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Heightened activity between the emotional and auditory parts of the brain explains why the sound of chalk on a blackboard, or a knife on a bottle, is so unpleasant.

The total number of papers, reports and PhD dissertations downloaded from UCL Discovery, the university’s Open Access repository, surpassed 2,000,000 during September 2012.

Mexiletine, a decades-old drug previously used to treat abnormal heart rhythms, has been used to alleviate the symptoms of patients with nondystrophic myotonias (NDMs), rare diseases that affect the skeletal muscle and cause functionally limiting stiffness and pain.