determine the contribution of stem cells to tumor initiation and progression in the gut. A summary of this work will be presented here.

Location: Main Lecture Theatre, UCL Ear Institute, 332 Grays Inn Road, London, WC1X 8EE

Contact: Anne Oliphant

Email: a.oliphant@ucl.ac.uk


Types of seminar

We have several seminars/discussion groups which run regularly, these are:

  • External Seminars: Guest speakers from other institutions around the world are invited to speak about recent breakthroughs they've made in hearing research. (Takes place every third Thursday at 1pm in the CAR seminar room)
  • Work in Progress (WIP) Seminars: These reports are a chance for members of the Ear Institute to catch up on any exciting new developments that other members are currently working on. (Takes place every third Thursday at 1pm in the CAR seminar room)
  • Grand Rounds: Clinical interest seminars which take place every Wednesday morning in the RNTNEH
  • Cochlear Nonlinear Processing Interest Group: A discussion group for people with research interests in the interpretation of physiological and psychophysical estimates of nonlinear processing at the peripheral level of the auditory system. (These take place roughly every 2 - 3 weeks) (hosted by Ifat and Torsten)
  • Audiology Seminars: Guest speakers from the Ear Institute and other institutions are invited to speak about the important topics affecting clinical audiology. (Takes place on the first Tuesday of every month during term time)
  • Auditory Central Nervous System (CNS) Journal Club: Each week a member of the Institute presents a short summary of their current research followed by a presentation on any topic related to the auditory brain, be it a journal article, review of the state of the literature, or an in-depth discussion of their own work. (Takes place every Tuesday at 10:30)
  • Cochlear Implant group: takes place bimonthly (every two months) for people interested in clinical research into Cochlear Implantation

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