dr vivek mudera

Contacts
  • Dr
  • Vivek
  • Mudera
  • Dr Vivek Mudera
  • Tel: 00 44 208 909 5634
  • Ex: 020 8909 5634
  • Fax: 00 44 208 954 8560
  • v.mudera@ucl.ac.uk
  • Website
  • https://iris.ucl.ac.uk/iris/extResource/image/01/VMUDE06
  • 1997-07-01
Address
  • 1362
  • Institute of Orthopaedics and Musculoskeletal Sciences, RNOH
  • Brockley Hill
  • Stanmore
  • Middlesex
  • HA7 4LP
Joined UCL
  • 1997-07-01

Research Summary

1) Investigate and test mechanisms for spatial orientation and effect of mechanical cues on cellular responses in 3D with applications in bioreactor technology 2) Investigate and identify cell sources, (stem cells, dermal fibroblasts, tendon fibroblasts and myoblasts) for mechanical and spatial cue responses. 3) Testing tissue engineered constructs in in vivo models specially developed using measurable outcomes. 4)Musculoskeletal engineering: 1) Mechanism's for directing cell differentiation in 3D models of tissue constructs 2) Cell sourcing, using mechanical cues and monitoring through mechano-responsive genes in tissue engineered tendon, skin and muscle constructs 3) Identification of molecular and cellular markers which respond to defined mechanical cues. 4) Mesenchymal stem cells with applications in Musculoskeletal Engineering. 5)Wound Healing: The role of specific cell migration during flexor tendon healing and formation of adhesions, prevention of adhesion formation using protein blockers to inhibit cell migration. Identification of cellular mechanisms in Dupuytren's Contracture and Frozen Shoulder.
Research Activities
  • 3245
  • Bone plug tissue engineering
  • 768
  • Musculoskeletal Engineering
  • 843
  • Regeneration and repair of soft tissue inc. mucosa and skeletal muscle
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Additional Information
  • 3D cell culture
  • 3D culture
  • Antibody assays
  • Bionanotechnology
  • Bioreactors
  • Cell biomechanics
  • Cell culture
  • Cell motility
  • Cell tracking
  • Confocal microscopy
  • Cytomechanical assays
  • Cytomechanics
  • Differentiation
  • Dupuytren's Disease
  • ELISA
  • Electron Microscopy
  • Electrophoresis techniques
  • Extracellular matrix
  • Fibroblast
  • Fibrosis
  • Fluorescence microscopy techniques
  • Gene expression
  • Gene expression profiling - tissue level
  • Histology
  • Human cell culture
  • Hypoxia
  • Image analysis
  • Immunohistochemistry
  • Implants
  • In vitro assays of cell function
  • In vivo models
  • Inflammation
  • Mechanical stress
  • Microscopy
  • Models of disease
  • Musculoskeletal Engineering
  • Nanoparticles
  • Nanotechnology
  • Neuromuscular junction
  • Oxygen
  • Post-surgical Adhesions
  • Primary Frozen Shoulder
  • QPCR
  • Regeneration
  • Repair
  • Stem cells
  • TGF-beta
  • Time-lapse imaging
  • Tissue contraction
  • Tissue engineering
  • effect of mechanics and stiffness on spatial cellular responses in 3D
Collaborators
  • PMGBO58
  • prof pierre-marc bouloux
  • UCHEE56
  • dr umber cheema
  • GJELL65
  • dr gavin jell
  • MPLEW03
  • prof mark lewis
  • SFEDE79
  • dr stefano fedele