Dr. Will Fletcher
Will obtained the level of PhD with his work on Computational statistics in molecular phylogenetics. (Supervisors: Prof. Ziheng Yang and Dr. Hilde Wilkinson-Herbots). About his research, Will notes that:
advances have lead to the rapid accumulation of vast amounts of
molecular biological data which researchers use to investigate
evolution. Many methods aid researchers by aligning molecular sequences
from different species, and then estimating evolutionary parameters and
relationships from this aligned data. Assessing the efficacy of these
procedures is difficult because true evolutionary relatedness
(phylogenetics) and exact values for evolutionary parameters are rarely
known with any certainty. Thus testing computational methods with
synthetic data, produced under realistic conditions, is invaluable.
Evolution is known to occur by the processes of substitution, insertion and deletion. However, the vast majority of computer programs only simulate evolution by substitution and with models that do not change. My PhD is centred on deriving a new dynamic mathematical model of evolution that allows insertions and deletions, in addition to substitutions, and creating a computer program to implement simulations under this model."
Will's Webpage: http://abacus.gene.ucl.ac.uk/will
Page last modified on 06 aug 10 14:41