UCL CENTRE FOR MATERIALS RESEARCH

Research Summary

Our work focusses on the problem of apical periodontitis and its treatment outcome (including healing and tooth survival). We have adopted a translational model of research designed to improve the outcomes of endodontic treatment procedures by using a systematic approach to synthesise clinical outcomes data to inform clinical practice, clinical trial design and formulation of hypotheses. We aim to use prospective studies to evaluate treatment prognostic factors to derive clinically relevant questions and working hypotheses. These will be systematically tested through laboratory (microbial diseases, biomaterials and tissue engineering and physical [mechanical, electrical, fluid dynamics]) and human models. The work embraces microbiology, microbial-host interactions, tissue healing and imaging, impedance spectroscopy, fluid dynamics in viscously dominated environments and clinical trials.